Enzyme‐Photocatalyst Tandem Microrobot Powered by Urea for Escherichia coli Biofilm Eradication

Small, Год журнала: 2022, Номер 18(36)

Опубликована: Фев. 5, 2022

Abstract Urinary‐based infections affect millions of people worldwide. Such bacterial are mainly caused by Escherichia coli (E. coli) biofilm formation in the bladder and/or urinary catheters. Herein, authors present a hybrid enzyme/photocatalytic microrobot, based on urease‐immobilized TiO 2 /CdS nanotube bundles, that can swim urea as biocompatible fuel and respond to visible light. Upon illumination for h, these microrobots able remove almost 90% biofilm, due generation reactive radicals, while bare photocatalysts (non‐motile) or urease‐coated dark do not show any toxic effect. These results indicate synergistic effect between self‐propulsion provided enzyme photocatalytic activity induced under light stimuli. This work provides photo‐biocatalytic approach design efficient light‐driven with promising applications microbiology biomedicine.

Язык: Английский

---

Cascade Catalytically Released Nitric Oxide‐Driven Nanomotor with Enhanced Penetration for Antibiofilm

Small, Год журнала: 2022, Номер 18(52)

Опубликована: Ноя. 7, 2022

Nanodrugs are becoming increasingly important in the treatment of bacterial infection, but their low penetration ability to biofilm is still main challenge hindering therapeutic effect. Herein, nitric oxide (NO)-driven nanomotor based on L-arginine (L-Arg) and gold nanoparticles (AuNPs) loaded dendritic mesoporous silica (AG-DMSNs) fabricated. AG-DMSNs have characteristics cascade catalytic reaction, where glucose first catalyzed by asymmetrically distributed AuNPs with oxidase (GOx)- mimic property, which results unilateral production hydrogen peroxide (H2 O2 ). Then, L-Arg oxidized produced H2 release NO, leading self-propelled movement. It found that active movement promotes penetrate biofilm, thus achieving good clearance vitro. More importantly, can eliminate methicillin-resistant Staphylococcus aureus (MRSA) vivo without causing damage normal tissues. This provides a new platform for infections.

Язык: Английский

---

Task‐Specific Janus Materials in Heterogeneous Catalysis

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(39)

Опубликована: Июнь 7, 2022

Janus materials are anisotropic nano- and microarchitectures with two different faces consisting of distinguishable or opposite physicochemical properties. In parallel the discovery new methods for fabrication these materials, decisive progress has been made in their application, example, biological science, catalysis, pharmaceuticals, and, more recently, battery technology. This Minireview systematically covers recent significant achievements application task-specific nanomaterials as heterogeneous catalysts various types chemical reactions, including reduction, oxidative desulfurization dye degradation, asymmetric biomass transformation, cascade oxidation, transition-metal-catalyzed cross-coupling electro- photocatalytic well gas-phase reactions. Finally, an outlook on possible future applications is given.

Язык: Английский

---

Multimodal‐Driven Magnetic Microrobots with Enhanced Bactericidal Activity for Biofilm Eradication and Removal from Titanium Mesh

Advanced Materials, Год журнала: 2023, Номер 35(23)

Опубликована: Март 30, 2023

Modern micro/nanorobots can perform multiple tasks for biomedical and environmental applications. Particularly, magnetic microrobots be completely controlled by a rotating field their motion powered without the use of toxic fuels, which makes them most promising application. Moreover, they are able to form swarms, allowing specific at larger scale than single microrobot. In this work, developed composed halloysite nanotubes as backbone iron oxide (Fe3 O4 ) nanoparticles material propulsion covered these with polyethylenimine load ampicillin prevent from disassembling. These exhibit multimodal robots well in swarms. addition, transform tumbling spinning vice-versa, when swarm mode change vortex ribbon back again. Finally, is used penetrate disrupt extracellular matrix Staphylococcus aureus biofilm colonized on titanium mesh bone restoration, improves effect antibiotic's activity. Such removal medical implants could reduce implant rejection improve patients' well-being.

Язык: Английский

---

Near‐Infrared Light‐Driven Mesoporous SiO₂/Au Nanomotors for Eradication of Pseudomonas aeruginosa Biofilm

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(13)

Опубликована: Фев. 3, 2023

Bacterial biofilms are linked to several diseases and cause resistant chronic infections in immune-compromised patients. Nanomotors comprise a new field of research showing great promise within biomedicine but pose challenges terms biocompatibility. propelled by thermophoresis could overcome this challenge, as they leave no waste product during propulsion. In study, mesoporous-silica nanoparticles coated with thin layer gold make nanomotors, which can be driven near-infrared (NIR) light irradiation. The prepared mesoporous SiO

Язык: Английский

---

Tailoring Functional Micromotors for Sensing

Research, Год журнала: 2023, Номер 6

Опубликована: Янв. 1, 2023

Micromotors are identified as a promising candidate in the field of sensing benefiting from their capacity autonomous movement. Here, review on development tailoring micromotors for is presented, covering propulsion mechanisms and strategies to applications. First, we concisely summarize mechanism involving fuel-based fuel-free introducing principles. Then, emphasis laid stratagems including speed-based strategy, fluorescence-based other strategies. We listed typical examples different stratagems. After that, introduce applications fields environmental science, food safety, biomedical fields. Finally, discuss challenges prospects tailored sensing. believe that this comprehensive can help readers catch research frontiers thus burst out new ideas.

Язык: Английский

---

Nanotechnology based Therapeutic Approaches: An Advanced Strategy to Target the Biofilm of ESKAPE Pathogens

Materials Advances, Год журнала: 2023, Номер 4(12), С. 2544 - 2572

Опубликована: Янв. 1, 2023

Nanotechnology based therapeutic approaches are a promising strategy to target biofilm-related infections caused by ESKAPE pathogens.

Язык: Английский

---

Construction of intelligent moving micro/nanomotors and their applications in biosensing and disease treatment

Theranostics, Год журнала: 2023, Номер 13(9), С. 2993 - 3020

Опубликована: Янв. 1, 2023

Micro/nanomotors are containers that pass through liquid media and carry cargo.Because they tiny, micro/nanomotors exhibit excellent potential for biosensing disease treatment applications.However, their size also makes overcoming random Brownian forces very challenging moving on targets.Additionally, to achieve desired practical applications, the expensive materials, short lifetimes, poor biocompatibility, complex preparation methods, side effects of must be addressed, adverse evaluated both in vivo applications.This has led continuous development key materials driving micro/nanomotors.In this work, we review working principles micro/nanomotors.Metallic nonmetallic nanocomplexes, enzymes, living cells explored as micro/nanomotors.We consider exogenous stimulations endogenous substance conditions micro/nanomotor motions.The discussion focuses applications biosensing, treating cancer gynecological diseases, assisted fertilization.By addressing shortcomings, propose directions further developing applying micro/nanomotors.

Язык: Английский

---

MOF-based micro/nanomotors (MOFtors): Recent progress and challenges

Coordination Chemistry Reviews, Год журнала: 2023, Номер 495, С. 215372 - 215372

Опубликована: Авг. 10, 2023

Язык: Английский

---

Cascade-driven nanomotors promote diabetic wound healing by eradicating MRSA biofilm infection

Chemical Engineering Journal, Год журнала: 2024, Номер 481, С. 148790 - 148790

Опубликована: Янв. 13, 2024

Язык: Английский

---