Recent Advance in Electrochemical Dehalogenative Deuteration
Deleted Journal,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 24, 2024
In
recent
years,
the
incorporation
of
deuterium
atoms
into
organic
compounds
has
emerged
as
a
vital
focus
in
development
pharmaceutical
molecules.
This
trend
is
driven
by
increasing
recognition
significance
containing
across
various
domains,
including
materials
and
biopharmaceuticals,
where
they
have
found
widespread
applications
mechanistic
studies
within
realms
chemistry
biology.
Meanwhile,
electrochemistry,
relatively
environmentally
friendly
catalytic
mode
with
broad
adaptability
to
redox
reactions,
crucial
alternative
traditional
halogen-deuterium
exchange
context
reduction
deuteration
halides.
approach
circumvents
uses
transition
metal
catalysts
toxic
deuterated
reagents
which
are
commonly
employed
methods.
Notably,
electrocatalytic
dehalogenation
typically
relies
on
heavy
water
source,
ensuring
high
yields
significant
incorporation.
electrochemically
dehalogenative
halides
made
substantial
progress,
providing
critical
support
for
synthesis
compounds.
article
offers
comprehensive
overview
latest
advancements
electrochemical
reductive
both
aromatic
alkyl
halides,
categorizing
progress
according
type
halide
delving
underlying
reaction
mechanisms.
Язык: Английский
Probing Diazo Compounds for Electro-Cascade Thiolation/Cyclization/Reduction Sequence
Опубликована: Авг. 28, 2024
Diazo
compounds
have
extensively
been
investigated
under
light
or
metal-mediated
conditions
to
carry
out
carbene-mediated
transformations.
In
the
search
for
novel
reactivity,
investigating
these
dinitrogen
substrates
electrochemical
remained
underexplored.
Herein,
we
explored
diazo
establish
a
cascade
sequence
of
thiolation/cyclization/reduction
reactions.
Electrolyzing
styryl
imides
and
aryl
thiols
enables
direct
access
single
diastereoisomer
2,5-pyrrolidine-dione-fused
thiochromans
in
good
yields
mild
metal-free
conditions.
Notably,
tunable
reactivity
was
achieved
via
S-H
insertion
at
center
slightly
modified
reaction
Based
on
experimental
evidences,
including
detection
key
intermediates
computational
studies,
mechanism
has
also
established.
Язык: Английский
Correspondence on “Organo‐Mediator Enabled Electrochemical Deuteration of Styrenes”
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(46)
Опубликована: Май 2, 2024
The
recently
reported
electrochemical,
organo-mediator
enabled
deuteration
of
styrenes,
a
reaction
referred
to
as
"electrochemical
deuterium
atom
transfer",
differs
mechanistically
from
direct
electrochemical
hydrogenations/deuterations
only
by
mediated,
homogeneous
SET
the
substrates.
By
comparing
vs.
mediated
processes
in
general
and
for
styrene
reduction,
we
display
that
Qiu's
work
does
not
change
concept
this
chemistry.
Experiments
with
mediators
reduction
examples
scope
show
even
electron-rich
substrates
can
be
reduced
when
our
protocol,
published
six
months
before
work,
is
applied.
Язык: Английский
Electrocatalytic Multicomponent Cascade Cross-Coupling for Synthesis of Chalcogenosulfonates
Authorea (Authorea),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 16, 2024
An
method
for
the
electrochemical
synthesis
of
chalcogenosulfonates
via
a
tandem
multi-component
reaction
has
been
developed.
This
is
performed
in
an
undivided
cell
without
requirement
external
oxidants,
acids,
and
transition
metals.
A
variety
indoles
sulfinic
acid
sodium
salts
can
be
used
this
method,
it
effective
late-stage
modifications
complex
molecules.
Not
only
thiosulfonates
selenosulfonates
but
also
sulfonotelluroates
could
prepared,
making
protocol
useful
tool
devel-opment
new
functional
The
afforded
products
are
promising
pesticide
development.
Язык: Английский
Correspondence on “Organo‐Mediator Enabled Electrochemical Deuteration of Styrenes”
Angewandte Chemie,
Год журнала:
2024,
Номер
136(46)
Опубликована: Май 2, 2024
Abstract
The
recently
reported
electrochemical,
organo‐mediator
enabled
deuteration
of
styrenes,
a
reaction
referred
to
as
“electrochemical
deuterium
atom
transfer”,
differs
mechanistically
from
direct
electrochemical
hydrogenations/deuterations
only
by
mediated,
homogeneous
SET
the
substrates.
By
comparing
vs.
mediated
processes
in
general
and
for
styrene
reduction,
we
display
that
Qiu's
work
does
not
change
concept
this
chemistry.
Experiments
with
mediators
reduction
examples
scope
show
even
electron‐rich
substrates
can
be
reduced
when
our
protocol,
published
six
months
before
work,
is
applied.
Язык: Английский