Recent advances using [Cp*Co(CO)I₂] catalysts as a powerful tool for C–H functionalisation

Dalton Transactions, Год журнала: 2017, Номер 46(30), С. 9721 - 9739

Опубликована: Янв. 1, 2017

This perspective highlights recent applications of Cp*Co^III catalysts in C–H functionalisation protocols, exemplifying both terminal couplings and heterocycle formation.

Язык: Английский

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C–H Alkylations of (Hetero)Arenes by Maleimides and Maleate Esters through Cobalt(III) Catalysis

Organic Letters, Год журнала: 2017, Номер 19(12), С. 3315 - 3318

Опубликована: Июнь 7, 2017

Efficient cobalt(III)-catalyzed (hetero)aryl and alkenyl C–H hydroarylations of maleimides maleate esters have been achieved under remarkably mild reaction conditions. Thus, the versatile cobalt(III) catalyst [Cp*CoI2(CO)] showed excellent atom−and step−economy as well high chemo- site-selectivity providing expedient access to pharmacologically useful succinimides with wide functional group tolerance.

Язык: Английский

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Cp*Rh(III)/Bicyclic Olefin Cocatalyzed C–H Bond Amidation by Intramolecular Amide Transfer

Journal of the American Chemical Society, Год журнала: 2017, Номер 139(18), С. 6506 - 6512

Опубликована: Апрель 18, 2017

A bicyclic olefin was discovered as a cocatalyst in Cp*Rh(III)-catalyzed C–H bond amidation proceeding by an intramolecular amide transfer N-phenoxyacetamide derivatives. Combining experimental and theoretical studies, we propose that the promotes Rh(III) intermediate to undergo oxidative addition into O–N form Rh(V) nitrenoid species subsequently direct add ortho position. The directing group plays dual role cleavable coordinating moiety well essential coupling partner for amidation. This methodology successfully applied late-stage diversification of natural products marketed drug under mild conditions.

Язык: Английский

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Cobalt-Catalyzed Oxidant-Free Spirocycle Synthesis by Liberation of Hydrogen

Organic Letters, Год журнала: 2017, Номер 19(17), С. 4640 - 4643

Опубликована: Авг. 21, 2017

The first example of oxidant-free cobalt-catalyzed synthesis five-membered spirocycles is reported from benzimidates and maleimides utilizing nitrobenzene as promoter. In contrast to previously known oxidative C–H functionalization reactions, this transformation occurs efficiently in the absence oxidant accompanied by liberation hydrogen. spiro-lactams were readily achieved hydrolysis as-prepared spirocyclic compounds. Cp*Rh(III) catalyst shows poor reactivity.

Язык: Английский

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Cobalt(III)‐Catalyzed Enantioselective Intermolecular Carboamination by C−H Functionalization

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(2), С. 655 - 659

Опубликована: Сен. 28, 2020

Abstract High‐valent cyclopentadienyl cobalt catalysis is a versatile tool for sustainable C−H bond functionalizations. To harness the full potential of this strategy, control stereoselectivity these processes necessary. Herein, we report highly enantioselective intermolecular carboaminations alkenes through activation N ‐phenoxyamides catalyzed by Co III ‐complexes equipped with chiral (Cp x ) ligands. The method converts widely available acrylates as well bicyclic olefins into attractive enantioenriched isotyrosine derivatives elaborated amino‐substituted scaffolds under very mild conditions. outlined reactivity unique to Cp complexes and complementary 4d‐ 5d‐ precious‐metal catalysts.

Язык: Английский

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