Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(24), С. 5151 - 5159
Опубликована: Авг. 29, 2024
Abstract
A
copper
or
silver‐catalyzed
cascade
addition/5‐
exo‐dig
cyclization/isomerization
reaction
of
isothiocyanate
with
ynone
has
been
developed.
This
strategy
enables
the
synthesis
a
variety
(
Z
)‐2‐ylidene‐5‐aminothiophen‐3‐one
derivatives
diverse
substitutions
in
single
vessel.
The
method
is
featured
pot‐economy
as
well
regio‐
and
‐selectivity.
Several
biologically
active
molecules
could
be
modified
using
this
strategy.
Moreover,
relevant
indole‐fused
indole‐substituted
thiophenone
were
also
assembled
one
pot
by
merging
other
bond
formation
methods.
Based
on
experiments
related
reports,
pathway
triggered
addition
ynone‐derived
radical
towards
C(
sp
)‐atom
was
proposed
to
elucidate
probable
process
transformation.
Abstract
The
stereoselective
synthesis
of
β-amino
acids
has
attracted
major
attention
among
the
synthetic
community
in
recent
years.
This
review
provides
an
overview
important
advances
chiral
acid
over
past
decade.
It
covers
development
enantioselective
methods
using
transition-metal
complexes
or
organocatalysts,
mainly
including
catalytic
asymmetric
hydrogenation,
Mannich
reaction,
multicomponent
reactions
diazo
compounds,
and
conjugate
addition.
Additionally,
optically
active
by
other
approaches
are
also
summarized.
1
Introduction
2
Strategies
towards
Asymmetric
Synthesis
β-Amino
Acids
2.1
Hydrogenation
2.2
Reaction
2.3
Conjugate
Addition
2.4
Multicomponent
Reactions
2.5
Miscellaneous
2.5.1
from
Chiral
Amines
2.5.2
Isoxazolidinones
2.5.3
Other
Methodologies
3
Summary
Outlook
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(22), С. 6311 - 6318
Опубликована: Янв. 1, 2024
Co-catalyzed
asymmetric
reductive
addition
of
ketimine
with
cyclopropyl
chloride
has
been
realized
to
access
diverse
chiral
amino
esters
bearing
fragments
broad
functional
group
tolerance
and
excellent
enantioselectivities.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(24), С. 5151 - 5159
Опубликована: Авг. 29, 2024
Abstract
A
copper
or
silver‐catalyzed
cascade
addition/5‐
exo‐dig
cyclization/isomerization
reaction
of
isothiocyanate
with
ynone
has
been
developed.
This
strategy
enables
the
synthesis
a
variety
(
Z
)‐2‐ylidene‐5‐aminothiophen‐3‐one
derivatives
diverse
substitutions
in
single
vessel.
The
method
is
featured
pot‐economy
as
well
regio‐
and
‐selectivity.
Several
biologically
active
molecules
could
be
modified
using
this
strategy.
Moreover,
relevant
indole‐fused
indole‐substituted
thiophenone
were
also
assembled
one
pot
by
merging
other
bond
formation
methods.
Based
on
experiments
related
reports,
pathway
triggered
addition
ynone‐derived
radical
towards
C(
sp
)‐atom
was
proposed
to
elucidate
probable
process
transformation.
