Chiral Phosphoric Acid‐Catalyzed Enantioselective Synthesis of Axially Chiral Compounds Involving Indole Derivatives DOI
Jun Kee Cheng, Bin Tan

The Chemical Record, Год журнала: 2023, Номер 23(11)

Опубликована: Июнь 26, 2023

Indoles are one of the most ubiquitous subclass N-heterocycles and increasingly incorporated to design new axially chiral scaffolds. The rich profile reactivity N-H functionality allow chemical derivatization for enhanced medicinal, material catalytic properties. Although asymmetric C-C coupling two arenes gives direct access biaryl scaffolds, this chemistry has been remit metal catalysis works efficiently on limited substrates. Our group devoted special interest in devising novel organocatalytic arylation reactions fabricate atropisomers. In realm, indoles derivatives have reliably used as partners combination with azoarenes, nitrosonapthalenes quinone derivatives. Their efficient interaction phosphoric acid catalyst well tunability electronics sterics enabled excellent control stereo-, chemo- regioselectivity furnish diverse addition, could act nucleophiles desymmetrization 1,2,4-triazole-3,5-diones. This account provides a succinct illustration these developments.

Язык: Английский

Chiral Phosphoric Acid‐Catalyzed Enantioselective Synthesis of Axially Chiral Compounds Involving Indole Derivatives DOI
Jun Kee Cheng, Bin Tan

The Chemical Record, Год журнала: 2023, Номер 23(11)

Опубликована: Июнь 26, 2023

Indoles are one of the most ubiquitous subclass N-heterocycles and increasingly incorporated to design new axially chiral scaffolds. The rich profile reactivity N-H functionality allow chemical derivatization for enhanced medicinal, material catalytic properties. Although asymmetric C-C coupling two arenes gives direct access biaryl scaffolds, this chemistry has been remit metal catalysis works efficiently on limited substrates. Our group devoted special interest in devising novel organocatalytic arylation reactions fabricate atropisomers. In realm, indoles derivatives have reliably used as partners combination with azoarenes, nitrosonapthalenes quinone derivatives. Their efficient interaction phosphoric acid catalyst well tunability electronics sterics enabled excellent control stereo-, chemo- regioselectivity furnish diverse addition, could act nucleophiles desymmetrization 1,2,4-triazole-3,5-diones. This account provides a succinct illustration these developments.

Язык: Английский

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