Synlett,
Год журнала:
2023,
Номер
34(12), С. 1385 - 1390
Опубликована: Фев. 21, 2023
Abstract
Barbier-type
reactions
are
a
classic
group
of
for
carbon–carbon
bond
formation;
however,
their
common
use
stoichiometric
metals
restricts
widespread
application.
Considering
the
ready
availability
and
diversity
cyclic
amines,
we
report
visible-light
photocatalytic
reaction
aziridines
azetidines
with
nonactivated
aldehydes.
A
series
important
γ-
δ-amino
alcohols
were
synthesized
in
presence
amines
as
electron
donors.
Moreover,
this
transition-metal-free
protocol
displays
mild
conditions,
broad
functional-group
tolerance,
wide
substrate
scope.
Mechanistic
investigations
indicated
that
carbon
radicals
carbanions
might
be
generated
key
intermediates.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
summarizes
recent
advancements
in
radical-mediated
deaminative
transformations,
focusing
on
the
mechanisms,
substrate
compatibility,
and
emerging
applications
synthetic
organic
chemistry.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(22), С. 6340 - 6346
Опубликована: Янв. 1, 2024
We
developed
the
first
transition-metal-catalyzed,
regiodivergent
sulfonylation
of
aziridines,
enabling
efficient
synthesis
diverse
β-amino
sulfones
under
mild
conditions
with
broad
substrate
compatibility
and
high
regioselectivity.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Cleavage
of
inert
C-N
bonds
in
unstrained
azacycles
such
as
pyrrolidine
remains
a
formidable
challenge
synthetic
chemistry.
To
address
this,
we
introduce
an
effective
strategy
for
the
reductive
cleavage
bond
Synlett,
Год журнала:
2023,
Номер
34(12), С. 1385 - 1390
Опубликована: Фев. 21, 2023
Abstract
Barbier-type
reactions
are
a
classic
group
of
for
carbon–carbon
bond
formation;
however,
their
common
use
stoichiometric
metals
restricts
widespread
application.
Considering
the
ready
availability
and
diversity
cyclic
amines,
we
report
visible-light
photocatalytic
reaction
aziridines
azetidines
with
nonactivated
aldehydes.
A
series
important
γ-
δ-amino
alcohols
were
synthesized
in
presence
amines
as
electron
donors.
Moreover,
this
transition-metal-free
protocol
displays
mild
conditions,
broad
functional-group
tolerance,
wide
substrate
scope.
Mechanistic
investigations
indicated
that
carbon
radicals
carbanions
might
be
generated
key
intermediates.
