New Synthetic Approaches for the Construction of Enantioenriched Molecules Bearing Quaternary Stereocenters DOI
Zhou Sun, Jiaxuan Liu, Lin Shi

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(21), С. 4294 - 4322

Опубликована: Авг. 17, 2024

Abstract Optically active molecule architectures stand as an important class of organic compounds and occupy a key role in academic industrial communities. Particularly, the molecules bearing quaternary carbon are vital importance because its favorable conformation valuable three‐dimensional molecules, which frequently play broad spectrum functional materials, pharmaceutical relevant natural agrochemicals. Over past few decades, large number synthetic strategies for enantioselective construction with chiral centers have been focus research initiatives. In this review, state‐of‐the‐art toward synthesis enantioenriched stereocenters summarized, could be segmented into four categories: 1) Construction optically by addition to prochiral sp 2 carbon; 2) all‐carbon via substitution at non‐chiral tetra‐substituted 3) kinetic resolution; 4) desymmetrization reactions.

Язык: Английский

New Synthetic Approaches for the Construction of Enantioenriched Molecules Bearing Quaternary Stereocenters DOI
Zhou Sun, Jiaxuan Liu, Lin Shi

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(21), С. 4294 - 4322

Опубликована: Авг. 17, 2024

Abstract Optically active molecule architectures stand as an important class of organic compounds and occupy a key role in academic industrial communities. Particularly, the molecules bearing quaternary carbon are vital importance because its favorable conformation valuable three‐dimensional molecules, which frequently play broad spectrum functional materials, pharmaceutical relevant natural agrochemicals. Over past few decades, large number synthetic strategies for enantioselective construction with chiral centers have been focus research initiatives. In this review, state‐of‐the‐art toward synthesis enantioenriched stereocenters summarized, could be segmented into four categories: 1) Construction optically by addition to prochiral sp 2 carbon; 2) all‐carbon via substitution at non‐chiral tetra‐substituted 3) kinetic resolution; 4) desymmetrization reactions.

Язык: Английский

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