Highly Enantioselective Construction of Multifunctional Silicon‐Stereogenic Silacycles by Asymmetric Enamine Catalysis
Xue‐Xin Zhang,
Yang Gao,
Yan‐Xue Zhang
и другие.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(9)
Опубликована: Янв. 10, 2023
We
report
the
first
highly
enantioselective
construction
of
silicon-stereocenters
by
asymmetric
enamine
catalysis.
An
unprecedented
desymmetric
intramolecular
aldolization
prochiral
siladials
was
thus
developed
for
facile
access
multifunctional
silicon-stereogenic
silacycles
in
high
to
excellent
enantioselectivity.
With
an
enal
moiety,
these
adducts
could
be
readily
elaborated
diverse
synthesis
compounds,
and
late-stage
modification.
Язык: Английский
Recent Progress in the Synthesis of Silaspiranes
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(70)
Опубликована: Сен. 23, 2023
Abstract
Silaspiranes
bearing
a
spiro‐silicon
center
are
promising
ring
frameworks
for
the
synthesis
of
novel
spirocyclic
molecules
possessing
unique
properties.
Development
efficient
methods
towards
these
structures
has
therefore
attracted
considerable
attentions
synthetic
chemists.
This
minireview
highlights
representative
advances
in
field,
and
is
categorized
into
four
parts
according
to
formation
strategies:
cyclization,
annulation,
expansion
cycloaddition.
Язык: Английский
Rhodium-Catalyzed (Asymmetric) Annulation of Silacyclobutanes with Bicyclic Olefins via C–Si Bond Activation
ACS Catalysis,
Год журнала:
2024,
Номер
unknown, С. 17453 - 17459
Опубликована: Ноя. 12, 2024
The
carbon-to-silicon
switch
gives
rise
to
silacycles
that
offer
eminent
biological
and
photophysical
properties.
Access
chiral
silacycles,
especially
midsized
ones,
via
intermolecular
coupling
remains
a
considerable
challenge
due
limited
synthetic
methods.
Herein,
rhodium(I)-catalyzed
annulations
between
benzosilacyclobutenes
(SCBs)
bicyclic
olefins
are
presented.
A
series
of
stable
seven-membered
have
been
accessed
in
high
enantioselectivity
the
enantioselective
[4
+
3]
annulation
SCBs
7-oxabenzonorbornadienes
formal
[2σ
2σ]
C–C
O–Si
coupling.
mechanism
has
investigated,
where
C–Si
oxidative
addition
SCB
established
as
turnover-limiting
step.
Язык: Английский
Highly Enantioselective Construction of Multifunctional Silicon‐Stereogenic Silacycles by Asymmetric Enamine Catalysis
Xue‐Xin Zhang,
Yang Gao,
Yan‐Xue Zhang
и другие.
Angewandte Chemie,
Год журнала:
2023,
Номер
135(9)
Опубликована: Янв. 10, 2023
Abstract
We
report
the
first
highly
enantioselective
construction
of
silicon‐stereocenters
by
asymmetric
enamine
catalysis.
An
unprecedented
desymmetric
intramolecular
aldolization
prochiral
siladials
was
thus
developed
for
facile
access
multifunctional
silicon‐stereogenic
silacycles
in
high
to
excellent
enantioselectivity.
With
an
enal
moiety,
these
adducts
could
be
readily
elaborated
diverse
synthesis
compounds,
and
late‐stage
modification.
Язык: Английский