Synfacts, Год журнала: 2023, Номер 19(10), С. 1038 - 1038
Опубликована: Сен. 14, 2023
Key words CB2R (cannabinoid 2 receptor) - β-arrestin2 (βarr2) pathway benzimidazole azo-arenes Baeyer–Mills reaction
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(29), С. 19609 - 19620
Опубликована: Июль 11, 2024
Azobenzenes (Ph-N═N-Ph) are known as the most widely studied molecular photoswitches, and recent rise of azoheteroarenes (Het-N═N-Ph or Het-N═N-Het) offers great opportunities to advance this already mature field. A common limitation is that azo-switches generally require harmful UV light for activation, which hinders their application across various fields. Despite efforts in developing visible-light azobenzenes over past few decades, potential heteroaryl azoswitches remains largely unexplored. This Perspective summarizes state-of-the-art advancements azoswitches, covering design strategies, structure-property relationship, applications. We highlight distinctive advantages research development switches. Furthermore, we discuss challenges emerging field propose solutions address crucial issues such spectral red-shift thermal half-life. Through paper, aim provide inspiration further exploration field, anticipation growing prosperity bright future azoheteroarene photoswitches.
Язык: Английский
Процитировано
29
Chemical Science, Год журнала: 2024, Номер 15(14), С. 5360 - 5367
Опубликована: Янв. 1, 2024
Arylazobenzimidazoles are photoswitchable privileged structures in medicinal chemistry. Experimental and theoretical studies identified compounds with visible light near-quantitative bidirectional photoswitching highly tunable Z -isomer stability.
Язык: Английский
Процитировано
9
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 7, 2024
Azo switches are widely employed as essential components in light-responsive systems. Here, we develop an azo-fluorescent switch that is visible and its processes can be monitored using fluorescence imaging. Visible light irradiation promotes isomerization, accompanied by changes enable the process to through Furthermore, document nanocavity size of liposome encapsulated nanoparticles containing azo isomerization show this change enables construction a nanoplatform for optically controlled release antimycotics. Also, natural activation loaded with antimycotic agent causes death Rhizoctonia solani. The results these double holding period comparison small molecule strategy used design imaging-guided light-controlled nano-antimycotic system applicable protocols delivery wide variety drugs.
Язык: Английский
Процитировано
8
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 19, 2024
Abstract Molecular photoswitches can undergo isomerization under light exposure, making them uniquely attractive for high spatiotemporal resolution remote control of biological functions. Visible and near‐infrared (NIR) light, with their low energy consumption, safety, strong tissue penetration, are particularly suitable applications. Therefore, developing visible‐ NIR light‐driven molecular use is great significance. This review introduces the most common presents state‐of‐art applications in bioimaging, biosensing, drug delivery, photocontrolled cancer phototherapy, photopharmacology. The opportunities challenges future development outlined.
Язык: Английский
Процитировано
8
Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. NAFLD encompasses a spectrum damage starting with steatosis and lipid disorders presented as hallmark. Cannabinoid-2 receptor (CB2R) endocannabinoids mainly expressed in immune cells. Our preliminary study revealed preventative role CB2R injury related to metabolism. In this study, we aimed explore underlying mechanism microbial community. High-fat diet-induced model was established mice. We found that expression significantly reduced mice CB2R-/- fed normal chow. Interestingly, cohousing or transplanted microbiota from WT mice, treatment an antibiotic cocktail ameliorated phenotype The gut dysbiosis including increased Actinobacteriota decreased Bacteroidota similar patients Microbial functional analysis metabolomics profiling obviously disturbed tryptophan metabolism which were also seen Correlation network showed disordered metabolites such indolelactic acid (ILA) xanthurenic mediated by severity indicators. vitro vivo validation experiments enriched ILA aggravated phenotypes. These results demonstrate involvement NAFLD, microbiota-mediated metabolites. findings highlight associated microbes promising targets for NAFLD.
Язык: Английский
Процитировано
1
Chemistry - A European Journal, Год журнала: 2024, Номер 30(20)
Опубликована: Фев. 2, 2024
The development of synthetically accessible photoswitches showing an efficient performance in aqueous medium has recently become urgent task due to the rapid progress photopharmacology and novel biomedical applications. In response this challenge, work, aurone derivatives are introduced as a class visible-light for medium. general, aurones exhibit superior water, including significantly higher quantum yields, compared with other indigoid (hemithioindigo hemiindigo). Especially remarkable half-lives photoinduced E-isomers reaching up 7 years. Further modification scaffold substituents that increase water solubility does not affect most photoswitching characteristics even improves some them. highly advantageous property profile make them perfect platform design light-controllable systems areas requiring
Язык: Английский
Процитировано
6
British Journal of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 11, 2024
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and importance as drug targets. Although numerous drugs the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, adverse effects triggered by available unbiased GPCR modulators, limit use therapeutic value. In this context, elucidation of biased has opened up new pharmacological avenues holding promise safer therapeutics. Functionally selective ligands favour receptor conformations facilitating recruitment specific effectors modulation associated pathways. This review surveys current discovery landscape GPCR‐biased modulators with a focus on recent advances. Understanding biological preferential coupling is at different stages depending family. Therefore, individual families, we present compilation functionally reported past few years. doing so, dissect relevance, molecular determinants potential clinical applications.
Язык: Английский
Процитировано
6
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(20), С. 4123 - 4134
Опубликована: Янв. 1, 2024
Push–pull stilbenyl-azopyrrole dyes are efficiently obtained via a Heck cross-coupling reaction. Modifications of the acceptor character EWG might accelerate cis – trans photo-isomerization.
Язык: Английский
Процитировано
5
Drugs and Drug Candidates, Год журнала: 2025, Номер 4(1), С. 2 - 2
Опубликована: Янв. 9, 2025
The Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A) held its 32nd annual conference August 2024 at University Coimbra, Portugal. There were 8 keynote presentations, 12 early career researcher oral and 34 poster presentations. Four awards delivered, two best communications
Язык: Английский
Процитировано
0
Chemical Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Electrochemically grown heteroatoms containing organic films utilized to fabricate crossbar molecular junctions as classical capacitors for energy storage applications.
Язык: Английский
Процитировано
0