Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(15), С. 3710 - 3718
Опубликована: Янв. 1, 2024
Meeting
the
demand
for
efficient
photosensitizers
in
photodynamic
therapy
(PDT),
a
series
of
iridium(III)
complexes
decorated
with
silicane-modified
rhodamine
(Si-rhodamine)
was
meticulously
designed
and
synthesized.
These
demonstrate
exceptional
PDT
potential
owing
to
their
strong
absorption
near-infrared
(NIR)
spectrum,
particularly
responsive
808
nm
laser
stimulation.
This
feature
is
pivotal,
enabling
deep-penetration
excitation
overcoming
depth-related
challenges
clinical
applications.
The
molecular
structures
these
allow
reliable
tuning
singlet
oxygen
generation
NIR
excitation,
through
modification
cyclometalating
ligand.
Notably,
one
(4)
exhibits
remarkable
ROS
quantum
yield
0.69.
Advanced Healthcare Materials,
Год журнала:
2020,
Номер
9(6)
Опубликована: Янв. 29, 2020
Abstract
Developing
technologies
that
allow
the
simultaneous
diagnosis
and
treatment
of
cancer
(theragnostic)
has
been
quest
numerous
interdisciplinary
research
teams.
In
this
context,
nanomaterials
incorporating
prototypic
near
infrared
(NIR)‐light
responsive
heptamethine
cyanines
have
showing
very
promising
results
for
theragnostic.
The
precisely
engineered
features
these
endow
them
with
ability
to
achieve
a
high
tumor
accumulation,
enabling
tumor's
visualization
by
NIR
fluorescence
photoacoustic
imaging
modalities.
Upon
interaction
light,
tumor‐homed
cyanine‐incorporating
can
also
produce
photothermal/photodynamic
effect
spatio‐temporal
resolution
minimal
side
effects,
leading
an
improved
therapeutic
outcome.
This
progress
report
analyses
application
NIR‐light
(IR775,
IR780,
IR783,
IR797,
IR806,
IR808,
IR820,
IR825,
IRDye
800CW,
Cypate)
photothermal
therapy,
photodynamic
imaging.
Overall,
continuous
development
absorbing
will
cement
their
phototheragnostic
capabilities.
Chemical Science,
Год журнала:
2019,
Номер
10(22), С. 5766 - 5772
Опубликована: Янв. 1, 2019
An
oxygen
self-sufficient
NIR-responsive
nanoplatform
enhances
the
efficiency
of
synergistic
treatments
between
PDT
and
chemotherapy
in
hypoxic
tumors.
Inorganic Chemistry Frontiers,
Год журнала:
2019,
Номер
6(7), С. 1623 - 1638
Опубликована: Янв. 1, 2019
Diazido
Pt(iv)
complexes
with
a
general
formula
[Pt(N3)2(L)(L′)(OR)(OR′)]
are
new
generation
of
anticancer
prodrugs
designed
for
use
in
photoactivated
chemotherapy.
Pharmaceutics,
Год журнала:
2021,
Номер
13(6), С. 818 - 818
Опубликована: Май 31, 2021
Photodynamic
therapy
(PDT)
is
a
method
of
cancer
treatment
that
leads
to
the
disintegration
cells
and
has
developed
significantly
in
recent
years.
The
clinically
used
photosensitizers
are
primarily
porphyrin,
which
absorbs
light
red
spectrum
their
absorbance
maxima
relatively
short.
This
review
presents
group
compounds
derivatives
considered
be
potential
PDT.
Cyanine
dyes
typically
absorb
visible
near-infrared-I
(NIR-I)
range
(750–900
nm).
meta-analysis
comprises
current
studies
on
cyanine
dye
derivatives,
such
as
indocyanine
green
(so
far
solely
diagnostic
agent),
heptamethine
pentamethine
dyes,
squaraine
merocyanines
phthalocyanines.
wide
array
arises
from
structural
modifications
(e.g.,
halogenation,
incorporation
metal
atoms
or
organic
structures,
synthesis
lactosomes,
emulsions
conjugation).
All
following
aim
increase
solubility
aqueous
media,
enhance
phototoxicity,
decrease
photobleaching.
In
addition,
changes
introduce
new
features
like
pH-sensitivity.
involved
photodynamic
reactions
could
incorporated
into
sets
PDT
agents.
Chemical Science,
Год журнала:
2019,
Номер
10(9), С. 2785 - 2790
Опубликована: Янв. 1, 2019
A
theranostic
platform
enables
the
selective
visualization
of
H2S-rich
cancers
and
imaging-directed
on-demand
photodynamic
therapy
detected
while
leaving
normal
tissues
untouched.
ACS Applied Materials & Interfaces,
Год журнала:
2019,
Номер
11(48), С. 44961 - 44969
Опубликована: Ноя. 6, 2019
Developing
smart
photosensitizers
that
are
sensitive
to
tumor-specific
signals
for
minimal
side
effects
and
enhanced
antitumor
efficacy
is
a
tremendous
challenge
tumor
phototherapies.
Herein,
we
construct
nanoplatform
with
glutathione
(GSH)-activatable
mitochondria-targeted
pro-photosensitizer
encapsulated
by
ultrasensitive
pH-responsive
polymer
achieving
imaging-guided
photodynamic
therapy
(PDT).
The
GSH-activatable
pro-photosensitizer,
di-cyanine
(DCy7),
has
been
synthesized
where
two
cyanine
moieties
covalently
conjugated
disulfide
bond,
the
hydrophobic
DCy7
further
an
amphiphilic
diblock
copolymer
POEGMA-b-PDPA
form
P@DCy7
nanoparticles.
Upon
endocytosis
cancer
cells,
nanoparticles
dissociate
at
endosome
first
then
released
cytoplasm
subsequently
activated
high
concentration
of
GSH,
finally
targets
mitochondria
organelle-targeted
PDT.
Moreover,
intracellular
antioxidant
GSH
consumed
during
activation
procedure
beneficial
efficient
These
display
selective
phototoxicity
against
cells
(HepG2
or
4T1
cells)
over
normal
(BEAS-2B
in
vitro,
their
PDT
confirmed
tumor-bearing
mice.
Thus,
allow
accurate
highly
effects,
providing
attractive
precise
Bioactive Materials,
Год журнала:
2020,
Номер
6(3), С. 794 - 809
Опубликована: Сен. 29, 2020
Cyanine
is
a
meritorious
fluorogenic
core
for
the
construction
of
fluorescent
probes
and
its
phototherapeutic
potential
has
been
enthusiastically
explored
as
well.
Alternatively,
covalent
conjugation
cyanine
with
other
potent
therapeutic
agents
not
only
boosts
efficacy
but
also
broadens
modality.
Herein,
we
summarize
miscellaneous
cyanine-therapeutic
agent
conjugates
in
cancer
theranostics
from
literature
published
between
2014
2020.
The
application
scenarios
such
theranostic
covered
common
modalities,
including
chemotherapy,
phototherapy
targeted
therapy.
Besides,
that
serve
nanocarriers
drug
delivery
are
introduced
In
an
additional
section,
analyze
these
clinical
translation.
Overall,
this
review
aimed
to
stimulate
research
interest
exploring
unattempted
novel
strategies
hopefully,
accelerate
translation
field.
Chemical Science,
Год журнала:
2022,
Номер
13(34), С. 9921 - 9926
Опубликована: Янв. 1, 2022
Sonodynamic
therapy
(SDT)
has
unique
advantages
in
deep
tumour
ablation
due
to
its
penetration
depth,
showing
great
preclinical
and
clinical
potential.
Herein,
a
platinum(ii)-cyanine
complex
been
designed
investigate
potential
as
SDT
anticancer
agent.
It
generates
singlet
oxygen
(1O2)
under
ultrasound
(US)
irradiation
or
light
irradiation,
exhibits
US-cytotoxicity
breast
cancer
4T1
cells
but
with
negligible
dark-cytotoxicity.
Mechanistic
investigations
reveal
that
Pt-Cy
reduces
the
cellular
GSH
GPX4,
triggers
cell
ferroptosis
US
irradiation.
The
metabolomics
analysis
illustrates
upon
treatment
significantly
dysregulates
glutathione
metabolism,
finally
induces
ferroptosis.
In
vivo
studies
further
demonstrate
inhibits
tumor
growth
efficiency
for
is
better
than
PDT
vivo.
This
first
example
of
platinum(ii)
complexes
sonodynamic
therapy.
work
extends
biological
applications
metal
from
SDT.
