Advances in Clinical Medicine, Год журнала: 2023, Номер 13(12), С. 18585 - 18591
Опубликована: Янв. 1, 2023
Язык: Английский
Neurology, Год журнала: 2024, Номер 102(11)
Опубликована: Май 18, 2024
Poststroke epilepsy (PSE) is associated with higher mortality and poor functional cognitive outcomes in patients stroke. With the remarkable development of acute stroke treatment, there a growing number survivors PSE. Although approximately 10% develop PSE, given significant burden worldwide, PSE problem survivors. Therefore, attention health policymakers funding are required to promote prevention research. The current definition includes unprovoked seizures occurring more than 7 days after onset, high recurrence risks seizures. However, pathologic cascade not uniform, indicating need for tissue-based approach rather time-based one distinguish early from late EEG commonly used tool diagnostic work-up findings during phase can potentially stratify risk subsequent predict poststroke epileptogenesis. Recent reports suggest that cortical superficial siderosis, which may be involved epileptogenesis, promising marker By incorporating such markers, future risk-scoring models could guide treatment strategies, particularly primary prophylaxis To date, drugs prevent epileptogenesis lacking. challenge involves substantial cost due difficulty reliably enrolling who There is, therefore, critical determine reliable biomarkers goal able use them trial enrichment as surrogate outcome measure Moreover, seizure essential decline Further elucidation factors contribute eagerly awaited. Meanwhile, regimen antiseizure medications should based on individual cardiovascular risk, psychosomatic comorbidities, concomitant medications. This review summarizes understanding its risks, prognostic models, prophylaxis, strategies secondary suggests advance research
Язык: Английский
Процитировано
20
Clinical Neurology and Neurosurgery, Год журнала: 2025, Номер unknown, С. 108846 - 108846
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Neurologia medico-chirurgica, Год журнала: 2024, Номер 64(3), С. 123 - 130
Опубликована: Янв. 30, 2024
Post-stroke epilepsy may occur after aneurysmal subarachnoid hemorrhage (aSAH). Both early and late seizures could cause severe neurocognitive deficits if administration of appropriate antiseizure medication is delayed. Therefore, it important to elucidate the risk factors for seizures, which be shared with medical teams promptly manage seizures. There are aspects both ischemia in aSAH, thus, numerous considered We examined associated aSAH-related Among 297 patients who had aSAH underwent direct or endovascular surgery, 25 20 Patients did not experience any at least 2-years follow-up (n = 81) were used as control group. Early older age acute nonneurological infection, whereas intraparenchymal lesion volume >10 mL shunt placement. In consistency was frequently observed between electroencephalogram presence lesions. The frontopolar electrode on highly sensitive abnormality induced by patient's systemic factors, lower threshold cortical excitability. lesions undergo placement should carefully followed up
Язык: Английский
Процитировано
3
Journal of Stroke, Год журнала: 2024, Номер 26(2), С. 179 - 189
Опубликована: Май 31, 2024
Background and Purpose Possible differences in the prevalence of cerebral amyloid angiopathy (CAA) East-Asian compared to Western populations have received little attention, results so far been ambiguous. Our aim is compare CAA neuropathology magnetic resonance imaging markers cohorts reflecting general population, cognitively normal elderly, patients with Alzheimer’s disease (AD), (lobar) intracerebral hemorrhage (ICH).Methods We performed a systematic literature search PubMed Embase for original research papers on published up until February 17th 2022. Records were screened by two independent reviewers. Pooled estimates determined using random-effects models. studies from Japan, China, Taiwan, South Korea (East-Asian cohorts) Europe or North America (Western meta-regression models.Results identified 12,257 unique records, we included 143 study 53 populations. Prevalence did not differ between any investigated patient domains. The strictly lobar microbleeds was lower population-based individuals (5.6% vs. 11.4%, P=0.020), elderly (2.6% P=0.001), ICH (10.2% 24.6%, P<0.0001). However, age cohorts.Conclusion AD, similar countries. In ICH, less prevalent, likely due their younger age. Consideration potential presence warranted decisions regarding antithrombotic treatment new anti-amyloid-β immunotherapy as AD countries alike.
Язык: Английский
Процитировано
3
Journal of NeuroInterventional Surgery, Год журнала: 2025, Номер unknown, С. jnis - 022686
Опубликована: Янв. 16, 2025
Post-stroke epilepsy (PSE) is a major complication of stroke. However, data about the predictors PSE in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy are limited. To evaluate relationship between intraoperative angiographic signs and risk anterior circulation AIS who underwent thrombectomy. We conducted retrospective study. A total 800 were classified into case control groups based on occurrence PSE. Propensity score matching (PSM) (1:4) was applied using covariates such as age, sex, National Institutes Health Stroke Scale at admission, baseline modified Rankin score. Conditional logistic regression mediation analysis performed. Subgroup analyses to assess effect modification. diagnostic model clinical characteristics developed. After PSM, 67 234 without PSE, respectively, selected. The group had significantly higher incidences hemorrhagic transformation, early seizures, venous filling (EVF) sign, inferior frontal gyrus (IFG), hippocampus, basal ganglia blush larger infarct size. adjusting for hypertension, diabetes, size, seizure, IFG, hippocampus involvement, EVF remained independently associated Hemorrhagic transformation mediated 14.87% EVF-PSE associations. Comparison evaluation metrics each showed that 3 exhibited best overall performance. mediates association. key following
Язык: Английский
Процитировано
0
JAMA Neurology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
Importance Poststroke epilepsy (PSE) is a major complication among young adults and associated with problems functional recovery daily life. Although scores have been developed to predict risk of PSE, they not validated patients stroke at age. Objectives To investigate both the factors for PSE age validate current cohort adults. Design, Setting, Participants This study used data from ODYSSEY (Observational Dutch Young Symptomatic Stroke Study), prospective conducted 17 hospitals in Netherlands between May 27, 2013, March 3, 2021, follow-up until February 28, 2024. included 1388 consecutive aged 18 49 years neuroimaging-proven ischemic or intracerebral hemorrhage (ICH) without history epilepsy. Statistical analysis took place June August Exposure First-ever ICH. Main Outcomes Measures was defined as least 1 remote symptomatic seizure (&gt;7 days). Cumulative incidence functions were calculate 5-year PSE. Fine-Gray regression models identify (age, sex, clinical stroke, neuroimaging variables). The performances SeLECT (severity large-artery atherosclerosis, early seizure, cortical involvement, territory middle cerebral artery) 2.0 score (for stroke) CAVE (cortical age, bleeding volume, seizure) ICH) assessed C statistics calibration bar plots. Results (ischemic 1231 [88.7%]; ICH, 157 [11.3%]; median 44.1 [IQR, 38.0-47.4 years]; 736 men [53.0%]; follow-up, 5.3 3.4-7.4 years]), whom 57 (4.1%) cumulative 3.7% (95% CI, 0.2%-4.8%) after 7.6% 3.5%-11.8%) Factors an acute (&lt;7 days) (hazard ratio [HR], 10.83 [95% 2.05-57.07]; P = .005) involvement (HR, 5.35 1.85-15.49]; .002). only factor ICH 8.20 2.22-30.25]; statistic 0.78 0.71-0.84) 0.83 0.76-0.90) score, good scores. Conclusion suggests that relatively low similar variables existing scores, which can therefore also be applied stroke. Future trials should optimal primary secondary prophylaxis high risk.
Язык: Английский
Процитировано
0
Epilepsy Research, Год журнала: 2023, Номер 199, С. 107282 - 107282
Опубликована: Дек. 14, 2023
Язык: Английский
Процитировано
8
Neurology Clinical Practice, Год журнала: 2023, Номер 13(2)
Опубликована: Март 14, 2023
In an era of time-dependent reperfusion and recanalization therapy for stroke leading to improved survival, there is a growing population at risk poststroke epilepsy (PSE). Accumulating evidence suggests multidirectional interaction among stroke, PSE, dementia in survivors. There no justify prophylactic antiseizure medication (ASM) reduce these morbidities. Although several predictive molecular biomarkers scoring models have been proposed, they remain inadequately validated stratifying indicating who will benefit from ASM. Studies leveraging advances genetics, metabolomics, electrophysiology, imaging, artificial intelligence (AI) may help discover noninvasive easy-to-score models. These discoveries should improve our understanding epileptogenesis PSE identify new pharmacologic targets. Besides, accurately identifying high-risk patients timely initiating ASM has the potential disrupt feed-forward dementia.
Язык: Английский
Процитировано
4
Frontiers in Neurology, Год журнала: 2024, Номер 14
Опубликована: Янв. 8, 2024
Background Cerebral amyloid angiopathy (CAA), a cerebral small vessel disease affecting leptomeningeal and cortical blood vessels, is common cause of spontaneous lobar intracerebral hemorrhage cognitive impairment, particularly in elderly patients. This study aims to investigate the field CAA research from scientometric perspective. Methods Publications related January 1st, 1999 September 29th, 2023 were retrieved Web Science Core Collection database. The software VOSviewer CiteSpace used analyze visualize publication trends, countries/regions, institutions, authors, journals, cited references, keywords CAA. Results A total 2,798 publications 73 led by United States, included. number showed an increasing trend over time. Massachusetts General Hospital was most productive institution, authors Greenberg Charidimou published papers frequently co-cited. Journal Alzheimer's Disease prolific journal this field, Neurology co-cited journal. Apart “cerebral angiopathy”, “Alzheimer's disease”, “amyloid beta”, “intracerebral hemorrhage”, “dementia”. burst recent years included “cortical superficial siderosis” “dysfunction”. Conclusions analysis provides comprehensive overview past 25 years, offers important insights for future directions scientific decision-making field.
Язык: Английский
Процитировано
1
Epilepsy & Behavior, Год журнала: 2024, Номер 155, С. 109752 - 109752
Опубликована: Апрель 18, 2024
Язык: Английский
Процитировано
1