Emerging Trends in DNA Nanotechnology-Enabled Cell Surface Engineering

JACS Au, Год журнала: 2025, Номер 5(2), С. 550 - 570

Опубликована: Фев. 6, 2025

Cell surface engineering is a rapidly advancing field, pivotal for understanding cellular physiology and driving innovations in biomedical applications. In this regard, DNA nanotechnology offers unprecedented potential precisely manipulating functionalizing cell surfaces by virtue of its inherent programmability versatile functionalities. Herein, Perspective provides comprehensive overview emerging trends engineering, focusing on key nanostructure-based tools, their roles regulating physiological processes, We first discuss the strategies integrating molecules onto surfaces, including attachment oligonucleotides higher-order nanostructure. Second, we summarize impact DNA-based various such as membrane protein degradation, signaling transduction, intercellular communication, construction artificial components. Third, highlight applications DNA-engineered targeted therapies cancer inflammation, well capture/protection diagnostic detection. Finally, address challenges future directions nanotechnology-based engineering. This aims to provide valuable insights rational design contributing development precise personalized medicine.

Язык: Английский

---

Advances in Cell Separation: Harnessing DNA Nanomaterials for High-Specificity Recognition and Isolation

Chem & Bio Engineering, Год журнала: 2025, Номер 2(3), С. 171 - 181

Опубликована: Янв. 31, 2025

Advancements in cell separation are essential for understanding cellular phenotypes and functions, with implications both research therapeutic applications. This review examines the evolution of techniques, categorizing them into physical affinity-based methods, a primary focus on latter due to its high specificity. Among affinity DNA nanomaterials have emerged as powerful tools biomolecular recognition owing their unique properties diverse range nanostructures. We discuss various nanomaterials, including linear aptamers, multivalent constructs, origami, hydrogels roles separation. Each section highlights distinctive characteristics these nanostructures, providing examples from recent studies that demonstrate applications isolation release. also compare four outlining individual contributions identifying remaining challenges opportunities further development. conclude nanotechnology holds great promise transformative solution separation, particularly context personalized therapeutics.

Язык: Английский

---

Body-worn and self-powered flexible optoelectronic device for metronomic photodynamic therapy

npj Flexible Electronics, Год журнала: 2024, Номер 8(1)

Опубликована: Сен. 30, 2024

Язык: Английский

---

Advances in Stimuli-Responsive Injectable Hydrogels for Biomedical Applications

Biomaterials Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The development of new multi-responsive injectable hydrogels with cascades or even synergistic effects will be great significance in the field precision medicine.

Язык: Английский

---

DNA Nanostructures‐Based In Situ Cancer Vaccines: Mechanisms and Applications

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Current tumor vaccines suffer from inadequate immune responsive due to the insufficient release of antigens, low infiltration, and immunosuppressive microenvironment. DNA nanostructures with their ability precisely engineer, controlled release, biocompatibility, capability augment immunogenicity microenvironment, have gained significant attention for potential revolutionize vaccine designing. This review summarizes various applications in construction situ cancer vaccines, which can generate tumor‐associated antigens directly damaged tumors immune‐stimulation. The mechanisms components are listed, specific strategies constructing using explored underlying action elucidated. immunogenic cell death (ICD) induced by chemotherapeutic agents, photothermal therapy (PTT), photodynamic (PDT), radiation (RT) related building systematically summarized. different immunotherapy elaborated, exerts precise, long‐lasting, robust responses. current challenges future prospectives proposed. provides a holistic understanding evolving role development.

Язык: Английский

---

External Stimuli-Driven Catalytic Hydrogels for Biomedical Applications

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening understanding of applications.

Язык: Английский

---

DNA hydrogels and their derivatives in biomedical engineering applications

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 29, 2024

Deoxyribonucleotide (DNA) is uniquely programmable and biocompatible, exhibits unique appeal as a biomaterial it can be precisely designed programmed to construct arbitrary shapes. DNA hydrogels are polymer networks comprising cross-linked strands. As present programmability, biocompatibility, stimulus responsiveness, they extensively explored in the field of biomedicine. In this study, we provide an overview recent advancements hydrogel technology. We outline different design philosophies methods preparation, discuss its special physicochemical characteristics, highlight various uses biomedical domains, such drug delivery, biosensing, tissue engineering, cell culture. Finally, current difficulties facing their potential future development.

Язык: Английский

---

“Internal Trouble and Outside Aggression” Strategy: Energy Deprivation Synergized With cGAS‐STING Pathway Activation for Stimuli‐Responsive Photodynamic‐Metal‐Metabolic Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Abstract The aberrant metabolic activities of tumor cells not only facilitate proliferation but also impair immune cell function and cause an immunosuppressive microenvironment (TME). Thus, reshaping the TME while activating innate immunity is highly desirable challenging. Herein, a multifunctional immunomodulator engineered for near‐infrared light (NIR)‐triggered photodynamic‐metal‐metabolic immunotherapy via “internal trouble outside aggression” strategy. Specifically, endogenous exogenous stimuli‐responsive nanoagent prepared consisting photosensitizer chlorin e6 (Ce6) modified dense silica‐coated rare earth‐doped nanoparticles (ReNPs@SiO 2 (Ce6)), with in situ grown ZIF‐8 on surface loading glucose transporter‐1 (GLUT‐1) inhibitor Fasentin glutaminase‐1 bis‐2‐(5‐phenylacetamido‐1,3,4‐thiadiazol‐2‐yl)ethyl sulfide (BPTES). as‐obtained final product denoted as ReSZ(FB). ReSZ(FB) induces‐ mitochondrial damage releases DNA (mtDNA) NIR‐mediated PDT. Subsequently, Zn 2+ from collaborates mtDNA to activate cGAS‐STING pathway, initiating robust tumor‐specific response. Concurrently, BPTES triggeres energy deprivation by blocking uptake inhibiting glutamine decomposition, thereby reprogramming TME, alleviating immunosuppression. Tumor are damaged trapped into trouble” combining PDT deprivation, sharply enhanced lethality exposes cancer “outside aggression”. Overall, this provides promising paradigm therapy.

Язык: Английский

---

In-situ injectable hydrogel for near-infrared-regulated hyperthermic perfusion therapy of triple-negative breast cancer

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

---

Smart nucleic acid nanodrug delivery system for precision therapeutics

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216673 - 216673

Опубликована: Апрель 3, 2025

Язык: Английский

---