Photocatalyzed 1,3-Bromodifluoroallylation of [1.1.1]Propellane with α-Trifluoromethylalkenes and KBr Salts

Organic Letters, Год журнала: 2024, Номер 26(32), С. 6889 - 6893

Опубликована: Авг. 6, 2024

Herein we unveil a visible-light-driven transition-metal-free 1,3-bromodifluoroallylation of [1.1.1]propellane. This reactivity is harnessed through organophotocatalysis, providing practical synthetic pathways to 1-brominated-3-

Язык: Английский

Photocatalytic Diheteroarylation of [1.1.1]Propellane for the Construction of 1,3-Diheteroaryl Bicyclo[1.1.1]pentanes

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Herein, we report a visible light-induced diheteroarylation reaction of [1.1.1]propellane to synthesize 1,3-diheteroaryl bicyclo[1.1.1]pentanes (BCPs). In this approach, heteroaryl radicals are generated from halides via photocatalysis and subsequently added [1.1.1]propellane. The

Язык: Английский

Electron Donor–Acceptor Complex-Driven Divergent Routes to α-Amino Bicyclopentyl Iodides and Methylene Cyclobutanols

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 24, 2024

Amines are essential due to their structural diversity and biological significance. Introducing the valuable bicyclopentane (BCP) moiety at α-position of amines offers a promising strategy for developing novel bioactive compounds. This study outlines divergent synthesis approach generate α-amino-functionalized bicyclopentyl iodides methylene cyclobutanols under mild environmentally sustainable conditions. By employing an electron donor-acceptor (EDA) complex between amine inexpensive readily available inorganic base Cs

Язык: Английский