Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

Molecules, Год журнала: 2023, Номер 28(10), С. 4085 - 4085

Опубликована: Май 14, 2023

Energy transfer to ground state triplet molecular oxygen results in the generation of singlet (1O2), which has potent oxidizing ability. Irradiation light, notably ultraviolet A, a photosensitizing molecule 1O2, is thought play role causing skin damage and aging. It should also be noted that 1O2 dominant tumoricidal component generated during photodynamic therapy (PDT). While type II action generates not only but other reactive species, endoperoxides release pure upon mild exposure heat and, hence, are considered beneficial compounds for research purposes. Concerning target molecules, preferentially reacts with unsaturated fatty acids produce lipid peroxidation. Enzymes contain cysteine group at catalytic center vulnerable exposure. Guanine base nucleic susceptible oxidative modification, cells carrying DNA oxidized guanine units may experience mutations. Since produced various physiological reactions addition reactions, overcoming technical challenges related its detection methods used would allow potential functions biological systems better understood.

Язык: Английский

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Tumor Microenvironment Activated Photoacoustic-Fluorescence Bimodal Nanoprobe for Precise Chemo-immunotherapy and Immune Response Tracing of Glioblastoma

ACS Nano, Год журнала: 2023, Номер 17(20), С. 19753 - 19766

Опубликована: Окт. 9, 2023

Synergistic therapy strategy and prognostic monitoring of glioblastoma's immune response to treatment are crucial optimize patient care advance clinical outcomes. However, current systemic temozolomide (TMZ) chemotherapy imaging methods for in vivo tracing responses inadequate. Herein, we report an all-in-one theranostic nanoprobe (PEG/αCD25-Cy7/TMZ) precise real-time glioblastoma by photoacoustic-fluorescence imaging. The was loaded with TMZ targeted regulatory T lymphocyte optical dye αCD25-Cy7 encapsulated glutathione-responsive DSPE-SS-PEG2000. results showed that the efficiency lymphocytes is up 92.3%. activation PEG/αCD25-Cy7/TMZ glutathione enhanced delivery tumor microenvironment local monitored boundary Immunotherapy indoleamine 2,3-dioxygenase inhibitors after could promote immunological reduce infiltration, which improve survival rate. Photoacoustic has noninvasively depicted dynamic process on a micrometer scale, showing infiltration up-regulated would down-regulate IDO inhibitor treatment. This promising method precisely delivering long-term dynamically evaluate situ accurate chemo-immunotherapy.

Язык: Английский

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Hemicyanine-Based Type I Photosensitizers for Antihypoxic Activatable Photodynamic Therapy

ACS Materials Letters, Год журнала: 2023, Номер 5(11), С. 3058 - 3067

Опубликована: Окт. 20, 2023

Type I photosensitizers provide great potential for effective antihypoxia cancer treatment because of their low O2 reliance. To achieve tumor specificity, activatable type that can selectively respond to tumor-related stimuli and thereafter activate phototoxicity are urgently required, which however rare. We herein report a hemicyanine-based scaffold with photoreactions antihypoxic PDT against tumors. The common hemicyanine (Cy) endows minimized ROS generation, be nicely tuned boost production by introducing the halogens increase spin–orbit coupling (SOC) constant thus favor intersystem crossing (ISC) rate. optimized CyBr is further modified an probe (CyBrP) specifically unlock its fluoro-photoacoustic signals upon interaction alkaline phosphatase (ALP) overexpressed in By virtue high sensitivity selectivity toward ALP as well O2-dependence CyBrP allows precise phototheranostics tumors, leading effectively suppressed growth living mice. Therefore, this study presents facile halogen-substituted strategy construct serve universal scaffolds PDT.

Язык: Английский

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Recent progress in metal complexes functionalized nanomaterials for photodynamic therapy

Chemical Communications, Год журнала: 2023, Номер 59(46), С. 6956 - 6968

Опубликована: Янв. 1, 2023

The recent developments and applications of metal complexes functionalized nanomaterials for photodynamic cancer therapy are reviewed.

Язык: Английский

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Photonic control of image-guided ferroptosis cancer nanomedicine

Coordination Chemistry Reviews, Год журнала: 2023, Номер 500, С. 215532 - 215532

Опубликована: Ноя. 10, 2023

Язык: Английский

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