Abstract
A
general
and
modular
protocol
is
reported
for
olefin
difunctionalization
through
mechanochemistry,
facilitated
by
cooperative
radical
ligand
transfer
(RLT)
electron
catalysis.
Utilizing
mechanochemical
force
catalytic
amounts
of
2,2,6,6‐tetramethylpiperidinyloxyl
(TEMPO),
ferric
nitrate
can
leverage
nitryl
radicals,
nitrooxy‐functional
group
via
RLT,
mediate
an
catalysis
cycle
under
room
temperature.
diverse
range
activated
unactivated
alkenes
exhibited
chemo‐
regioselective
1,2‐nitronitrooxylation
solvent‐free
or
solvent‐less
conditions,
showcasing
excellent
functional
tolerance.
Mechanistic
studies
indicated
a
significant
impact
mechanochemistry
highlighted
the
nature
this
nitrative
process.
ChemSusChem,
Год журнала:
2021,
Номер
14(10), С. 2145 - 2162
Опубликована: Апрель 9, 2021
In
recent
years,
mechanochemistry
has
been
growing
into
a
widely
accepted
alternative
for
chemical
synthesis.
addition
to
their
efficiency
and
practicality,
mechanochemical
reactions
are
also
recognized
sustainability.
The
association
between
Green
Chemistry
often
originates
from
the
solvent-free
nature
of
most
protocols,
which
can
reduce
waste
production.
However,
satisfies
more
than
one
Principles
Chemistry.
this
Review
we
will
present
series
examples
that
clearly
illustrate
how
significantly
contribute
fulfillment
in
holistic
manner.
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
363(5), С. 1246 - 1271
Опубликована: Янв. 21, 2021
Abstract
Mechanochemical
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
salient
green
approach
because
its
wide
applications
towards
academic
and
industrial
chemical
communities
in
sustainable
solvent‐free/solvent‐less
processes.
Liquid‐assisted
(LAG)
an
extension
traditional
solvent‐free
mechanochemical
techniques
which
small
amount
liquid
is
used
additive
to
enhance
and/or
control
reactivity,
has
been
fruitfully
applied
the
screening
inclusion
compounds,
cocrystals,
salts,
solvates,
polymorphs.
However,
utilization
this
important
technique
synthesis
pharmaceutically
biologically
relevant
targets
was
not
adequately
investigated.
This
review
article
summarizes
overview
latest
development
LAG
approaches
active
pharmaceutical
ingredients
(API)
drug‐like
fragments,
highlights
superiority
versus
conventional
syntheses.
magnified
image
Advanced Materials,
Год журнала:
2022,
Номер
34(46)
Опубликована: Янв. 11, 2022
Abstract
Mechanochemistry
with
solvent‐free
and
environmentally
friendly
characteristics
is
one
of
the
most
promising
alternatives
to
traditional
liquid‐phase‐based
reactions,
demonstrating
epoch‐making
significance
in
realization
different
types
chemistry.
utilizes
mechanical
energy
promote
physical
chemical
transformations
design
complex
molecules
nanostructured
materials,
encourage
dispersion
recombination
multiphase
components,
accelerate
reaction
rates
efficiencies
via
highly
reactive
surfaces.
In
particular,
mechanochemistry
deserves
special
attention
because
it
capable
endowing
materials
unique
properties.
Herein,
latest
advances
progress
for
preparation
modification
are
reviewed.
An
outline
basic
knowledge,
methods,
mechanochemical
strategies
presented,
distinguishing
this
review
from
reviews
that
only
focus
on
ball‐milling.
Next,
followed
by
a
detailed
insightful
discussion
mechanochemistry‐involved
conversion
storage
applications.
The
comprehensively
covers
aspects
mechanical/optical/chemical
electrical
energy.
Finally,
next‐generation
advanced
proposed.
This
intended
bring
frontline
guide
burgeoning
field
interdisciplinary
research
developing
greener
force.
Chemistry - A European Journal,
Год журнала:
2021,
Номер
27(38), С. 9721 - 9726
Опубликована: Апрель 1, 2021
Abstract
Recent
research
endeavors
have
established
that
the
mechanochemical
activation
of
piezoelectric
materials
can
open
new
avenues
in
redox
chemistry.
Impact
forces,
such
as
those
imparted
by
a
ball
mill,
been
shown
to
transform
barium
titanate
(BaTiO
3
)
into
highly
polarized
state,
which
then
donate
an
electron
suitable
oxidant
and
receive
from
reductant,
mimicking
photoredox
catalytic
cycles.
Proof‐of‐concept
studies
elucidated
mechanoredox
chemistry
holds
great
potential
sustainable
efficient
radical‐based
synthesis.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(11), С. 4243 - 4260
Опубликована: Янв. 1, 2022
Reactive
extrusion
provides
a
scale-up
opportunity
to
turn
mechanochemical
process
from
ball-mill
into
continuous
flow.
This
tutorial
review
summarises
some
of
the
early
ground-breaking
work
in
this
area.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(44)
Опубликована: Апрель 28, 2023
Mechanochemistry
provides
an
environmentally
benign
platform
to
develop
more
sustainable
chemical
processes
by
limiting
raw
materials,
energy
use,
and
waste
generation
while
using
physically
smaller
equipment.
A
continuously
growing
research
community
has
steadily
showcased
examples
of
beneficial
mechanochemistry
applications
at
both
the
laboratory
preparative
scale.
In
contrast
solution-based
chemistry,
mechanochemical
have
not
yet
been
standardized,
thus
scaling
up
is
still
a
nascent
discipline.
The
purpose
this
Minireview
highlight
similarities,
differences
challenges
various
approaches
that
successfully
applied
for
range
scales.
We
hope
provide
discussion
starting
point
those
interested
in
further
developing
commercial
use
and/or
industrialisation.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(50), С. 22570 - 22576
Опубликована: Сен. 14, 2020
Abstract
The
application
of
piezoelectricity
for
the
generation
trifluoromethyl
(CF
3
)
radicals
is
reported
together
with
development
a
method
mechanochemical
C−H
trifluoromethylation
aromatic
compounds.
As
compared
to
conventional
solution‐based
approaches,
this
mechanoredox
enables
cleaner
and
more
sustainable
access
wide
range
trifluoromethylated
N‐heterocycles
peptides,
which
are
important
structural
motifs
in
modern
drug
discovery.
This
study
thus
represents
an
milestone
future
applications
systems
medicinal
pharmaceutical
science.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(22), С. 9884 - 9889
Опубликована: Апрель 27, 2020
Palladium-catalyzed
Suzuki–Miyaura
cross-coupling
reactions
of
liquid,
unbiased
dibromoarenes
under
mechanochemical
conditions
selectively
afford
the
monoarylated
products.
The
lower
reactivity
crystalline
products
relative
to
liquid
starting
materials
should
be
attributed
predominantly
low
diffusion
efficiency
former
in
reaction
mixture,
which
results
a
selective
monoarylation.
present
study
sheds
light
on
novel
approach
using
situ
phase
transitions
solids
design
organic
transformations
that
are
difficult
achieve
via
conventional
solution-based
synthesis.
Chemical Science,
Год журнала:
2020,
Номер
11(29), С. 7578 - 7584
Опубликована: Янв. 1, 2020
We
present
a
rapid
and
readily
scalable
methodology
for
the
mechanosynthesis
of
diverse
metal–organic
frameworks
(MOFs)
in
absence
milling
media
typically
required
other
types
mechanochemical
syntheses.
