Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Nature
often
provides
invaluable
insights
into
technological
innovation
and
the
construction
of
nanomaterials.
Inspired
by
pitaya
fruit's
strategy
wrapping
seeds
within
its
pulp
to
enhance
seed
survival,
a
unique
nanocomposite
based
on
metal‐organic
framework
(MOF)‐encapsulated
CuS
nanoparticles
(NPs)
is
developed.
This
design
effectively
addresses
challenge
short
retention
time
afforded
NPs
for
therapeutic
imaging
purposes.
The
MOF
acts
as
“pitaya
pulp”
protecting
internal
(“pitaya
seeds”),
thereby
increasing
their
in
vivo.
system
exhibits
triple‐enzyme‐mimicking
activities
proposed
application
photoacoustic
magnetic
resonance
imaging‐guided
therapies,
including
chemodynamic
therapy,
photothermal
cuproptosis‐related
therapy.
exceptional
enzyme‐mimicking
superoxide
dismutase,
catalase,
peroxidase
not
only
produce
oxygen
alleviate
hypoxia
but
also
generate
reactive
species
(ROS)
storm
effective
tumor
destruction.
By
combining
these
multienzymatic
properties,
superior
performance,
Cu‐induced
cuproptosis,
nanozyme‐treated
mice
exhibited
an
84%
inhibition
growth—approximately
double
effect
observed
treated
with
alone.
study
presents
smart
integrating
modalities,
achieving
outcomes
precise
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101119 - 101119
Опубликована: Июнь 11, 2024
Cancer
represents
a
significant
threat
to
human
health,
with
the
use
of
traditional
chemotherapy
drugs
being
limited
by
their
harsh
side
effects.
Tumor-targeted
nanocarriers
have
emerged
as
promising
solution
this
problem,
they
can
deliver
directly
tumor
site,
improving
drug
effectiveness
and
reducing
adverse
However,
efficacy
most
nanomedicines
is
hindered
poor
penetration
into
solid
tumors.
Nanomotors,
capable
converting
various
forms
energy
mechanical
for
self-propelled
movement,
offer
potential
enhancing
delivery
deep
regions.
External
force-driven
nanomotors,
such
those
powered
magnetic
fields
or
ultrasound,
provide
precise
control
but
often
necessitate
bulky
costly
external
equipment.
Bio-driven
propelled
sperm,
macrophages,
bacteria,
utilize
biological
molecules
self-propulsion
are
well-suited
physiological
environment.
constrained
lifespan,
inadequate
speed,
immune
responses.
To
address
these
issues,
nanomotors
been
engineered
propel
themselves
forward
catalyzing
intrinsic
"fuel"
in
microenvironment.
This
mechanism
facilitates
through
barriers,
allowing
them
reach
regions
targeted
delivery.
In
regard,
article
provides
review
microenvironment-activatable
(fueled
hydrogen
peroxide,
urea,
arginine),
discusses
prospects
challenges
clinical
translation,
aiming
new
insights
safe,
efficient,
treatment
cancer
therapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Nature
often
provides
invaluable
insights
into
technological
innovation
and
the
construction
of
nanomaterials.
Inspired
by
pitaya
fruit's
strategy
wrapping
seeds
within
its
pulp
to
enhance
seed
survival,
a
unique
nanocomposite
based
on
metal‐organic
framework
(MOF)‐encapsulated
CuS
nanoparticles
(NPs)
is
developed.
This
design
effectively
addresses
challenge
short
retention
time
afforded
NPs
for
therapeutic
imaging
purposes.
The
MOF
acts
as
“pitaya
pulp”
protecting
internal
(“pitaya
seeds”),
thereby
increasing
their
in
vivo.
system
exhibits
triple‐enzyme‐mimicking
activities
proposed
application
photoacoustic
magnetic
resonance
imaging‐guided
therapies,
including
chemodynamic
therapy,
photothermal
cuproptosis‐related
therapy.
exceptional
enzyme‐mimicking
superoxide
dismutase,
catalase,
peroxidase
not
only
produce
oxygen
alleviate
hypoxia
but
also
generate
reactive
species
(ROS)
storm
effective
tumor
destruction.
By
combining
these
multienzymatic
properties,
superior
performance,
Cu‐induced
cuproptosis,
nanozyme‐treated
mice
exhibited
an
84%
inhibition
growth—approximately
double
effect
observed
treated
with
alone.
study
presents
smart
integrating
modalities,
achieving
outcomes
precise
