Macromolecules,
Год журнала:
2024,
Номер
57(8), С. 3824 - 3830
Опубликована: Апрель 10, 2024
Due
to
the
combination
of
flexibility
and
mobility,
polycatenanes
have
potential
in
constructing
various
functional
materials.
To
date,
most
previous
works
reported
poly[2]catenanes
with
a
degree
polymerization
(DP)
around
20.
However,
it
remains
significant
challenge
synthesize
higher
DP
value.
Hydroxyl–yne
click
polymerization,
bearing
merits
obtaining
polymers
high
values,
short
reaction
time,
mild
condition,
is
promising
be
employed
preparing
values.
Herein,
strategy
using
hydroxyl–yne
chemistry
fabricate
was
proposed.
With
two
hydroxyl
groups
on
both
rings,
[2]catenane
monomer
M1
prepared.
Meanwhile,
hexaethylene
glycol
alkyne
functionalized
as
M2.
bicyclo[2.2.2]-1,4-diazaoctane
(DABCO)
catalyzing,
M2
reacted
via
at
room
temperature.
The
resultant
poly[2]catenane
reached
up
36.
In
addition,
tetraphenylethylene
(TPE)
modified
propiolic
acid
obtain
M3.
Then,
poly([2]catenane-alt-TPE)
aggregation-induced
emission
(AIE)
properties
obtained
between
M3
well.
How
to
modulate
the
molecular
structure
finely
manipulate
sensing
performance
is
of
great
significance
for
propelling
oriented
design
optical
probe.
Here,
by
taking
detection
toward
amphetamine
(AMP)
as
a
model,
structural
regulation
strategy
D-π-A
probe
was
proposed
reaction
activity
and
response.
The
optimal
screened
out
from
series
molecules
with
an
electrophilic
site
owing
its
faster
response
more
remarkable
emission
shift,
well
desirable
specificity.
In
particular,
it
found
that
reactivity
induced
two
trade-off
effects.
First,
kinetically
expressed
time
greatly
affects
sensitivity
(emission
shift),
second,
thermodynamically
determines
Upon
fine
modulation,
in
solid
state
integrated
portable
chip
demonstrated
fast
visualized
analysis
AMP
complicated
scenarios.
Overall,
structure–performance
correlation
mediation
on
effect
would
provide
in-depth
insight
sensor
performance.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(35)
Опубликована: Май 8, 2023
Abstract
Helicobacter
pylori
(
H.
)
is
listed
as
a
definite
carcinogen
and
clinical
triple
therapy
less
satisfactory
because
colonizes
beneath
the
gastric
mucous
layer
easily
forms
biofilm.
More
importantly,
frequent
excessive
use
of
antibiotics
causes
disorder
gut
microbiota
due
to
lack
targeting
.
Here,
kind
protonated
charge
reversal
metal
based
nanodrugs
(MNDs)—ZnO‐Ag‐mercaptoacetamide@chitosan
for
eradication
treatment
without
affecting
beneficial
prepared.
In
infected
mouse
model,
MNDs
actively
target
submucosa
colonized
owing
penetrability
protonation
effect,
further
eradicate
its
biofilm
by
producing
ions
reactive
oxygen
species.
Transcriptomic
analysis
shows
that
there
are
no
obvious
side
effects
intestinal
microorganisms
during
treatment.
Besides,
it
found
great
potential
remove
inflammation
along
with
blocking
inflammatory
pathways
reduction
virulence
factors,
which
related
infiltration
CD4
+
T
cells
clear
Macromolecules,
Год журнала:
2024,
Номер
57(8), С. 3824 - 3830
Опубликована: Апрель 10, 2024
Due
to
the
combination
of
flexibility
and
mobility,
polycatenanes
have
potential
in
constructing
various
functional
materials.
To
date,
most
previous
works
reported
poly[2]catenanes
with
a
degree
polymerization
(DP)
around
20.
However,
it
remains
significant
challenge
synthesize
higher
DP
value.
Hydroxyl–yne
click
polymerization,
bearing
merits
obtaining
polymers
high
values,
short
reaction
time,
mild
condition,
is
promising
be
employed
preparing
values.
Herein,
strategy
using
hydroxyl–yne
chemistry
fabricate
was
proposed.
With
two
hydroxyl
groups
on
both
rings,
[2]catenane
monomer
M1
prepared.
Meanwhile,
hexaethylene
glycol
alkyne
functionalized
as
M2.
bicyclo[2.2.2]-1,4-diazaoctane
(DABCO)
catalyzing,
M2
reacted
via
at
room
temperature.
The
resultant
poly[2]catenane
reached
up
36.
In
addition,
tetraphenylethylene
(TPE)
modified
propiolic
acid
obtain
M3.
Then,
poly([2]catenane-alt-TPE)
aggregation-induced
emission
(AIE)
properties
obtained
between
M3
well.
