Advanced Synthesis & Catalysis,
Год журнала:
2018,
Номер
360(13), С. 2470 - 2475
Опубликована: Апрель 27, 2018
Abstract
An
efficient,
mild
and
redox‐neutral
iridium(III)‐catalyzed
C−H
annulation
of
N
‐phenoxyacetamides
for
the
regioselective
synthesis
benzofurans
has
been
developed
by
employing
tertiary
propargyl
alcohols
as
versatile
coupling
partners.
The
computed
results
together
with
experimental
data
revealed
that
hydroxyl
group
acts
key
factor
in
controlling
regioselectivity
tuning
reactivity.
magnified
image
Chemical Reviews,
Год журнала:
2018,
Номер
119(4), С. 2192 - 2452
Опубликована: Ноя. 27, 2018
C–H
activation
has
surfaced
as
an
increasingly
powerful
tool
for
molecular
sciences,
with
notable
applications
to
material
crop
protection,
drug
discovery,
and
pharmaceutical
industries,
among
others.
Despite
major
advances,
the
vast
majority
of
these
functionalizations
required
precious
4d
or
5d
transition
metal
catalysts.
Given
cost-effective
sustainable
nature
earth-abundant
first
row
metals,
development
less
toxic,
inexpensive
3d
catalysts
gained
considerable
recent
momentum
a
significantly
more
environmentally-benign
economically-attractive
alternative.
Herein,
we
provide
comprehensive
overview
on
until
summer
2018.
Chemical Society Reviews,
Год журнала:
2018,
Номер
47(17), С. 6603 - 6743
Опубликована: Янв. 1, 2018
The
present
review
is
devoted
to
summarizing
the
recent
advances
(2015-2017)
in
field
of
metal-catalysed
group-directed
C-H
functionalisation.
In
order
clearly
showcase
molecular
diversity
that
can
now
be
accessed
by
means
directed
functionalisation,
whole
organized
following
directing
groups
installed
on
a
substrate.
Its
aim
comprehensive
reference
work,
where
specific
group
easily
found,
together
with
transformations
which
have
been
carried
out
it.
Hence,
primary
format
this
schemes
accompanied
concise
explanatory
text,
are
ordered
sections
according
their
chemical
structure.
feature
typical
substrates
used,
products
obtained
as
well
required
reaction
conditions.
Importantly,
each
example
commented
respect
most
important
positive
features
and
drawbacks,
aspects
such
selectivity,
substrate
scope,
conditions,
removal,
greenness.
targeted
readership
both
experts
functionalisation
chemistry
(to
provide
overview
progress
made
last
years)
and,
even
more
so,
all
organic
chemists
who
want
introduce
way
thinking
for
design
straightforward,
efficient
step-economic
synthetic
routes
towards
molecules
interest
them.
Accordingly,
should
particular
also
scientists
from
industrial
R&D
sector.
overall
goal
promote
application
reactions
outside
research
dedicated
method
development
establishing
it
valuable
archetype
contemporary
R&D,
comparable
role
cross-coupling
play
date.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
57(47), С. 15425 - 15429
Опубликована: Окт. 6, 2018
The
enantioselective
cobalt(III)-catalyzed
C-H
alkylation
was
achieved
through
the
design
of
a
novel
chiral
acid.
activation
characterized
by
high
position-,
regio-
and
enantio-control
under
exceedingly
mild
reaction
conditions.
Thereby,
robust
cooperative
cobalt(III)
catalysis
proved
tolerant
valuable
electrophilic
functional
groups,
including
hydroxyl,
bromo,
iodo
substituents.
Mechanistic
studies
revealed
considerable
additive
effect
on
kinetics
negative
non-linear-effect.
ACS Catalysis,
Год журнала:
2022,
Номер
12(6), С. 3452 - 3506
Опубликована: Март 3, 2022
Transition-metal-catalyzed
C–H
bond
functionalizations
have
had
an
enormous
influence
on
organic
synthesis
in
recent
times.
However,
the
use
of
low-abundance
4d
and
5d
metals
is
almost
inevitable,
they
are
high
demand.
This
will
be
a
cause
concern,
hence,
it
important
to
develop
methods
based
3d
metals,
which
widely
present
Earth's
crust.
In
this
regard,
metal
catalysts
or
their
precursors
for
catalysis,
general,
functionalizations,
particular,
has
gained
significant
momentum
The
major
development
catalytic
with
been
achieved
predominantly
strongly
coordinating
directing
groups
such
as
pyridyl,
pyrimidinyl,
pyrazolyl,
8-amino-quinolinyl
groups.
Thus,
prefunctionalization
substrates
these
necessary,
contradicts
step-
atom-economy
activation.
commonly
available
functional
aldehyde,
ketone,
carboxylic
acid,
amide,
hydroxy,
N-oxides
loosely
bind
through
weak-coordination.
These
weakly
orient
activate
regioselectively
without
need
preinstalled
Although
challenging,
contemporary
topic
actively
pursued
by
many
researchers
Through
article,
we
provide
comprehensive
overview
metal-catalyzed,
coordinating,
directing-group-enabled
reported
until
March
2021.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(6), С. 3677 - 3689
Опубликована: Янв. 1, 2021
In
this
tutorial
review,
the
rapid
advances
of
directing
group
(DG)
migration
in
transition-metal-catalysed
direct
C–H
activation
was
presented
through
analyzing
and
comparing
different
bond
cleavage
trigger
DG
(including
N–O,
N–C,
N–N
or
O–C).
Dalton Transactions,
Год журнала:
2017,
Номер
46(30), С. 9721 - 9739
Опубликована: Янв. 1, 2017
This
perspective
highlights
recent
applications
of
Cp*CoIII
catalysts
in
C–H
functionalisation
protocols,
exemplifying
both
terminal
couplings
and
heterocycle
formation.
Organic & Biomolecular Chemistry,
Год журнала:
2019,
Номер
17(48), С. 10119 - 10141
Опубликована: Янв. 1, 2019
Ready
availability,
low
cost
and
toxicity
of
cobalt
salts
have
redirected
the
attention
researchers
away
from
noble
metals,
such
as
Pd,
Rh,
Ir,
towards
Co
in
field
C-H
functionalization.
In
this
context,
examples
Co-catalysed
functionalization
exponentially
grown
over
last
few
decades.
This
present
review
focuses
on
most
recent
developments
C(sp2)-H
C(sp3)-H
functionalizations.
Included
is
also
a
comprehensive
overview
enantioselective
transformations.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
58(6), С. 1684 - 1688
Опубликована: Ноя. 30, 2018
Bioorthogonal
late-stage
diversification
of
structurally
complex
peptides
has
enormous
potential
for
drug
discovery
and
molecular
imaging.
In
recent
years,
transition-metal-catalyzed
C-H
activation
emerged
as
an
increasingly
viable
tool
peptide
modification.
Despite
major
accomplishments,
these
strategies
largely
rely
on
expensive
palladium
catalysts.
We
herein
report
unprecedented
cobalt(III)-catalyzed
activation,
which
enables
the
direct
functionalization
peptides,
sets
stage
a
multicatalytic
activation/alkene
metathesis/hydrogenation
strategy
assembly
novel
cyclic
peptides.
Chemistry - A European Journal,
Год журнала:
2017,
Номер
23(64), С. 16115 - 16151
Опубликована: Июнь 22, 2017
Abstract
The
direct
introduction
of
alkenyl
groups
into
the
indole
framework
avoiding
its
preliminary
functionalization
can
be
carried
out
using
different
synthetic
strategies.
Transition‐metal
complexes
facilitate
C−H
activation
indoles
or
alkenes
allowing
an
efficient
Csp
2
‐
bond
formation.
hydroindolation
alkynes
catalyzed
by
same
metal
various
acidic
promoters
also
pursued
for
alkenylation
process.
Conjugate
addition
electron‐poor
and
condensation
carbonyl
derivatives
with
are
interest
this
purpose.
regiochemical
control
exploited
intrinsic
C‐3
reactivity
ring.
a
suitable
directing
group
at
nitrogen
atom
allows
preparation
C‐2
alkenylated
transition
reactions.
This
review
collects
fundamental
contributions
in
field
reported
literature
during
last
fifteen
years.
ACS Catalysis,
Год журнала:
2017,
Номер
7(10), С. 7296 - 7304
Опубликована: Сен. 12, 2017
An
efficient,
atom-economical,
and
regioselective
insertion
of
indoles
into
terminal
alkynes
has
been
realized
via
cobalt(III)-catalyzed
C–H
activation
under
mild
conditions,
leading
to
efficient
synthesis
α-gem-vinylindoles.
The
the
follows
a
rare
1,2-selectivity,
silyl
alkynes,
alkyl
propargyl
alcohols,
protected
amines
are
all
applicable.
mechanism
this
hydroarylation
system
studied
in
detail
by
combination
experimental
computational
approaches.
In
reaction
regioselectivity
is
dictated
steric
effects
alkyne
substituent,
especially
protonolysis
stage.
However,
for
amines,
selectivity
results
from
electronic
during
step,
with
being
insignificant
determination
selectivity.
internal
also
coupled
high
efficiency
but
low
regioselectivity.
Comparisons
cobalt,
rhodium,
iridium
catalysts
have
made
terms
reactivity,
both
cobalt
catalysts.