Choroidal and retinal vascular changes in adults with Down syndrome: Insights into the Alzheimer's disease continuum DOI Creative Commons

Jamie Mitchell,

Adam Threlfall,

Kenneth R. Sloan

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(5)

Опубликована: Май 1, 2025

Abstract INTRODUCTION Retinal and choroidal vascular changes have been proposed as a non‐invasive central nervous system (CNS) proxy for clinical trials in Alzheimer's disease (AD). However, their role Down syndrome (DS), the largest genetically predisposed group AD, remains unclear. METHODS We conducted ultra‐widefield optical coherence tomography imaging on 24 individuals with DS 17 controls extracted various parameters. Data were analyzed using logistic linear regression models. RESULTS The retinae exhibited supernumerary vessels that wider thinned more rapidly along paths ( p = 0.01). There was complex retinal 0.047) less peripheral tree 0.001), increased numbers of microvascular abnormalities 0.038) reduced choroid vascularity index < 0.001). DISCUSSION found are present adults before onset AD might become early surrogates cerebral abnormalities. Highlights Eye showed seen AD. Far microaneurysms hemorrhages associated to DS. Wider faster thinning Reduced complexity retina linked Lower

Язык: Английский

Choroidal and retinal vascular changes in adults with Down syndrome: Insights into the Alzheimer's disease continuum DOI Creative Commons

Jamie Mitchell,

Adam Threlfall,

Kenneth R. Sloan

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(5)

Опубликована: Май 1, 2025

Abstract INTRODUCTION Retinal and choroidal vascular changes have been proposed as a non‐invasive central nervous system (CNS) proxy for clinical trials in Alzheimer's disease (AD). However, their role Down syndrome (DS), the largest genetically predisposed group AD, remains unclear. METHODS We conducted ultra‐widefield optical coherence tomography imaging on 24 individuals with DS 17 controls extracted various parameters. Data were analyzed using logistic linear regression models. RESULTS The retinae exhibited supernumerary vessels that wider thinned more rapidly along paths ( p = 0.01). There was complex retinal 0.047) less peripheral tree 0.001), increased numbers of microvascular abnormalities 0.038) reduced choroid vascularity index < 0.001). DISCUSSION found are present adults before onset AD might become early surrogates cerebral abnormalities. Highlights Eye showed seen AD. Far microaneurysms hemorrhages associated to DS. Wider faster thinning Reduced complexity retina linked Lower

Язык: Английский

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