Nanomaterial-functionalized electrospun scaffolds for tissue engineering

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер unknown, С. 1 - 43

Опубликована: Сен. 11, 2024

Tissue engineering has emerged as a biological alternative aimed at sustaining, rehabilitating, or enhancing the functionality of tissues that have experienced partial complete loss their operational capabilities. The distinctive characteristics electrospun nanofibrous structures, such elevated surface-area-to-volume ratio, specific pore sizes, and fine fiber diameters, make them suitable effective scaffolds in tissue engineering, capable mimicking functions targeted tissue. However, nanofibers, whether derived from natural synthetic polymers combinations, often fall short replicating multifunctional attributes extracellular matrix (ECM). To address this, nanomaterials (NMs) are integrated into polymeric through various functionalization techniques to enhance properties. Incorporation NMs imparts unique features, including high surface area, superior mechanical properties, compositional variety, structural adaptability, exceptional porosity, enhanced capabilities for promoting cell migration proliferation. This review provides comprehensive overview types NMs, methodologies used integration scaffolds, recent advancements NM-functionalized regenerating bone, cardiac, cartilage, nerve, vascular tissues. Moreover, main challenges, limitations, prospects elaborated.

Язык: Английский

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Editorial: Exploring the potential of nanobiomaterials in biomedical engineering: assessing biocompatibility, toxicity, and future prospects

Frontiers in Chemistry, Год журнала: 2024, Номер 12

Опубликована: Окт. 23, 2024

The future of NBMs holds immense promise. By leveraging the capabilities nanotechnology and emulating intricate structures living tissues, offer exciting possibilities for diverse biomedical applications (Figure 1). These include targeted drug delivery systems to advanced implants improve human health. However, this progress hinges on a commitment rigorous safety assessments deep understanding how interact with biological systems. Through ongoing research development, can transform we diagnose, treat, prevent diseases, heralding new era personalized medicine. This special issue explores vital interactions between cells/tissues, focusing factors such as size, morphology, shape, surface chemistry NBM influence toxicity, biocompatibility, immunogenicity. elucidating these structure-function relationships, aim facilitate creation innovative tailored properties applications. includes three papers two review articles exploring recent advances in design, preparation, biocompatibility assessment NBMs.Guedri et al. investigated potential using alumina-ferrite (Al2O3-Fe3O4) hybrid nanoparticles thermal various fields, including biomedicine, electronics, mechanical engineering. 11 Their study focused interaction blood over 3D surface, considering like nonlinear radiation, stretching, velocity slippage, magnetic field. A mathematical model was developed nanofluid similarity rules. Numerical simulations were performed analyze behavior within blood. results showed that strong field effectively controlled motion nanoparticles, while stretching increased fluid movement. Thermal radiation found enhance both Al2O3-Fe3O4/blood Al2O3/blood. In iron sulfide-based nanozymes (ISNs), Shan highlighted growing interest due their stability, ease tunability. 12 They ISNs, widely studied nanomaterial enzyme-mimicking properties, outlining classification catalytic mechanisms followed by detailed examination use biosensors, tumor therapy, antibacterial other areas, underlining promise improving health.In another study, Puri explored green synthesis selenium (SeNPs) Terminalia arjuna bark extract. 13 abundant phenolics, flavonoids, tannins extract acted capping stabilizing agents, enabling formation stable, negatively charged, spherical TA-SeNPs. biogenic SeNPs exhibited excellent antioxidant, antibacterial, anticancer activities, making them promising candidates Notably, TA-SeNP-incorporated gel displayed desirable topical use. highlights safe sustainable development nanomedicines.Roma reviewed advancements graphene its derivatives dental 14 Highlighting unique activity, authors discuss methods, material characteristics, uses graphene-based materials. concludes challenges nanomaterials dentistry, aiming stimulate further research.A Dar effects nutrient sources rice growth yield. 15 Eight practices evaluated, recommended fertilizer dose (RFD), RFD silicon supplement, organic manure (FYM). treatment basal application Vigore (a commercial product) spray at panicle initiation (PI) stage (N3) resulted highest plant height, number tillers, density, weight, grain approach yielded 22-25% more than FYM or alone. suggests timing significantly yield.Altogether, presented highlight significant nanobiomaterials. We extend our sincere gratitude all contributing sharing valuable insights solutions. Special thanks go editors reviewers whose expertise enhanced quality papers. Despite advancements, remain. Future success deeper Continued hold revolutionize disease diagnosis, treatment, prevention, paving way trust will be informative inspiring, particularly young scholars eager contribute research.

Язык: Английский

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Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Non-small cell lung cancer (NSCLC) represents the most prevalent form of cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is standard treatment for NSCLC, but resistance and severe side effects present significant clinical challenges. Recently, novel tetravalent platinum compounds have attracted interest. While numerous studies concentrate their functional modifications targeted delivery, tumor-induced frequently overlooked. Previous compound demonstrated antitumor activity, yet proved ineffective against cells exhibiting to cisplatin. In order enhance efficacy potential applications in glutathione (GSH)-responsive albumin nanoquadrivalent (HSA@Pt) been constructed. light previous research into drug conjugation, this study was develop combined chemo-immunotherapy approach. The HSA@Pt high low toxicity, with tumor accumulation. Furthermore, tetrathiomolybdate (TM) has exert synergistic inhibitory effect Cu²⁺ Transporting Beta Polypeptide (ATP7B) Programmed Death Ligand 1 (PD-L1), impede efflux, induce cellular stress, activate immunity. findings suggest HSA@Pt's use strategy enhancing utility established drugs through sensitization.

Язык: Английский

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