Efficient Synthesis of Diaryl Quaternary Centers by Rh(II)/Xantphos Catalyzed Relay C−H Functionalization and Allylic Alkylation DOI

Zhaoliang Ge,

Bin Lu, Huai‐Long Teng

и другие.

Chemistry - A European Journal, Год журнала: 2022, Номер 29(3)

Опубликована: Окт. 14, 2022

A three-component reaction of N, N-disubstituted aniline, α-diazo ester, and an allylic electrophile has been realized by [Rh(II)]2 /Xantphos catalysis, providing a direct access to various aniline derivatives bearing diaryl quaternary centers in good yields. The synthetic utility this protocol was demonstrated facile derivatization the products for preparation biologically relevant molecules structural scaffolds, which offers high potential increasing molecular diversity. Mechanistic studies identified α, α-diarylacetate species as active intermediate, thereby revealing presence C(sp2 )-H functionalization derivatives/allylic alkylation cascade attractive catalytic transformation.

Язык: Английский

Efficient Synthesis of Diaryl Quaternary Centers by Rh(II)/Xantphos Catalyzed Relay C−H Functionalization and Allylic Alkylation DOI

Zhaoliang Ge,

Bin Lu, Huai‐Long Teng

и другие.

Chemistry - A European Journal, Год журнала: 2022, Номер 29(3)

Опубликована: Окт. 14, 2022

A three-component reaction of N, N-disubstituted aniline, α-diazo ester, and an allylic electrophile has been realized by [Rh(II)]2 /Xantphos catalysis, providing a direct access to various aniline derivatives bearing diaryl quaternary centers in good yields. The synthetic utility this protocol was demonstrated facile derivatization the products for preparation biologically relevant molecules structural scaffolds, which offers high potential increasing molecular diversity. Mechanistic studies identified α, α-diarylacetate species as active intermediate, thereby revealing presence C(sp2 )-H functionalization derivatives/allylic alkylation cascade attractive catalytic transformation.

Язык: Английский

Процитировано

20