Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(45)
Опубликована: Окт. 2, 2023
Light
olefins
are
abundantly
manufactured
in
the
petroleum
industry
and
thus
represent
ideal
starting
materials
for
modern
chemical
synthesis.
Selective
divergent
transformations
of
feedstock
light
to
value-added
chemicals
highly
sought-after
but
remain
challenging.
Herein
we
report
an
exceptionally
regioselective
carbonickelation
alkenes
followed
by
situ
trapping
with
three
types
nucleophiles,
namely
a
reductant,
base,
or
Grignard
reagent.
This
protocol
enables
efficient
1,2-hydrofunctionalization,
dicarbofunctionalization,
branched-selective
Heck-type
cross-coupling
aryl
alkenyl
reagents
streamline
access
diverse
alkyl
arenes
complex
alkenes.
Harnessing
bulky
N-heterocyclic
carbene
ligands
acenaphthyl
backbones
nickel
catalysts
is
crucial
attain
high
reactivity
selectivity.
strategy
provides
rare,
modular,
platform
upgrading
expected
find
broad
applications
medicinal
chemistry
industrial
processes.
ACS Catalysis,
Год журнала:
2024,
Номер
15(1), С. 72 - 80
Опубликована: Дек. 13, 2024
Despite
significant
progress
in
the
catalytic
asymmetric
1,4-additions
between
various
Michael
donors
and
acceptors,
exploration
of
organohalide
remains
elusive.
Herein,
we
report
Pd(0)-catalyzed
intramolecular
vinyl/aryl
iodides
to
α,β-unsaturated
hydrazones,
featuring
situ-formed
hydrazone
acid/base-tuned
reaction
pathways.
Due
its
strong
coordination
ability,
is
capable
steering
C–C
bond
formation
follow
1,4-addition
mechanism
instead
conventional
alkene
insertion,
thus
enabling
generation
vinylhydrazinyl–Pd2+
species
via
Zimmerman–Traxler
chairlike
transition
state.
Notably,
this
preferentially
undergoes
protonation
under
acidic
conditions,
furnishing
a
reductive
Heck
with
aid
native
hydrazine
reductant,
while
it
susceptible
β-HN
elimination
basic
conditions
achieve
denitrogenative
reaction.
The
protocol
affords
highly
enantioselective
access
diverse
heterocycles,
groups
poised
for
further
chemical
manipulations.
Organic Letters,
Год журнала:
2022,
Номер
24(12), С. 2376 - 2380
Опубликована: Март 23, 2022
Herein,
we
describe
a
nickel-catalyzed
reductive
deaminative
arylalkylation
of
tethered
alkenes
with
pyridinium
salts
as
C(sp3)
electrophiles.
This
two-component
dicarbofunctionalization
reaction
enables
the
efficient
synthesis
various
benzene-fused
cyclic
compounds
bearing
all-carbon
quaternary
centers.
The
approach
presented
in
this
paper
proceeds
under
mild
conditions,
tolerating
wide
variety
functional
groups
and
heterocycles.
It
has
been
used
to
functionalize
complicated
molecules
at
late
stage.
Composites science and technology,
Год журнала:
2022,
Номер
unknown, С. 223 - 266
Опубликована: Янв. 1, 2022
Nanoscience
and
nanotechnology
have
revolutionized
organic
catalysis,
increasing
the
efficiency
of
these
reactions
reducing
their
environmental
impact.
Particularly,
carbon
nanotubes
are
widely
used
in
many
such
as
C–C
couplings,
hydrogenations,
alkane
dehydrogenations,
transesterifications
oxidations.
Excellent
results
been
obtained
terms
synthesis
catalysts,
reaction
yields,
selectivity,
reusability.
In
this
review,
we
provide
a
general
overview
design,
synthesis,
use
catalysts
catalytic
supports,
along
with
main
strategies
for
surface
functionalization
doping
heteroatoms.
Concluding
considerations
from
authors'
perspective
provided,
regarding
promising
materials
challenges
to
be
faced
near
future.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(45)
Опубликована: Окт. 2, 2023
Light
olefins
are
abundantly
manufactured
in
the
petroleum
industry
and
thus
represent
ideal
starting
materials
for
modern
chemical
synthesis.
Selective
divergent
transformations
of
feedstock
light
to
value-added
chemicals
highly
sought-after
but
remain
challenging.
Herein
we
report
an
exceptionally
regioselective
carbonickelation
alkenes
followed
by
situ
trapping
with
three
types
nucleophiles,
namely
a
reductant,
base,
or
Grignard
reagent.
This
protocol
enables
efficient
1,2-hydrofunctionalization,
dicarbofunctionalization,
branched-selective
Heck-type
cross-coupling
aryl
alkenyl
reagents
streamline
access
diverse
alkyl
arenes
complex
alkenes.
Harnessing
bulky
N-heterocyclic
carbene
ligands
acenaphthyl
backbones
nickel
catalysts
is
crucial
attain
high
reactivity
selectivity.
strategy
provides
rare,
modular,
platform
upgrading
expected
find
broad
applications
medicinal
chemistry
industrial
processes.
