Recent Advances in Functionalization of Aromatic C(sp²)—H Bonds Based on N-Nitroso Direction

Chinese Journal of Organic Chemistry, Год журнала: 2023, Номер 43(12), С. 4157 - 4157

Опубликована: Янв. 1, 2023

Язык: Английский

Palladium‐Catalyzed Ring‐Closing Aminoalkylative Amination of Unactivated Aminoenynes

Angewandte Chemie, Год журнала: 2022, Номер 135(3)

Опубликована: Ноя. 21, 2022

Abstract An efficient strategy for preventing the β‐hydride elimination of alkylpalladium species by ligation palladium with adjacent amino‐group was developed, which enabled a novel palladium‐catalyzed ring‐closing aminoalkylative amination unactivated aminoenynes. The reaction is amenable to aminals, as well aliphatic aldehydes secondary amines, provides straightforward access structurally diverse exocyclic allenic amines bearing 5 12‐membered N ‐heterocycles. With chiral phosphoramidite‐ligated complex catalyst, an enantioselective variant achieved up 93 % ee. Simultaneously, synthetic transformations products were also conducted afford unique spirodiamines including one pharmaceutically active molecule via axial‐to‐central chirality transfer.

Язык: Английский

Diastereoselective C–H Functionalizations

Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 138 - 179

Опубликована: Авг. 10, 2023

Язык: Английский