Breaking the Electric-Dipole Selection Rule via a Plasmonic Nanocavity Excited by a k-Space Filter-Assisted Radial Vector Beam DOI

Yueweiying Wang,

Chao Meng,

Chenyang Kong

и другие.

ACS Photonics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1 DOI Creative Commons

James F. Conley,

Lauren E. Brown, James McNeely

и другие.

ACS Omega, Год журнала: 2025, Номер 10(6), С. 5795 - 5808

Опубликована: Фев. 10, 2025

Eukaryotic initiation factor 4A-1 (eIF4A1) is an ATP-dependent RNA helicase that unwinds 5'-UTR mRNA secondary structures to facilitate cap-dependent translation initiation. Rocaglates, a class of natural products typified by rocaglamide A (RocA), possess antineoplastic and anti-infectious activity mediated their interaction with eIF4A1. Rocaglates inhibit "clamping" eIF4A1 onto polypurine RNA, which impedes ribosome scanning. novel rocaglate derivatives, amidino-rocaglates (ADRs) feature amidine ring fused the core, particularly effective at promoting eIF4A1-RNA-clamping compared other congeners. Herein, we present X-ray crystal structure ADR in complex eIF4A1, nonhydrolyzable ATP ground-state mimic adenylyl-imidodiphosphate (AMPPNP), poly r(AG)5 refined 1.69 Å resolution. The binding pose interactions do not differ substantially from those RocA, prompting investigation basis for enhanced target engagement. Computational modeling suggests rigidified scaffold inherently preorganized eIF4A1-RNA binding-competent conformation, thereby avoiding entropic penalties associated RocA binding. This study illustrates how conformational rigidification can be leveraged improve potency development rocaglates as potential anticancer agents.

Язык: Английский

Процитировано

0
In-silico color prediction process for natural dyes in Madder DOI
Thanh Huyen Linh Tran, Romain Berraud‐Pache, Maguy Jaber

и другие.

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112701 - 112701

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Primary radical ions in irradiated carbonates DOI
Irina S. Tretyakova, V. I. Borovkov

Physical Chemistry Chemical Physics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The decomposition of primary radical cations in irradiated carbonates via proton transfer is thermodynamically favorable but kinetically hindered.

Язык: Английский

Процитировано

0
Diverse synthetic approaches to 3-arylmethylidene- and bis-3,5-arylmethylidene-N-benzylpiperidin-4-ones with thiophene scaffolds: The comparative experimental study DOI
Zita Tokárová,

Natália Kabaňová,

Júlia Korcová

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142133 - 142133

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Breaking the Electric-Dipole Selection Rule via a Plasmonic Nanocavity Excited by a k-Space Filter-Assisted Radial Vector Beam DOI

Yueweiying Wang,

Chao Meng,

Chenyang Kong

и другие.

ACS Photonics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

0