Modulating the Aggregation States of a Pd6L4 Cage for Selectivity Flipping during the Stereo‐Divergent Semi‐Hydrogenation of Alkynes DOI Open Access
Wei Zhong, Jing Xu, Song Zhao

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract An enzyme‐mimicking catalytic system has been established using a singular palladium‐based octahedral cage as the supramolecular reactor, deftly unlocking off‐on‐off selectivity in semi‐hydrogenation of alkynes. Water serves critical regulator, modulating catalyst states, reaction rates, and endpoints. The choice solvent influences activity host–guest binding types homogeneous heterogeneous catalysis, effectively modifying steps involved Z → E isomerization during Kinetic inhibition experiments indicate that mimics activation characteristics enzymes towards substrates, enabling selective transformations within confined environment. utility this switchable cage‐confined catalysis demonstrated synthesis modification complex biologically active molecules with controllable / selectivity. This work sheds light on design control artificial counterparts enzymes, offering fundamental insights into factors influencing biological macromolecules.

Язык: Английский

Modulating the Aggregation States of a Pd6L4 Cage for Selectivity Flipping during the Stereo‐Divergent Semi‐Hydrogenation of Alkynes DOI
Wei Zhong,

Xu Jing,

Zhao Song

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract An enzyme‐mimicking catalytic system has been established using a singular palladium‐based octahedral cage as the supramolecular reactor, deftly unlocking off‐on‐off selectivity in semi‐hydrogenation of alkynes. Water serves critical regulator, modulating catalyst states, reaction rates, and endpoints. The choice solvent influences activity host–guest binding types homogeneous heterogeneous catalysis, effectively modifying steps involved Z → E isomerization during Kinetic inhibition experiments indicate that mimics activation characteristics enzymes towards substrates, enabling selective transformations within confined environment. utility this switchable cage‐confined catalysis demonstrated synthesis modification complex biologically active molecules with controllable / selectivity. This work sheds light on design control artificial counterparts enzymes, offering fundamental insights into factors influencing biological macromolecules.

Язык: Английский

Процитировано

1
Modulating the Aggregation States of a Pd6L4 Cage for Selectivity Flipping during the Stereo‐Divergent Semi‐Hydrogenation of Alkynes DOI Open Access
Wei Zhong, Jing Xu, Song Zhao

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract An enzyme‐mimicking catalytic system has been established using a singular palladium‐based octahedral cage as the supramolecular reactor, deftly unlocking off‐on‐off selectivity in semi‐hydrogenation of alkynes. Water serves critical regulator, modulating catalyst states, reaction rates, and endpoints. The choice solvent influences activity host–guest binding types homogeneous heterogeneous catalysis, effectively modifying steps involved Z → E isomerization during Kinetic inhibition experiments indicate that mimics activation characteristics enzymes towards substrates, enabling selective transformations within confined environment. utility this switchable cage‐confined catalysis demonstrated synthesis modification complex biologically active molecules with controllable / selectivity. This work sheds light on design control artificial counterparts enzymes, offering fundamental insights into factors influencing biological macromolecules.

Язык: Английский

Процитировано

0