Recent Developments in Single-Entity Electrochemistry
Analytical Chemistry,
Год журнала:
2024,
Номер
96(20), С. 8036 - 8055
Опубликована: Май 10, 2024
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ASAPPREVReviewNEXTRecent
Developments
in
Single-Entity
ElectrochemistryL.
ZhangL.
ZhangDepartment
of
Chemistry,
Texas
A&M
University,
College
Station,
77845,
United
StatesMore
by
L.
ZhangView
Biography,
O.
J.
WahabO.
WahabDepartment
WahabView
Biographyhttps://orcid.org/0000-0003-4280-9089,
A.
JallowA.
JallowDepartment
JallowView
Biographyhttps://orcid.org/0000-0003-2173-4137,
Z.
O'DellZ.
O'DellDepartment
Temple
Philadelphia,
Pennsylvania
19122,
O'DellView
Biographyhttps://orcid.org/0000-0002-7779-596X,
T.
PungsrisaiT.
PungsrisaiDepartment
PungsrisaiView
S.
SridharS.
SridharDepartment
SridharView
Biographyhttps://orcid.org/0000-0003-3379-1630,
K.
VernonK.
VernonDepartment
VernonView
Willets*K.
WilletsDepartment
States*Email:
[email
protected]More
WilletsView
Biographyhttps://orcid.org/0000-0002-1417-4656,
and
Baker*L.
BakerDepartment
BakerView
Biographyhttps://orcid.org/0000-0001-5127-507XCite
this:
Anal.
Chem.
2024,
XXXX,
XXX,
XXX-XXXPublication
Date
(Web):May
10,
2024Publication
History
Published
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May
2024https://doi.org/10.1021/acs.analchem.4c01406©
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(7
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Get
e-AlertscloseSUBJECTS:Collisions,Electrodes,Metal
nanoparticles,Nanoparticles,Nanopores
e-Alerts
Язык: Английский
Dynamic Features Driven by Stochastic Collisions in a Nanopore for Precise Single-Molecule Identification
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Nanopore
technology
holds
great
potential
for
single-molecule
identification.
However,
extracting
meaningful
features
from
ionic
current
signals
and
understanding
the
molecular
mechanisms
underlying
specific
remain
unresolved.
In
this
study,
we
uncovered
a
distinctive
pattern
in
K238Q
aerolysin
nanopore,
characterized
by
transient
spikes
superimposed
on
two
stable
transition
states.
By
employing
neural
network
model,
demonstrated
that
these
previously
overlooked
dynamic
spike
exhibit
superior
discriminative
power,
improving
accuracy
44%
to
93%.
We
identified
states
result
simultaneous
interactions
of
ssDNA
with
sensitive
sites
nanopore.
The
proposed
stochastic
collision
model
offers
mechanistic
framework
interpreting
generation
features.
This
indicates
continuous
transitions
facilitate
iterative,
comprehensive
snapshots
nanopores.
Our
findings
introduce
new
approach
optimizing
nanopore
capture
complex
substantially
improve
Язык: Английский
Nanopore sensing and beyond: Electrochemical systems for optically-coupled single-entity studies, stimulus-responsive gating applications, and point-of-care sensors
Sensors and Actuators Reports,
Год журнала:
2024,
Номер
8, С. 100225 - 100225
Опубликована: Июль 17, 2024
Nanopores
play
essential
roles
in
biological
processes,
such
as
ion
channels
and
pumps
cellular
membranes,
technological
applications
DNA
sequencing.
Advancements
nanofabrication
techniques
have
enabled
the
routine
integration
of
nanopores
into
solid-state
devices,
resulting
a
plethora
analytical
applications.
This
review
explores
recent
developments
nanopore-enabled
electrochemical
systems,
which
transcended
traditional
resistive
pulse
sensing
to
offer
novel
capabilities
single-entity
studies,
stimulus-responsive
gating,
point-of-care
diagnostics.
We
highlight
studies
on
design
utility
nanopore
electrode
arrays,
serve
nanocontainers
capable
isolating
analyzing
single
entities,
extend
discussion
hierarchically
organized,
systems
that
regulate
species
transport
across
nanopores,
enriching
analytes
for
ultrasensitive
detection.
In
addition,
we
utilization
probe-assisted
sensing,
demonstrating
its
efficacy
selectively
binding
detecting
target
molecules
ions.
Finally,
outline
future
directions
nanopore-based
enhance
robustness,
achieve
high-throughput
analysis,
incorporate
artificial
intelligence
materials
data
promising
transformative
impacts
diagnostics
research.
Язык: Английский
Interpretation of stochastic electrochemical data
Current Opinion in Electrochemistry,
Год журнала:
2024,
Номер
46, С. 101505 - 101505
Опубликована: Апрель 22, 2024
Stochastic
electrochemical
measurement
has
come
of
age
as
a
powerful
analytical
tool
in
corrosion
science,
electrophysiology,
and
single-entity
electrochemistry.
It
relies
on
the
fundamental
trait
that
most
processes
are
stochastic
discrete
nature.
single
entity
probes
charge
transfer
from
few
or
even
one
electroactive
species.
In
corrosion,
measurements
capture
either
average
amplitude/frequency
many
events
taking
place
spontaneously
probe
transients,
signifying
localized
dissolution.
The
principles
vary
single-entity,
yet
main
quantifiable
values
commonly
frequency
amplitude
events.
This
perspective
delves
into
methodologies
for
analysis
deconvolution
signals
Ranging
visual
assessment
transients
to
time/frequency
analyses
data
state-of-the-art
machine
learning,
these
mainly
aim
at
identifying
patterns,
singular
events,
rates
signals.
Язык: Английский
Collision electrochemistry: A simple methodology for investigating complex processes
Current Opinion in Electrochemistry,
Год журнала:
2024,
Номер
45, С. 101518 - 101518
Опубликована: Апрель 15, 2024
Язык: Английский
Single Entity Electrochemistry in Motion
Electroanalysis,
Год журнала:
2025,
Номер
37(3)
Опубликована: Март 1, 2025
Single
entity
electrochemistry
(SEE)
finds
exciting
application
in
analytical
chemistry.
Multiple
methodologies
have
been
tailored
to
measure
conventional
quantities
such
as
concentration
and
size
for
a
large
variety
of
particles.
Intense
effort
is
also
dedicated
investigation
chemical
dynamics
electro‐catalysis.
This
mini‐review
will
focus
its
attention
the
analysis
motion
particles
at
interface
near
interface.
The
velocity
types
(lateral,
transversal,
rotational)
be
discussed
wide
range
including
solid
metal
polystyrene
well
soft
liquid
droplets
gas
bubbles.
A
new
perspective
on
SEE
given
by
discussing
phase
boundaries
within
Язык: Английский
Advanced Algorithm for Step Detection in Single-Entity Electrochemistry: A Comparative Study of Wavelet Transforms and Convolutional Neural Networks
Faraday Discussions,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 4, 2024
In
this
study,
two
approaches
for
step
detection
in
single-entity
electrochemistry
data
are
developed
and
compared:
discrete
wavelet
transforms
convolutional
neural
networks.
Язык: Английский
Computer-Assisted Processing of Current Step Signals in Single Blocking Impact Electrochemistry
ACS Measurement Science Au,
Год журнала:
2024,
Номер
4(5), С. 585 - 592
Опубликована: Сен. 6, 2024
Current
step
signals
related
to
single-entity
collisions
in
blocking
impact
electrochemistry
were
analyzed
by
computer-assisted
processing
for
estimating
the
size
distributions
of
various
particles.
In
this
work,
three
different
types
entities
studied
single
electrochemistry:
polystyrene
nanospheres
(350
nm
diameter)
and
microspheres
(1
μm
diameter),
phospholipid
liposomes
(300
two
strains
Gram-negative
bacillus
bacteria
(
Язык: Английский