Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Advanced Functional Materials, Год журнала: 2024, Номер 34(36)

Опубликована: Март 29, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), emerged a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, remarkable chemical stability, undergone comprehensive investigation extensive exploration within realm of biological theranostics. This work aims to provide summary advancements development design strategies NIR‐II BODIPY fluorophores tailored advanced phototheranostics. Initially, elucidates several representative strategies, concluding electron‐programming strategy, extension conjugated backbone, J‐aggregation strategic establishment activatable fluorophores, which enhance skeletons. Subsequently, developments fluorescent BODIPY‐based nanoplatforms applications are intricately elaborated. In conclusion, this outlines future efforts directions refining meet evolving clinical demands. It is anticipated that contribution may feasible reference thereby advancing their potential practices.

Язык: Английский

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Zwitterionic Photosensitizer‐Assembled Nanocluster Produces Efficient Photogenerated Radicals via Autoionization for Superior Antibacterial Photodynamic Therapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Abstract Photodynamic therapy (PDT) holds significant promise for antibacterial treatment, with its potential markedly amplified when using Type I photosensitizers (PSs). However, developing PSs remains a challenge due to lack of reliable design strategy. Herein, PS nanocluster is developed via self‐assembly zwitterionic small molecule (C3TH) superior PDT in vivo. Mechanism studies demonstrate that unique cross‐arranged C3TH within not only shortens intermolecular distance but also inhibits electronic‐vibrational coupling, thus facilitating photoinduced electron transfer form radical cation and anion autoionization reaction. Subsequently, these highly oxidizing or reducing radicals engage cascade photoredox generate efficient ·OH O 2 ‾·. As result, nanoclusters achieve 97.6% efficacy against MRSA at an ultralow dose, surpassing the commercial antibiotic Vancomycin by more than 8.8‐fold. These findings deepen understanding PDT, providing novel strategy PSs.

Язык: Английский

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Cold exposure therapy combined with bionic type I aggregation-induced emission photosensitizer for enhanced immunotherapy of breast cancer

Materials Today Bio, Год журнала: 2024, Номер 28, С. 101217 - 101217

Опубликована: Авг. 24, 2024

Cold exposure therapy (CE), as an inexpensive method, has shown great potential in cancer therapy. Exploring the combined anti-tumor mechanism of CE and traditional therapies (such photodynamic (PDT)) is exciting promising. Here, a bionic aggregation-induced emission photosensitizer system (named THL) designed for to enhance immunotherapy. THL inherits homologous targeting ability tumor derived exosomes, promoting enrichment at site. Under external illumination, generates hydroxyl radicals superoxide anions through type I PDT. In addition, mice are pretreated with cold exposure, which promotes mediated PDT reactive oxygen species (ROS) generation by reducing production ATP GSH tissue. This combination increases ROS within tumor, inhibits growth distant tumors, recurrent rechallenged tumors number cytotoxic CD8+T cells memory T cells. Compared alone, shows greater advantages The strategy provides new ideas

Язык: Английский

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Research Progress on Photocatalytic, Electrocatalytic and Photoelectrocatalytic Selectively Oxidation of 5-Hydroxymethylfurfural

Green Chemistry, Год журнала: 2024, Номер 26(21), С. 10739 - 10773

Опубликована: Янв. 1, 2024

This paper summarizes the latest research progress in selective photocatalytic, electrocatalytic, and photoelectrocatalytic oxidation of HMF, along with reaction mechanisms, advantages, challenges faced during HMF oxidation.

Язык: Английский

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Semiconducting Open‐Shell Radicals for Precise Tumor Activatable Phototheranostics

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Semiconducting open-shell radicals (SORs) have promising potential for the development of phototheranostic agents, enabling tumor bioimaging and boosting tumorous reactive oxygen species (ROS). Herein, a new class semiconducting perylene diimide (PDI), designated as PDI(Br)n with various numbers bromine (Br) atoms modified on PDI's bay/ortho positions is reported. demonstrated to transform into radical anion, [PDI(Br)n]•-, in reducing solution, typical g-value 2.0022. Specifically, [PDI(Br)4/6]•- generated weakly reductive tumor-mimicking solution exhibits high stability air. Quantum chemical kinetic simulation ultrafast femtosecond transient absorption spectroscopy indicate that [PDI(Br)6]•- has low π-π stacking energy (0.35 eV), fast electron transfer rate (192.4 ps) gap PDI(Br)6 (ΔES1, T1 = 1.307 eV, ΔES1, T2 0.324 eV) respectively, which together result excited-state charge characters. The nanoparticle radicals, [PDI(Br)6] NPs•-, specifically enable chemodynamic type-I photodynamic ROS generation tumors, including superoxide hydroxyl elicit immunogenic cell death effect. Also, NPs•- facilitate activatable bioimaging-guided therapy due their photoacoustic signal at 808 nm NIR-II emission 1115 nm. work paves way design SORs precise cancer theranostics.

Язык: Английский

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Nanoparticles for Photodynamic Therapy of Breast Cancer: A Review of Recent Studies

Molecules, Год журнала: 2025, Номер 30(7), С. 1571 - 1571

Опубликована: Март 31, 2025

Photodynamic therapy (PDT) is a therapeutic method based on the interaction between light and photosensitizer. Supported by nanoparticles, this represents promising interdisciplinary approach for treatment of many diseases. This article reviews latest 2024 developments in design applications nanoparticles dedicated to stand-alone PDT breast cancer. Strategies improve efficacy enhancing reactive oxygen species (ROS) production, precise delivery photosensitizers their stabilization systemic circulation are discussed, among others. Results from preclinical studies indicate significant improvements efficacy, including inhibition tumor growth, reduction metastasis improvement immune microenvironment. The potential these technologies expand medicine need further clinical trials confirm safety highlighted.

Язык: Английский

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Boosting Type-I ROS Production of Molecular Photosensitizers Using Bridge-Assisted Superexchange Coupling

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Bridge-assisted superexchange coupling capable of long-range electron transfer proves to be effective for charge separation. However, the exploitation this photochemical process in engineering reactive oxygen species (ROS) production remains unexplored. Herein, piperazine serves as a bridging unit facilitate cascade from donor site (CO) acceptor (CN) within COCN molecule, ultimately boosting generation superoxide radicals (O

Язык: Английский

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An Albumin‐Photosensitizer Supramolecular Assembly with Type I ROS‐Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness hypoxic solid tumor is limited by the oxygen‐dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, study reports a supramolecular photosensitizer, BSA@TPE‐BT‐SCT NPs, through encapsulating aggregation‐enhanced emission photosensitizer bovine serum albumin (BSA) to significantly enhance ROS, particularly less oxygen‐dependent I ROS for photodynamic immunotherapy. The abundant generated NPs induce multiple forms programmed cell death, including apoptosis, pyroptosis, ferroptosis. These multifaceted deaths synergistically facilitate release damage‐associated molecular patterns antitumor cytokines, thereby provoking robust immunity. Both vitro vivo experiments confirmed that elicited immunogenic dendritic maturation, activate T cell, reduce myeloid‐derived suppressor cells, leading inhibition both primary distant tumors. Additionally, BSA@TPE‐BT‐SCP also exhibited excellent performance humanized mice model, evidenced reduction senescent cells among these activated cells. findings advance development photosensitizers unveil important role enhancing immunogenicity.

Язык: Английский

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Semiconducting Perylene Diimide J‐aggregates Cross‐linked Hydrogel Enables High‐Efficiency Photothermal Controlled Release of Nitric Oxide for Antibiofilm Therapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Antibiofilm treatment, particularly drug-containing wound healing dressings, does not typically penetrate the robust protective extracellular polymeric substance of biofilm and eradicate bacteria. Here, a rational design nitric oxide (NO) donor N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine (BNN6)-based injectable hydrogel, is reported in which NO release can be triggered by photothermal effect owing to semiconducting perylene diimide (PDI) J-aggregation fibers. The synthetic PDI derivatives self-assembling into 0D nanoparticles then aggregating 1D J fiber accompanied absorbance red-shifting from 700 790 nm 852 nm. After encapsulating BNN6, "sandwich roll" (SR) like structure evenly crosslinked an hydrogel (SRH) exhibiting high convenience efficiency 72%, enables SRH achieve highly efficient photocontrol release. shows excellent injectability, shape adaptability, effective antibacterial efficacy over 99% E.coli S. aureus. remarkable vivo antibiofilm 99.58% laser irradiation. Furthermore, synergistic treatment displays ability eliminate inflammation, facilitate angiogenesis, promote collagen deposition, thereby significantly stimulating process wounds. versatile strategy for biofilm.

Язык: Английский

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Reprogrammed glycolysis-induced augmentation of NIR-II excited photodynamic/photothermal therapy

Biomaterials, Год журнала: 2025, Номер 320, С. 123235 - 123235

Опубликована: Март 4, 2025

Язык: Английский

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