Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Hydrogen
peroxide
(H2O2)
plays
a
vital
role
in
various
physiological
and
pathological
processes.
Thus,
fluorescent
probes
of
H2O2
are
powerful
tools
for
the
investigation
H2O2-related
diseases.
However,
developing
that
do
not
irreversibly
consume
presents
significant
challenge.
In
this
work,
we
introduce
carbonate
ester
as
nonconsumptive
recognizing
molecule
to
construct
RES-6C
novel
probe
H2O2.
exhibited
selective
sensitive
turn-on
fluorescence
response
H2O2,
enabling
detection
cells
without
disturbing
cellular
redox
status.
has
been
applied
study
nonalcoholic
fatty
liver
disease,
revealing
peroxisomes
mitochondria
contribute
production
similar
extent
during
very-long-chain
acid
metabolism
first
time.
It
also
enabled
imaging
LPS-induced
inflammation
mouse
model.
Overall,
serves
versatile
tool
monitor
tissues
vivo,
providing
new
insights
into
design
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Hydrogen
peroxide
(H2O2)
plays
a
vital
role
in
various
physiological
and
pathological
processes.
Thus,
fluorescent
probes
of
H2O2
are
powerful
tools
for
the
investigation
H2O2-related
diseases.
However,
developing
that
do
not
irreversibly
consume
presents
significant
challenge.
In
this
work,
we
introduce
carbonate
ester
as
nonconsumptive
recognizing
molecule
to
construct
RES-6C
novel
probe
H2O2.
exhibited
selective
sensitive
turn-on
fluorescence
response
H2O2,
enabling
detection
cells
without
disturbing
cellular
redox
status.
has
been
applied
study
nonalcoholic
fatty
liver
disease,
revealing
peroxisomes
mitochondria
contribute
production
similar
extent
during
very-long-chain
acid
metabolism
first
time.
It
also
enabled
imaging
LPS-induced
inflammation
mouse
model.
Overall,
serves
versatile
tool
monitor
tissues
vivo,
providing
new
insights
into
design
