Abstract
The
combination
of
organometallic
C−H
activation
and
electro‐catalysis
has
emerged
as
a
potent
synthetic
technique
for
various
molecular
scaffolds
since
it
avoids
the
use
harmful
expensive
chemical
oxidants
in
stoichiometric
amounts.
Moreover,
pre‐functionalization
substrates
is
not
required
newer
ways
to
perform
metal‐catalyzed
reactions
are
possible.
Here,
we
have
discussed
eletrochemically
driven
acyloxylation,
acetoxylation,
oxygenation,
acylation,
amination,
alkylation,
halogenation,
olefinations
C−H/N−H
annulation
using
transition‐metal‐catalyst
such
Ru,
Rh,
Pd,
Co,
Ni,
Ir,
Cu,
Mn
Au
by
anodic
oxidation,
followed
reductive
elimination
form
corresponding
C−O,
C−C,
C−N
C−X
(X=Cl,
Br,
S
etc.)
bonds.
This
review
covers
recent
developments
transition‐metal‐catalyzed
electrochemical
from
2007
until
2022.
Chemical Reviews,
Год журнала:
2021,
Номер
122(3), С. 3180 - 3218
Опубликована: Ноя. 19, 2021
Synthetic
organic
electrosynthesis
has
grown
in
the
past
few
decades
by
achieving
many
valuable
transformations
for
synthetic
chemists.
Although
electrocatalysis
been
popular
improving
selectivity
and
efficiency
a
wide
variety
of
energy-related
applications,
last
two
decades,
there
much
interest
to
develop
conceptually
novel
transformations,
selective
functionalization,
sustainable
reactions.
This
review
discusses
recent
advances
combination
electrochemistry
homogeneous
transition-metal
catalysis
synthesis.
The
enabling
mechanistic
studies
are
presented
alongside
advantages
as
well
future
directions
address
challenges
metal-catalyzed
electrosynthesis.
Chemical Reviews,
Год журнала:
2022,
Номер
122(24), С. 17479 - 17646
Опубликована: Окт. 14, 2022
Alkenes
and
their
derivatives
are
featured
widely
in
a
variety
of
natural
products,
pharmaceuticals,
advanced
materials.
Significant
efforts
have
been
made
toward
the
development
new
practical
methods
to
access
this
important
class
compounds
by
selectively
activating
alkenyl
C(sp2)–H
bonds
recent
years.
In
comprehensive
review,
we
describe
state-of-the-art
strategies
for
direct
functionalization
sp2
C–H
C–F
until
June
2022.
Moreover,
metal-free,
photoredox,
electrochemical
also
covered.
For
clarity,
review
has
divided
into
two
parts;
first
part
focuses
on
currently
available
using
different
alkene
as
starting
materials,
second
describes
bond
easily
accessible
gem-difluoroalkenes
material.
This
includes
scope,
limitations,
mechanistic
studies,
stereoselective
control
(using
directing
groups
well
metal-migration
strategies),
applications
complex
molecule
synthesis
where
appropriate.
Overall,
aims
document
considerable
advancements,
current
status,
emerging
work
critically
summarizing
contributions
researchers
working
fascinating
area
is
expected
stimulate
novel,
innovative,
broadly
applicable
functionalizations
coming
Chemical Reviews,
Год журнала:
2023,
Номер
123(19), С. 11269 - 11335
Опубликована: Сен. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
Organic Chemistry Frontiers,
Год журнала:
2020,
Номер
8(5), С. 1085 - 1101
Опубликована: Дек. 23, 2020
Recent
advances
during
2015–2020
in
the
field
of
metal-catalyzed
olefinic
C–H
functionalization
are
organized
according
to
metal
center
catalyst,
with
an
emphasis
on
similarities
and
differences
among
different
catalysts.
Green Chemistry,
Год журнала:
2020,
Номер
22(15), С. 4849 - 4870
Опубликована: Янв. 1, 2020
Herein,
electrochemical
annulations
involving
mediators
and
mediator-free
conditions
have
been
discussed.
Also,
the
use
of
sacrificial
electrodes
has
explored.
Chemistry - A European Journal,
Год журнала:
2021,
Номер
27(49), С. 12453 - 12508
Опубликована: Май 26, 2021
Synthetic
organic
chemistry
has
witnessed
a
plethora
of
functionalization
and
defunctionalization
strategies.
In
this
regard,
C-H
been
at
the
forefront
due
to
multifarious
applications
in
development
simple
complex
molecular
architectures
holds
brilliant
prospect
drug
discovery.
Despite
explored
tremendously
by
chemists,
strategy
still
enjoys
employment
novel
metal
catalysts
as
well
metal-free
ligands.
Moreover,
switch
photo-
electrochemistry
widened
our
understanding
alternative
pathways
via
which
reaction
can
proceed
these
strategies
have
garnered
prominence
when
applied
activation.
chemists
foraging
for
new
directing
groups
templates
selective
activation
bonds
from
myriad
carbon-hydrogen
aromatic
aliphatic
systems.
As
matter
fact,
varying
groups,
scientists
found
answer
challenge
distal
bond
remained
an
obstacle
very
long
time.
These
frequently
harnessed
selectively
activating
natural
products,
drugs,
macromolecules
decorated
with
multiple
bonds.
This
itself
was
before
commencement
field
site
other
than
targeted
could
modify
hamper
biological
activity
pharmacophore.
Total
synthesis
pharmacophore
often
faces
difficulty
superfluous
steps
towards
functionalization.
solved
late-stage
simply
harnessing
green
conditions
seen
light
past
few
decades
rising
concern
about
environmental
issues.
Therefore,
or
usage
non-toxic
metals
recently
showcased
number
elegant
works.
Also,
research
across
world
are
developing
rational
group
free
non-directed
protocols
that
just
guided
review
encapsulates
works
pertinent
discusses
science
devoted
it
fundamental
level.
gives
readers
broad
how
work,
execution
various
catalysts,
groups.
not
only
helps
budding
scientist
his/her
but
also
matured
mind
searching
out
A
detailed
picture
its
progress
time
portrayed
lucid
scientific
language
motive
inculcate
educate
minds
beautiful
overview
most
relevant
significant
era.
The
unique
trait
is
description
classification
their
utility
over
wide
substrate
scope.
allows
experimental
chemist
understand
applicability
domain
employ
any
substrate.
