C–H activation

Nature Reviews Methods Primers, Год журнала: 2021, Номер 1(1)

Опубликована: Июнь 17, 2021

Язык: Английский

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Recent advances in the synthesis of axially chiral biarylsviatransition metal-catalysed asymmetric C–H functionalization

Chemical Communications, Год журнала: 2019, Номер 55(59), С. 8514 - 8523

Опубликована: Янв. 1, 2019

Recent advances in the synthesis of axially chiral biarylsviatransition metal-catalysed asymmetric C–H functionalization are reported.

Язык: Английский

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Transition Metal‐Catalyzed Enantioselective C−H Functionalization via Chiral Transient Directing Group Strategies

Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(45), С. 19773 - 19786

Опубликована: Июль 20, 2020

Abstract Transition metal‐catalyzed enantioselective functionalization of C−H bond, the most abundant functionality in organic molecules, has emerged as an expedient synthetic approach to streamline synthesis complex chiral molecules. Despite significant progress, traditional directing group‐enabled strategies require additional steps for installation and removal groups from target molecule. The recently developed asymmetric using transient ( c TDGs) offers a promising alternative that can circumvent this obstacle therefore simplify process. In Minireview, we briefly discuss advent recent advances emerging concept, with emphasis on discussing creation various stereogenic centers developments TDGs. Applications natural product ligand derivatizations are also discussed. We hope Minireview will highlight great potential strategy help inspire further endeavors.

Язык: Английский

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Strategies and mechanisms of metal–ligand cooperativity in first-row transition metal complex catalysts

Chemical Society Reviews, Год журнала: 2020, Номер 49(24), С. 8933 - 8987

Опубликована: Янв. 1, 2020

The use of metal–ligand cooperation (MLC) by transition metal bifunctional catalysts has emerged at the forefront homogeneous catalysis science.

Язык: Английский

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Enantioselective Pallada‐Electrocatalyzed C−H Activation by Transient Directing Groups: Expedient Access to Helicenes

Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(32), С. 13451 - 13457

Опубликована: Апрель 3, 2020

Abstract Asymmetric pallada‐electrocatalyzed C−H olefinations were achieved through the synergistic cooperation with transient directing groups. The electrochemical, atroposelective activations realized high position‐, diastereo‐, and enantio‐control under mild reaction conditions to obtain highly enantiomerically‐enriched biaryls fluorinated N−C axially chiral scaffolds. Our strategy provided expedient access to, among others, novel BINOLs, dicarboxylic acids helicenes of value asymmetric catalysis. Mechanistic studies by experiments computation key insights into catalyst's mode action.

Язык: Английский

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Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(24), С. 13198 - 13224

Опубликована: Июль 16, 2020

The creation of new chiral ligands capable providing high stereocontrol in metal-catalyzed reactions is crucial modern organic synthesis. production bioactive molecules as single enantiomers increasingly required, and asymmetric catalysis with metal complexes constitutes one the most efficient synthetic strategies to access optically active compounds. Herein we offer a historical overview on development derivatives ubiquitous cyclopentadienyl ligand (CpX ), detail their successful application broad range transformations. Those include functionalization challenging C-H bonds beyond, giving an extensive catalogue valuable molecules. A critical comparison existing families, design, synthesis, complexation different metals also provided. In addition, future research directions are discussed further enhance performance CpX enantioselective catalysis.

Язык: Английский

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Transition Metal Catalyzed Enantioselective C(sp²)–H Bond Functionalization

ACS Catalysis, Год журнала: 2020, Номер 10(23), С. 13748 - 13793

Опубликована: Ноя. 12, 2020

Direct catalytic transformation of C–H bonds to new functionalities has provided a powerful strategy synthesize complex molecular scaffolds in straightforward way. Unstinting efforts the synthetic community have helped overcome long-standing major challenge regioselectivity by introducing directing group concept. However, full potential cannot be realized unless activated are stereochemically controlled. The enantioselective bond functionalization could provide an imperative tool for sustainable way synthesizing chiral scaffolds. Despite intrinsic challenges achieving stereocontrol, developed different tools order achieve stereoselective functionalization. In this review, we discuss remarkable recent advances emerging area C(sp2)–H highlight and opportunities, emphasizing techniques so far.

Язык: Английский

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Diverse Approaches for Enantioselective C−H Functionalization Reactions Using Group 9 Cp^xM^III Catalysts

Chemistry - A European Journal, Год журнала: 2020, Номер 26(33), С. 7346 - 7357

Опубликована: Янв. 29, 2020

Transition-metal-catalyzed C-H functionalization reactions with Cp*MIII catalysts (M=Co, Rh, Ir) have found a wide variety of applications in organic synthesis. Albeit the intrinsic difficulties achieving catalytic stereocontrol using these due to their lack additional coordination sites for external chiral ligands and conformational flexibility Cp ligand, enantioselective Group 9 metal triad Cp-type been intensively studied since 2012. In this minireview, progress according type catalyst used are summarized discussed. The development Cpx complexes thereof, artificial metalloenzymes, carboxylate-assisted activations, alkylations assisted by carboxylic acids or sulfonates, transient directing groups

Язык: Английский

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Enhanced Photoelectrocatalytic Activities for CH₃OH‐to‐HCHO Conversion on Fe₂O₃/MoO₃: Fe‐O‐Mo Covalency Dominates the Intrinsic Activity

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(17), С. 9546 - 9552

Опубликована: Фев. 9, 2021

Abstract The catalytic conversion of alcohols under mild conditions is a great challenge because it constrained by low selectivity and activity. Herein, we demonstrate hollow nanotube Fe 2 O 3 /MoO heterojunction (FeMo‐2) for the photoelectrocatalytic small‐molecule alcohols. Experimental theoretical analyses reveal that optical carrier transfer rate enhanced constructing interfacial internal electric fields Fe‐O‐Mo charge channels. For formox process, heterojunctions possess superior HCHO‐selective reaction paths free energy transitions, optimizing HCHO enhancing reactivity. FeMo‐2 shows greatly improved performance compared to single ; photocurrent density reaches 0.66 mA cm −2 , which 3.88 times (0.17 ), Faraday efficiency CH OH‐to‐HCHO 95.7 %. This work may deepen our understanding separation has potential production reactions other at cryogenic temperatures.

Язык: Английский

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Generation of Heteroatom Stereocenters by Enantioselective C–H Functionalization

ACS Catalysis, Год журнала: 2019, Номер 9(10), С. 9164 - 9177

Опубликована: Авг. 30, 2019

C–H functionalization has been established as an efficient way to generate molecular complexity. The formation of stereogenic carbon atoms by asymmetric seen tremendous progress over the past decade. More recently, direct catalytic modification bonds powerfully applied noncarbon centers, which constitute a key design element biologically active molecules and chiral ligands for catalysis. This area was opened seminal report describing enantioselective silicon stereocenter. It rapidly expanded with advances in phosphorus(V) centers. Moreover, routes sulfur oxidation states IV (sulfoxides) VI (sulfoximines) have disclosed. Herein, we discuss methods using selective remote heteroatom center via inner-sphere activation mechanism.

Язык: Английский

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