The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(14), С. 10223 - 10233
Опубликована: Июнь 28, 2024
A
photo-induced
cascade
sulfone
alkylation/cyclization
of
2-isocyanoaryl
thioethers
is
explored.
This
visible-light-triggered
reaction
not
only
occurs
under
extremely
mild
conditions
but
also
does
require
the
presence
a
photosensitizer.
The
photocatalytic
process
triggered
by
photochemical
activity
in
situ-generated
electron
donor–acceptor
complexes,
arising
from
association
and
α-iodosulfones.
radical
pathway
was
confirmed
UV–vis
spectroscopy,
trapping,
Job's
plot,
on/off
irradiation
experiments.
Chemical Communications,
Год журнала:
2024,
Номер
60(18), С. 2556 - 2559
Опубликована: Янв. 1, 2024
3-(2-Isocyanophenyl)quinazolin-4(3
H
)-ones
were
designed
and
synthesized
as
new
building
units
for
the
construction
of
novel
quinoxalino[2,1-
b
]quinazolinones
under
mild,
photocatalytic
metal-free
conditions.
Chemical Communications,
Год журнала:
2024,
Номер
60(35), С. 4687 - 4690
Опубликована: Янв. 1, 2024
A
visible-light-induced
carbophosphorylation/cyclization
of
N
-homoallyl
and
-allyl
aldehyde
hydrazones
with
phosphine
oxides
was
developed
to
obtain
phosphorylated
tetrahydropyridazines
dihydropyrazoles.
Organic Letters,
Год журнала:
2024,
Номер
26(32), С. 6809 - 6813
Опубликована: Авг. 5, 2024
Represented
herein
is
the
first
1,3-difunctionalization
of
alkenes
via
photocatalysis.
A
single
cobaloxime
used
to
carry
out
two
catalytic
cycles
in
which
not
only
as
a
photocatalyst
initiate
reaction
but
also
metal
catalyst
for
β-H
elimination
process.
Electron-deficient
alkenes,
electron-rich
and
unactivated
could
be
directly
converted
1,3-bisphosphorylated
products,
even
unsymmetric
with
H
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(7)
Опубликована: Дек. 13, 2022
A
new
way
to
form
fluorenones
via
the
direct
excitation
of
substrates
instead
photocatalyst
activate
C(sp2
)-H
bond
under
redox-neutral
condition
is
reported.
Our
design
relies
on
photoexcited
aromatic
aldehyde
intermediates
that
can
be
intercepted
by
cobaloxime
catalyst
through
single
electron
transfer
for
following
β-H
elimination.
The
generation
acyl
radical
and
successful
interception
a
metal
avoid
use
stoichiometric
external
oxidants,
affording
series
highly
substituted
fluorenones,
including
six-membered
ketones,
such
as
xanthone
thioxanthone
derivatives
in
good
excellent
yields,
with
hydrogen
only
byproduct.
This
catalytic
system
features
readily
available
catalyst,
mild
reaction
conditions
broad
substrate
scope,
which
sunlight
scale-up
experiments
continuous-flow
approach
make
methodology
sustainable
amenable
potentially
operational
procedures.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
present
two
protocols
for
the
efficient
synthesis
of
substituted
1-naphthols.
DFT
calculations
and
verification
experiments
elucidate
mechanism.
Scale-up
product
conversion
confirm
reaction's
practical
potential.
Radical-initiated
functionalization
of
bicyclo[1.1.0]butanes
(BCBs)
is
a
straightforward
approach
to
accessing
diverse
cyclobutane
derivatives.
However,
selective
C(sp3)–H
at
the
C2
position
BCBs
remains
scarce.
Herein,
mild
protocol
for
hydrogen-evolution
phosphorylation
with
enabled
by
photoinduced
cobaloxime
catalysis
was
realized
in
regio-
and
diastereoselective
manner.
This
oxidant-
additional
photocatalyst-free
method
wide
range
diarylphosphine
oxides.
The
mechanism
studied
via
control
experiments
DFT
calculation.
Moreover,
efficiency
this
highlighted
synthesis
high-value,
structurally
complex
molecules.
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Comprehensive
Summary
Herein,
it
is
reported
that
the
aryl
radicals
derived
from
thianthrenium
salts
are
used
as
coupling
partner
in
arylation
reactions
of
isocyanides,
simultaneously
initiators
for
formation
alkyl
and
phosphoryl
ethers
diarylphosphine
oxides.
This
cascade
cyclization
reaction
leads
to
diverse
arylated,
alkylated
phosphorylated
heteroaromatic
compounds.
Notably,
this
transformation
can
be
achieved
without
aid
metals
or
photocatalysts,
exhibiting
a
wide
substrate
applicability
operational
simplicity.
Mechanistic
studies
suggest
involvement
radical
processes
electron
donor‐acceptor
(EDA)
complexes
transformation.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
reported
the
first
example
of
visible-light-induced
radical
cascade
cyclization
2-isocyanobiaryls
via
1,5-HAT,
which
is
characterized
by
broad
substrate
scope,
excellent
functional
group
compatibility
and
no
requirement
any
metals
base.
