Doping‐Engineered Piezoelectric Ultrathin Nanosheets for Synergistically Piezo‐Chemocatalytic Antitumor and Antibacterial Therapies Against Cutaneous Melanoma

Small, Год журнала: 2024, Номер unknown

Опубликована: Июнь 7, 2024

Abstract The post‐surgical melanoma recurrence and wound infections have persistently troubled clinical management. Piezocatalytic therapy features high efficiency in generating reactive oxygen species (ROS) for tumor therapy, but it faces limitations piezoelectricity redox‐active site availability. Herein, Fe‐doped ultrathin Bi 4 Ti 3 O 12 nanosheets (designated as Fe‐UBTO NSs) with synergistically piezo‐chemocatalytic activity are engineered antitumor antibacterial treatment against cutaneous melanoma. doping‐engineered strategy induces vacancies lattice distortions NSs, which narrows bandgap to enhance piezocatalytic 1 2 H generation by improving the electron‐hole pairs separation, hindering their recombination, increasing adsorption. Moreover, Fe doping establishes a system, piezocatalysis enables self‐supply of expedites electron transfer Fenton reactions, inducing increased ·OH production. Besides, atomic‐level thickness expanded surface area sensitivity ultrasound stimuli expose more sites, augmenting efficiency, ultimately leading abundant ROS generation. Fe‐UBTO‐mediated causes intracellular oxidative stress, triggering apoptosis excessive autophagy cells. this accelerates healing facilitating sterilization, angiogenesis, collagen deposition. This work provides distinct options develop augmented postoperative management

Язык: Английский

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Artificial Bacteriophages for Treating Oral Infectious Disease via Localized Bacterial Capture and Enhanced Catalytic Sterilization

Advanced Science, Год журнала: 2024, Номер 11(41)

Опубликована: Авг. 19, 2024

Abstract With the rapid emergence of antibiotic‐resistant pathogens, nanomaterial‐assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating level reactive oxygen species including hydroxyl radical (·OH). Although promising, ultra‐short lifetime and limited diffusion distance ·OH severely limit their practical antibacterial usage. Herein, rational design preparation novel virus‐like copper silicate hollow spheres (CSHSs) are reported, as applications robust artificial bacteriophages for localized bacterial capture enhanced in treatment oral infectious diseases. During whole process killing, CSHSs can efficiently via shortening between CSHSs, produce massive around bacteria, further iinducing admirable effect inhibition. By using mucosal infection periodontitis typical diseases, it is easily found that populations lesions animals after fall sharply, well‐developed nanosystem decrease inflammatory reaction promote hard or soft tissue repair. Together, high Fenton‐like activity, strong affinity, excellent overall safety nanoplatform promise its great therapeutic potential disinfection.

Язык: Английский

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Coordination Engineering in Fe‐Mn Dual‐Atom Nanozyme: Yielding ROS Storm to Efficiently Promote Wound Healing

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Multidrug‐resistant bacterial infections have become a global public health issue. To solve this dilemma, single‐atom nanozymes been used as versatile antibiotics. However, the efficacy of individual nanozyme is hindered by their limited catalytic activity and antibacterial effect. Herein, novel N 3 ‐Fe 1 ‐Mn ‐N 2 S (Fe/Mn‐SNC), with neighboring Mn Fe dual pairs decorated on yolk‐shell‐like carbon skeleton, constructed through partial modulation Fe‐Mn site coordination sulfur atoms. The developed Fe/Mn‐SNC possesses superior multienzyme‐like cascade activities (oxidase‐, superoxide‐, peroxidase‐like activities). It catalyzes conversion O into ·− its oxidase‐like activity, which then decomposed H superoxide‐like enzyme properties. Ultimately, ·OH generated under influence activity. This process effectively kills bacteria without addition , contributing to overcoming resistance issues. Density functional theory calculations indicate that direct coordinated atom enhances dual‐atomic provides an additional active for enhancement superoxidase‐ activities. Fe/Mn‐SNC, high effect biosafety, showing wide potential applications in medical technology consumer care. work opens new avenue designing multifunctional applications.

Язык: Английский

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Metal-based nanomedicines and their immunoregulatory effects

Chinese Science Bulletin (Chinese Version), Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Hybrid nickel-molybdenum bimetallic sulfide nanozymes for antibacterial and antibiofouling applications

Advanced Composites and Hybrid Materials, Год журнала: 2023, Номер 6(4)

Опубликована: Июль 19, 2023

Язык: Английский

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