Dietary and lifestyle interventions for the management of hereditary ataxias DOI Creative Commons

Wenyao Yang,

Bruce Thompson,

Faith Kwa

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 24, 2025

Hereditary ataxia (HA) is a diverse group of rare inherited neurological disorders characterised by cerebellar impairment and the progressive degeneration spinocerebellar tracts spinal cord. These conditions manifest predominantly as unsteady gait, speech difficulties, dysphagia motor skill impairment. The complex genetic causes varied disease mechanisms underlying HA contribute to multi-systemic symptoms which pose challenges in developing targeted effective treatments. Currently, available options for primarily focus on symptomatic management, highlighting critical need complementary therapeutic strategies, such dietary lifestyle interventions. This review explains recent findings nutraceutical interventions, well modifications exercise rehabilitation programs HA. It outlines common types HA, including Friedreich ataxia, ataxias, with vitamin E deficiency, ataxia-telangiectasia, studies mixed cohort patients current management options, implications from pre-clinical clinical data future directions advance treatment will also be discussed. integration nutraceuticals methods encouraged holistic interventions complement use various technological aids support multidisciplinary health medical team improve monitoring status progression affected individuals; thus facilitating early an optimised outcome.

Язык: Английский

Dietary and lifestyle interventions for the management of hereditary ataxias DOI Creative Commons

Wenyao Yang,

Bruce Thompson,

Faith Kwa

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 24, 2025

Hereditary ataxia (HA) is a diverse group of rare inherited neurological disorders characterised by cerebellar impairment and the progressive degeneration spinocerebellar tracts spinal cord. These conditions manifest predominantly as unsteady gait, speech difficulties, dysphagia motor skill impairment. The complex genetic causes varied disease mechanisms underlying HA contribute to multi-systemic symptoms which pose challenges in developing targeted effective treatments. Currently, available options for primarily focus on symptomatic management, highlighting critical need complementary therapeutic strategies, such dietary lifestyle interventions. This review explains recent findings nutraceutical interventions, well modifications exercise rehabilitation programs HA. It outlines common types HA, including Friedreich ataxia, ataxias, with vitamin E deficiency, ataxia-telangiectasia, studies mixed cohort patients current management options, implications from pre-clinical clinical data future directions advance treatment will also be discussed. integration nutraceuticals methods encouraged holistic interventions complement use various technological aids support multidisciplinary health medical team improve monitoring status progression affected individuals; thus facilitating early an optimised outcome.

Язык: Английский

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