α‐Difluoroalkylation of Benzyl Amines with Trifluoromethylarenes

Angewandte Chemie, Год журнала: 2023, Номер 135(40)

Опубликована: Авг. 19, 2023

Abstract An α‐difluoroalkylation of benzyl amines with trifluoromethylarenes is disclosed herein. This protocol characterized by its operational simplicity, excellent chemoselectivity and broad scope—even advanced synthetic intermediates—, thus offering a new entry point to medicinally‐relevant α‐difluoroalkylated from simple, yet readily accessible, precursors.

Язык: Английский

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Synthesis of 2,2′-Bipyridines via Dehydrogenative Dimerization of Pyridines Using Sodium Dispersion

Synlett, Год журнала: 2023, Номер 35(04), С. 459 - 463

Опубликована: Март 6, 2023

Abstract 2,2′-Bipyridine derivatives were synthesized by dehydrogenative dimerization of nonactivated pyridines using sodium dispersion. The reaction features operational simplicity, mild conditions, and the use earth abundant nontoxic as sole metal source. Importantly, transition metals are not required, which is beneficial in fields materials science drug synthesis, where contamination may cause significant problems.

Язык: Английский

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Structural and Synthetic Insights on Oxidative Homocouplings of Alkynes Mediated by Alkali‐Metal Manganates

Chemistry - A European Journal, Год журнала: 2023, Номер 29(33)

Опубликована: Март 17, 2023

Exploiting bimetallic cooperation alkali-metal manganate (II) complexes can efficiently promote oxidative homocoupling of terminal alkynes furnishing an array conjugated 1,3-diynes. The influence the on these C-C bond forming processes has been studied by preparing and structurally characterizing tetra(alkyl) manganates [(TMEDA)2 Na2 Mn(CH2 SiMe3 )4 ] [(PMDETA)2 K2 ]. Reactivity studies using phenylacetylene as a model substrate have revealed that for to take place initial metalation alkyne is required. In this regard, lack basicity neutral )2 precludes formation diyne. Contrastingly, behave polybasic reagents, being able easily deprotonate yielding [{(THF)4 Mn(C≡CPh)4 }∞ [(THF)4 Li2 Controlled exposure dry air confirmed their intermediary in 1,4-diphenyl-1,3-butadiyne excellent yields. While Na/Mn(II) partnership proved be most efficient stoichiometric transformations, under catalytic regimes, combination MC≡CAr (M= Li, Na) MnCl2 (6 mol %) only works lithium, likely due degradation alkynylsodiums aerobic reaction conditions.

Язык: Английский

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Challenges in the computational modelling of bimetallic C–H activation processes

Advances in organometallic chemistry, Год журнала: 2024, Номер unknown, С. 329 - 348

Опубликована: Янв. 1, 2024

Язык: Английский

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