Photothermal Nanozyme‐Based Microneedle Patch against Refractory Bacterial Biofilm Infection via Iron‐Actuated Janus Ion Therapy

Advanced Materials, Год журнала: 2022, Номер 34(51)

Опубликована: Окт. 14, 2022

Owing to high antibiotic resistance and thermotolerance, bacterial biofilm infections (BBIs) are refractory elimination. Iron is essential for growth metabolism, bacteria can thus accumulate iron from surrounding cells maintain formation survival. Consequently, deficiency in the microenvironment (BME) leads functional failure of innate immune cells. Herein, a novel antibiofilm strategy iron-actuated Janus ion therapy (IJIT) proposed regulate metabolism both A BME-responsive photothermal microneedle patch (FGO@MN) synthesized by Fe3 O4 nanoparticles on graphene oxide nanosheets then encapsulated methacrylated hyaluronic acid needle tips. The catalytic product ·OH FGO@MN BME disrupts heat-shock proteins, coercing thermal sensitization. As synergistic mild treatment triggers uptake, intracellular overload further induces ferroptosis-like death. Moreover, iron-nourished neutrophils around be rejuvenated reactivating suppressed function. Thus, more than 95% BBIs elimination achieved combining heat stress-triggered interference with iron-nutrient reactivation. Furthermore, vivo experiments validate scavenging BBI after 15 days, suggesting promising perspective IJIT future clinical application.

Язык: Английский

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Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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Cu Single Atom Nanozyme Based High‐Efficiency Mild Photothermal Therapy through Cellular Metabolic Regulation

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(50)

Опубликована: Окт. 20, 2022

Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP-silencing induced PTT. On one hand, LIK066 inhibits glucose uptake by shutting sodium-dependent transporter (SGLT) "valve", effectively blocking energy source adenosine triphosphate (ATP) generation. Without sufficient energy, cancer cells cannot synthesize HSPs. other SAzyme presents extraordinary multienzyme activities to induce reactive oxygen species (ROS) storm formation, which can damage existing HSPs in cells. Through two-pronged strategy SGLT inhibitor and ROS storm, LIK066-loaded shows high efficiency comprehensive removal realize

Язык: Английский

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Ferroptosis Detection: From Approaches to Applications

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(35)

Опубликована: Фев. 25, 2023

Abstract Understanding the intricate molecular machinery that governs ferroptosis and leveraging this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, prognosis. Emerging approaches for in situ detection of major regulators biological events across cellular, tissue, living subjects provide a multiscale perspective studying ferroptosis. Furthermore, advanced applications integrate latest technologies hold tremendous promise research. In review, we first briefly summarize mechanisms key underlying Ferroptosis are then presented to delineate their design, action, applications. Special interest is placed on multifunctional platforms. Finally, discuss prospects challenges applications, with aim providing roadmap theranostic development broad range ferroptosis‐related diseases.

Язык: Английский

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Fe/Mn Bimetal-Doped ZIF-8-Coated Luminescent Nanoparticles with Up/Downconversion Dual-Mode Emission for Tumor Self-Enhanced NIR-II Imaging and Catalytic Therapy

ACS Nano, Год журнала: 2022, Номер 16(11), С. 18143 - 18156

Опубликована: Окт. 19, 2022

ZIF-8, as an important photoresponsive metal–organic framework (MOF), holds great promise in the field of cancer theranostics owing to its versatile physiochemical properties. However, photocatalytic anticancer application is still restricted because wide bandgap and specific response ultraviolet light. Herein, we developed lanthanide-doped nanoparticles (LDNPs) coated with Fe/Mn bimetal-doped ZIF-8 (LDNPs@Fe/Mn-ZIF-8) for second near-infrared (NIR-II) imaging-guided synergistic photodynamic/chemodynamic therapy (PDT/CDT). The LDNPs were synthesized by encapsulating optimal Yb3+/Ce3+-doped active shell on NaErF4:Tm core achieve dual-mode red upconversion (UC) NIR-II downconversion (DC) emission upon NIR laser irradiation. At doping concentration, UC DC intensities increased 30.2- 13.2-fold above those nanoparticles, which endowed LDNPs@Fe/Mn-ZIF-8 outstanding capability carry out UC-mediated PDT optical imaging. In addition, dual Fe2+/Mn2+ markedly decreased photosensitizer from 5.1 1.7 eV, expanding excitation threshold visible light region (∼650 nm), enabled Fe/Mn-ZIF-8 be efficiently excited photons photocatalytic-driven PDT. Furthermore, ions could responsively released tumor microenvironment through degradation Fe/Mn-ZIF-8, thereby producing hydroxyl radicals (·OH) Fenton/Fenton-like reactions realize CDT. Meanwhile, nanosystems self-enhanced imaging function, providing precise guidance CDT/PDT.

Язык: Английский

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Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy

Exploration, Год журнала: 2023, Номер 3(5)

Опубликована: Июнь 30, 2023

Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application

Язык: Английский

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Ferritin‐Hijacking Nanoparticles Spatiotemporally Directing Endogenous Ferroptosis for Synergistic Anticancer Therapy

Advanced Materials, Год журнала: 2022, Номер 34(51)

Опубликована: Окт. 10, 2022

Abstract Existing ferroptosis as an iron‐dependent form of regulated cell death primarily relies on importing exogenous iron. However, the excessive employment toxic materials may cause potential adverse effects human health. Herein, a ferritin‐hijacking nanoparticle (Ce6‐PEG‐HKN 15 ) is fabricated, by conjugating ferritin‐homing peptide HKN with photosensitizer chlorin e6 (Ce6) for endogenous without introducing Fenton‐reactive metals. Once internalized, designed Ce6‐PEG‐HKN NPs can specifically accumulate around ferritin. With laser irradiation, activated Ce6 in nanoparticles potently generates reactive oxygen species (ROS) surrounding Abundant ROS not only helps to destroy iron storage protein and activate but also directly kill tumor cells. In turn, released partially interacts intracellular excess H 2 O produce , thereby enhancing photodynamic therapy further amplifying oxidative stress. Overall, this work highlights possibility via spatiotemporally destroying ferritin, offering paradigm synergistic ferroptosis–photodynamic antitumor therapy.

Язык: Английский

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Overcoming Hypoxia‐Induced Ferroptosis Resistance via a¹⁹F/¹H‐MRI Traceable Core‐Shell Nanostructure

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(48)

Опубликована: Окт. 12, 2022

Abstract Lipid peroxides accumulation induced ferroptosis is an effective cell death pathway for cancer therapy. However, the hypoxic condition of tumor microenvironment significantly suppresses efficacy ferroptosis. Here, we design a novel nanoplatform to overcome hypoxia‐induced resistance. Specifically, synthesize kind perfluorocarbon (PFOB)@manganese oxide (MnOx) core‐shell nanoparticles (PM‐CS NPs). Owing good carrier O 2 as fuel, PM‐CS NPs can induce higher level ROS generation, lipid peroxidation and GSH depletion, well lower activity GPX4, compared with MnOx alone. Moreover, supplement relieve hypoxia break down storage intracellular droplets increase expression ACSL4 (a symbol sensitivity). Furthermore, upon stimulus or acidity, exhibit “turn on” 19 F‐MRI signal activatable T 1 /T ‐MRI contrast correlating release Mn. Finally, exert high inhibition rate based therapy via synergetic combination ‐mediated enhancement key pathways

Язык: Английский

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Double Hydrogen‐bonding Reinforced High‐Performance Supramolecular Hydrogel Thermocell for Self‐powered Sensing Remote‐Controlled by Light

Advanced Functional Materials, Год журнала: 2023, Номер 33(9)

Опубликована: Янв. 12, 2023

Abstract Non‐contact human‐machine interaction is the future trend for wearable technologies. This demand recently highlighted by pandemic of coronavirus disease (COVID‐19). Herein, an anti‐fatigue and highly conductive hydrogel thermocell with photo‐thermal conversion ability non‐contact self‐powering applications designed. Double hydrogen‐bonding enhanced supramolecular obtained N‐acryloyl glycinamide (NAGA) diacrylate capped Pluronic F68 (F68‐DA) via one‐step photo‐initiated polymerization. The can accommodate saturated electrolytes to fulfill triple function ionic crosslinking, heat‐to‐electricity conversion, light response thermocell. Eminently, stands out virtue its high seebeck coefficient (‐2.17 mV K −1 ) extraordinary toughness (Fatigue threshold ≈ 3120 J m −2 ). under control heating explored, a model “light‐remoted” sensor self‐powered sensing integrated performance remote‐controlled constructed. It believed that this study will pave way energy supply devices.

Язык: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Год журнала: 2023, Номер 32, С. 66 - 97

Опубликована: Сен. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Язык: Английский

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