Ni-Catalyzed Cyanation of (Hetero)aryl Halides with Acetonitrile as Cyano Source

ACS Catalysis, Год журнала: 2024, Номер 14(4), С. 2350 - 2357

Опубликована: Янв. 31, 2024

We present a highly efficient method for cyanating challenging substrates with specific focus on aryl fluorides. This innovative methodology has been successfully expanded to encompass diverse array of halides, underscoring its versatility and broad applicability. The nickel-catalyzed protocol utilizes acetonitrile under mild temperature conditions, providing clean safe alternative cyanation. Notably, it employs nonhazardous, nongaseous, metal-free cyanide source demonstrates wide substrate scope, accommodating chlorides, fluorides, bromides, iodides. reaction is particularly effective acetonitrile. catalytic cyanation process serves as valuable route synthesizing pharmaceuticals such letrozole, citalopram, other NNRTI drugs. Mechanistically, we propose that cycle involving zerovalent nickel divalent more plausible this reaction.

Язык: Английский

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Strategy To Enhance Interfacial Properties: Preparation of Porous Polytetrafluoroethylene Fibers and the Adsorption of Initiators/Curing Agents

Langmuir, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Polytetrafluoroethylene (PTFE) fibers exhibit high inertness and demonstrate limited interfacial bonding capabilities with other materials. To overcome this limitation, PTFE@ZnO were developed by depositing the porous ZnO layer onto PTFE via a hydrothermal reaction, adsorbed curing agents or initiators. The shear strength (ILSS) of composites demonstrated significant improvement, particularly in case containing PTFE/initiator fibers, where ILSS increased 104.8% compared to alone (from 8.3 17.0 MPa). digital image correlation (DIC) method revealed more uniform stress distribution modified fiber at point fracture. Additionally, nanoscratch tests indicated enhancement between resin. structures facilitated mechanical interlocking Furthermore, presence an initiator/curing agent within structure served as initiation site for free radical polymerization vinyl ester resin 901, thereby enhancing novel strategy presents general viable approach extensive modification focusing on achieving exceptional properties.

Язык: Английский

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The roles of Lewis acids in nickel catalysis

Royal Society of Chemistry eBooks, Год журнала: 2024, Номер unknown, С. 73 - 92

Опубликована: Дек. 6, 2024

Due to the global demand for more sustainable chemical production, Ni-catalysis has attracted significant attention, leading discovery of a plethora powerful synthetic transformations. However, mechanisms by which these transformations occur are still shrouded in mystery and poorly understood. In particular, roles that Lewis acids can undertake often complicate mechanistic picture. Herein, we discuss several examples demonstrate beneficial, detrimental, effects have Ni-catalysis.

Язык: Английский

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PETプローブ開発を指向した分子設計と合成戦略

Journal of Synthetic Organic Chemistry Japan, Год журнала: 2024, Номер 82(5), С. 433 - 449

Опубликована: Май 1, 2024

The positron emission tomography (PET) is one of the imaging technologies that allows for visualization behavior a bioactive compound labeled with nuclide, generally called PET probe. To date, many (radio) chemists have developed various methods to introduce short-lived such as carbon-11 or fluorine-18, and expanded available range chemical structures small molecular-based probes. However, number useful probes life science research still limited. This mainly due insufficient radiolabeling reactions, limiting synthesizable Furthermore, densely functionalized complex structure compounds in interest impedes preparation precursors. address these issues, we proposed two strategies; molecular renovation strategy enables expeditious labeling precursors, other mimic designing radiolabelable probe development. account describes concepts our recent efforts realize them by developing borylations reactions.

Язык: Английский

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Mechanistic study on C(sp²)–F bond activation by a Ni⁰(silyl)-ate complex: an outer-sphere pathway via Ni⁰-mediated nucleophilic aromatic substitution

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(14), С. 3913 - 3923

Опубликована: Янв. 1, 2024

DFT calculations and AIMD simulations reveal C(sp 2 )–F bond activation by a Ni 0 (silyl)-ate complex, involving an outer-sphere pathway via -mediated S N Ar.

Язык: Английский

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Nickel and palladium catalysed cross-coupling: Factors effecting the oxidative addition step

Advances in physical organic chemistry, Год журнала: 2023, Номер unknown, С. 41 - 86

Опубликована: Янв. 1, 2023

Язык: Английский

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