Synlett,
Год журнала:
2022,
Номер
34(04), С. 293 - 300
Опубликована: Ноя. 20, 2022
Abstract
The
reassembly
of
unsaturated
C–C
bonds
has
attracted
widespread
attention
from
synthetic
chemists
due
to
its
advantages
unique
reactivity,
easy
handling,
and
high
atom
step
economies.
We
recently
explored
a
cutting/insertion
cascade
as
means
introducing
new
C1
source
constructing
functionalized
1,4-keto
aldehyde
2H-furan
derivatives
through
cyclopropanation
enamines
with
various
carbene
precursors
subsequent
ring-opening
reactions
in
situ.
Aminocyclopropanes
are
believed
be
involved
key
intermediates
these
transformations.
This
Synpacts
article
outlines
our
recent
contributions
this
increasingly
important
research
area.
1
Introduction
2
Cleavage
Enamine
C=C
Double
Bonds
Hydrolysis
1,4-Keto
Aldehydes
3
Cyclization
2H-Furans
4
Ynone/Ynoate
C≡C
Triple
5
Conclusion
Angewandte Chemie,
Год журнала:
2023,
Номер
135(41)
Опубликована: Авг. 26, 2023
Abstract
Nitroaromatic
compounds
represent
one
of
the
essential
classes
molecules
that
are
widely
used
as
feedstock
for
synthesis
intermediates,
preparation
nitro‐derived
pharmaceuticals,
agrochemicals,
and
materials
on
both
laboratory
industrial
scales.
We
herein
disclose
efficient,
mild,
catalytic
ipso
‐nitration
organotrimethylsilanes,
enabled
by
an
electrophilic
N
‐nitrosaccharin
reagent
allows
chemoselective
nitration
under
mild
reaction
conditions,
while
exhibiting
remarkable
substrate
generality
functional
group
compatibility.
Additionally,
conditions
proved
to
be
orthogonal
other
common
functionalities,
allowing
programming
molecular
complexity
via
successive
transformations
or
late‐stage
nitration.
Detailed
mechanistic
investigation
experimental
computational
approaches
strongly
supported
a
classical
aromatic
substitution
(S
E
Ar)
mechanism,
which
was
found
proceed
through
highly
ordered
transition
state.
Nanoscale,
Год журнала:
2023,
Номер
15(48), С. 19493 - 19498
Опубликована: Янв. 1, 2023
An
iron-incorporated
Zn-MOF
catalyst
Zn-bpydc·Fe
was
fabricated
for
the
oxidative
cleavage
of
trans-anethole
to
p-anisaldehyde
under
facile
conditions,
1
atm
O2.
The
Fe
coordinated
bipyridine
serves
as
catalytically
active
center
inside
structural
skeleton
Zn-MOFs.
This
work
affords
a
new
avenue
mild
oxidation
olefins.
Synlett,
Год журнала:
2022,
Номер
34(04), С. 293 - 300
Опубликована: Ноя. 20, 2022
Abstract
The
reassembly
of
unsaturated
C–C
bonds
has
attracted
widespread
attention
from
synthetic
chemists
due
to
its
advantages
unique
reactivity,
easy
handling,
and
high
atom
step
economies.
We
recently
explored
a
cutting/insertion
cascade
as
means
introducing
new
C1
source
constructing
functionalized
1,4-keto
aldehyde
2H-furan
derivatives
through
cyclopropanation
enamines
with
various
carbene
precursors
subsequent
ring-opening
reactions
in
situ.
Aminocyclopropanes
are
believed
be
involved
key
intermediates
these
transformations.
This
Synpacts
article
outlines
our
recent
contributions
this
increasingly
important
research
area.
1
Introduction
2
Cleavage
Enamine
C=C
Double
Bonds
Hydrolysis
1,4-Keto
Aldehydes
3
Cyclization
2H-Furans
4
Ynone/Ynoate
C≡C
Triple
5
Conclusion
