Analytical Chemistry,
Год журнала:
2024,
Номер
96(23), С. 9503 - 9511
Опубликована: Май 23, 2024
In
this
work,
a
micron-sized
flower-like
metal–organic
frameworks
(MOFs)-based
boronate-affinity
sandwich-type
immunoassay
was
fabricated
for
the
dual-mode
glycoprotein
assay.
For
proof
of
concept,
MOFs
were
synthesized
from
transition
Cu
nodes
and
tetrakis
(4-carboxyphenyl)
porphyrin
(TCPP)
ligands
by
spontaneous
standing
assembly.
addition,
specificity
toward
involved
antigen
recognition
as
well
covalent
bonding
via
boronate-glycan
affinity,
immediate
signal
responses
initiated
textural
decomposition
MOFs.
Intriguingly,
nodes,
which
valence
state
is
dominant
CuI
species,
can
endow
Fenton-like
catalytic
reaction
fluorogenic
substrate
generating
fluorescence
signals.
benefits,
TCPP
ligands,
in
each
molecule
has
four
guest
donors,
provide
multiple
valences
assembly
cyclodextrin-capped
gold
nanoparticles
host–guest
interaction
colorimetry
output.
Albeit
important,
scaling
micrometer
patterns
carrying
numerous
also
function
amplifying
units,
signifying
output
signal.
The
detection
limit
assay
reach
10.5
nM
mode
18.7
mode,
respectively.
Furthermore,
merits
harvesting
different
generators
multimodal
readout
allow
mutual
verification
make
analytical
results
more
reliable.
Collectively,
our
proposed
may
offer
new
idea
combining
inherent
dual
generators,
emphasize
accurate
capability
Chem & Bio Engineering,
Год журнала:
2024,
Номер
1(2), С. 99 - 112
Опубликована: Фев. 8, 2024
Enzymes,
as
highly
efficient
biocatalysts,
excel
in
catalyzing
diverse
reactions
with
exceptional
activity
and
selective
properties
under
mild
conditions.
Nonetheless,
their
broad
applications
are
hindered
by
inherent
fragility,
including
low
thermal
stability,
limited
pH
tolerance,
sensitivity
to
organic
solvents
denaturants.
Encapsulating
enzymes
within
metal–organic
frameworks
(MOFs)
can
protect
them
from
denaturation
these
harsh
environments.
However,
this
often
leads
a
compromised
enzyme
activity.
In
recent
years,
extensive
research
efforts
have
been
dedicated
enhancing
enzymatic
MOFs,
leading
the
development
of
new
enzyme–MOF
composites
that
not
only
preserve
catalytic
potential
but
also
outperform
free
counterparts.
This
Review
provides
comprehensive
review
on
developments
specific
emphasis
enhanced
compared
enzymes.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(22)
Опубликована: Фев. 4, 2024
Abstract
Manipulating
the
electronic
structure
and
coordination
configuration
of
heterogeneous
electrocatalyst
is
an
advantageous
strategy
to
motivate
intrinsic
activity
but
remains
challenging.
Herein,
guided
by
theoretical
mechanism
d‐band
center
valence‐bond
theory,
high‐valence
metal‐modulated
nickel‐vanadium
layered
double
hydroxides
(M‐NiV
LDH,
M
=
Zr,
Mo)
with
interfacial
oxygen
bridge
bonding
are
rationally
designed
fabricated,
affording
a
3D
vertically
staggered
porous
nanosheets
array
network.
Benefitting
from
abundant
unfilled
antibonding
orbitals
induced
optimized
Zr
d‐orbital
O
p‐orbital
hybridization,
introduction
site
beneficial
accelerate
charge
transfer
kinetics
optimize
deprotonation
OH*
as
well
lower
O*
→
OOH*
free
energy.
As
result,
as‐prepared
Zr‐NiV
LDH
exhibits
promising
evolution
reaction
performance
low
overpotential
favorable
long‐term
stability.
This
work
provides
valuable
insights
into
design
electrocatalysts
for
regulation
improvement.
Chemical Science,
Год журнала:
2024,
Номер
15(35), С. 14202 - 14208
Опубликована: Янв. 1, 2024
A
green
MOF
phosphor
can
maintain
84%
of
its
initial
emission
intensity
after
being
heated
to
150
°C,
exceeding
several
commercial
inorganic
phosphors.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 24, 2025
Two
or
more
catalysts
conducting
multistep
reactions
in
the
same
reactor,
concurrent
tandem
catalysis,
could
enable
(bio)pharmaceutical
and
fine
chemical
manufacturing
to
become
much
sustainable.
Herein
we
report
that
co-immobilization
of
metal
nanoparticles
a
biocatalytic
system
within
synthetic
covalent
organic
framework
capsule,
COFcap-2,
functions
like
an
artificial
cell
that,
whereas
are
trapped
300-400
nm
cavities,
substrates/products
can
ingress/egress
through
ca.
2
windows.
The
COFcap-2
reactor
is
first
coated
onto
electrode
surface
then
used
prepare
eleven
homochiral
amines
using
dinitrogen
as
feedstock.
amines,
including
drug
product
intermediates
active
pharmaceutical
ingredient,
prepared
>99%
enantiomeric
excess
under
ambient
conditions
water.
Importantly,
recycled
15
times
with
retention
performance,
addressing
relative
instability
poor
recyclability
enzymes
has
hindered
their
broad
implementation
for
energy-efficient,
low
waste
production
chemicals
(bio)pharmaceuticals.
Concurrent
two
would
be
beneficial
manufacturing.
Here,
authors
multienzyme
employ
it
Crystal Growth & Design,
Год журнала:
2023,
Номер
23(4), С. 2882 - 2892
Опубликована: Фев. 27, 2023
Due
to
the
excellent
catalytic
performance
of
Co-MOFs
and
Ln-MOFs
on
chemical
fixation
CO2,
self-assembly
microporous
heterometallic
compounds
with
aid
designed
functional
ligands
is
carried
out
in
our
group.
Herein,
solvothermal
Co2+,
Yb3+,
2,6-bis(2,4-dicarboxylphenyl)-4-(4-carboxylphenyl)pyridine
(H5BDCP)
generated
a
rarely
reported
{CoYb}n-chain-based
framework
{[CoYb(BDCP)(H2O)]·3DMF·3H2O}n
(NUC-70)
quasi-nanoporous
channels
(aperture
ca.
11.4
Å)
shaped
by
six
rows
{CoYb(CO2)5(H2O)}n
nodes.
To
best
knowledge,
this
rare
3d-4f
chain
staggered
arrangement
Co2+
Yb3+.
After
removing
associated
water
molecules,
NUC-70a
possesses
characteristics
large
specific
surface
area,
unsaturated
open
metal
sites
Yb3+
as
Lewis
acid
sites,
high
heat/water-resistant
physicochemical
properties.
Catalytic
experiments
showed
that
possessed
activity
cycloaddition
reactions
epoxides
CO2
under
mild
conditions.
Furthermore,
performed
confirmed
Knoevenagel
condensation
aldehydes
malononitrile
could
be
efficiently
catalyzed
NUC-70a.
This
work
illustrates
characteristic
ligand
design
plays
key
role
MOFs
functions.
ACS Central Science,
Год журнала:
2024,
Номер
10(2), С. 358 - 366
Опубликована: Янв. 18, 2024
Encapsulating
enzymes
within
metal–organic
frameworks
has
enhanced
their
structural
stability
and
interface
tunability
for
catalysis.
However,
the
small
apertures
of
restrict
effectiveness
to
organic
molecules.
Herein,
we
present
a
green
strategy
directed
by
visible
linker
micelles
aqueous
synthesis
MAF-6
that
enables
catalytic
asymmetric
chiral
Due
large
pore
aperture
(7.6
Å),
double
size
benchmark
ZIF-8
(3.4
allows
encapsulated
enzyme
BCL
access
larger
substrates
do
so
faster.
Through
optimization
surfactants'
effect
during
synthesis,
BCL@MAF-6-SDS
(SDS
=
sodium
dodecyl
sulfate)
displayed
efficiency
(Kcat/Km)
was
420
times
greater
than
BCL@ZIF-8.
This
biocomposite
efficiently
catalyzed
drug
precursor
molecules
with
94–99%
enantioselectivity
nearly
quantitative
yields.
These
findings
represent
deeper
understanding
de
novo
synthetic
encapsulation
in
MOFs,
thereby
unfolding
great
potential
enzyme@MAF
catalysts
organics
pharmaceuticals.
Nano Letters,
Год журнала:
2024,
Номер
24(4), С. 1341 - 1350
Опубликована: Янв. 22, 2024
In
situ
drug
synthesis
using
the
copper-catalyzed
azide–alkyne
cycloaddition
(CuAAC)
reaction
has
attracted
considerable
attention
in
tumor
therapy
because
of
its
satisfactory
effectiveness
and
reduced
side-effects.
However,
exogenous
addition
copper
catalysts
can
cause
cytotoxicity
hampered
biomedical
applications
vivo.
Here,
we
design
synthesize
a
metal–organic
framework
(MOF)
to
mimic
chaperone,
which
selectively
modulate
trafficking
for
bioorthogonal
with
no
need
catalysts.
Like
chaperones,
prepared
ZIF-8
chaperone
mimics
specifically
bind
ions
through
formation
coordination
bonds.
Moreover,
is
unloaded
under
acidic
environment
due
dissipation
interactions
between
metal
ligands.
this
way,
cancer
cell-targeted
transport
into
cells.
Regulation
intracellular
may
inspire
constructing
catalysis
system
live
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Enzymes
are
promising
biocatalysts
due
to
their
high
efficiency,
mild
conditions,
specificity,
nontoxicity,
and
environmental
friendliness.
However,
the
enzyme
suffers
from
poor
stability
reusability.
Enzyme
immobilization
is
a
commonly
used
technology
enhance
its
In
this
study,
cellulose
nanocrystal
(CNC)
was
chosen
as
carrier
sustainability,
specific
surface
area,
biocompatibility,
water
dispersibility,
excellent
Pickering
emulsifying
ability.
Lipase
immobilized
on
polydopamine-coated
CNC
(PC),
obtained
lipase-immobilized
PC
(LPC)
displayed
significantly
enhanced
higher
activity
in
harsh
conditions
compared
free
lipase.
LPC
possessed
partial
wettability
with
both
oil
phases
lower
absolute
value
of
zeta
potential
than
CNC,
endowing
it
better
ability
CNC.
fixed
at
oil–water
interface
emulsion
by
ultrasonication,
resulting
droplets
were
employed
microreactors
for
ester
hydrolysis
synthesis
via
biocatalysis.
catalysis
lipase
traditional
biphasic
system
increased
contact
area
between
substrate,
reduced
diffusion
distance
activation
effect.
Moreover,
could
be
facilely
recycled
centrifugation,
still
retains
activity.
This
study
proposed
facile
sustainable
method
reusability
achieved
