Nanocomposites Based on Layered Double Hydroxides Loaded with Curcumin and Carbon Nitride Quantum Dots for Combined Chemotherapy and Chemodynamic Therapy of Tumors

Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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2D/2D ultra-thin porous carbon nitride/ZnIn₂S₄ heterojunctions for photocatalytic hydrogen evolution and methyl orange degradation

New Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Effective charge separation and sufficiently exposed active sites are both critical limiting factors for solar-driven photocatalytic technology.

Язык: Английский

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Enhanced Sonodynamic Cancer Therapy through Boosting Reactive Oxygen Species and Depleting Glutathione

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

The complex tumor microenvironment (TME) affects reactive oxygen species (ROS)-based therapies; breaking the limitations of TME to enhance effectiveness sonodynamic therapy (SDT) is full great challenges. Herein, iron atomically dispersed nanoparticles (Fe-N-C) were first reported as sonosensitizers with highly efficient ROS generation by overcoming limitations. Its peroxidase and catalase-like activities catalyze H2O2 produce toxic ·OH in situ O2, respectively, then O2 molecules adsorbed at Fe active sites obviously lower energy barrier for formation. Meanwhile, its glutathione-oxidase-like activity can rapidly consume glutathione (GSH) induce cell apoptosis ferroptosis. Density functional theory calculation results elucidate possible mechanism generation: are activated receiving sonoelectrons generate ·O2-, which further reacts H2O OH-. Then OH- oxidized sonoholes form ·OH. Fe-N-C displays a superior specificity SDT.

Язык: Английский

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2D Indium‐Vacancy‐Rich ZnIn₂S₄ Nanocatalysts for Sonocatalytic Cancer Suppression by Boosting Cancer‐Cell Pyroptosis

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Sonocatalytic therapy is gaining interest for its non‐invasive nature, precise control, and excellent tissue penetration, making it a promising approach treating malignant tumors. While defect engineering enhances electron hole separation to boost reactive oxygen species (ROS) generation, challenges in constructing effective traps compared severely limit ROS production. In this study, 2D ZnIn 2 S 4 ‐V nanosheets enriched are rationally designed with vacancies the efficient capture of electrons holes, which has achieved substantial sonocatalytic performance suppressing tumor growth. Compared pristine nanosheets, possess periodic electrostatic potential inherent their structure, effectively disrupt field, promote simultaneous migration charge carriers, inhibit recombination, thereby boosting production inducing cell pyroptosis via ROS‐NLRP3‐caspase‐1‐GSDMD pathway under ultrasound (US) irradiation. Furthermore, both exhibited remarkable biocompatibility. vitro vivo antineoplastic experiments demonstrate that promotes elimination, underscoring critical importance defect‐engineered optimization therapy.

Язык: Английский

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C3N4 nanosheet: sonopiezoelectric effect to boost NO therapy

Carbon, Год журнала: 2025, Номер unknown, С. 120330 - 120330

Опубликована: Апрель 1, 2025

Язык: Английский

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Narrow-Bandgap Iridium(III)-C₃N₅ Nanocomplex as an Oxygen Self-Sufficient Piezo-Sonosensitizer for Hypoxic Tumor Sonodynamic Immunotherapy

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Low immunogenicity and insufficient infiltration of immune cells are the main factors affecting therapeutic efficacy melanoma immunotherapy. Ultrasound-triggered sonodynamic therapy (SDT) based on piezoelectric materials has attracted substantial attention due to its high efficiency catalytic generation reactive oxygen species (ROS) induce immunogenic cell death (ICD). However, hypoxic environment in solid tumors hinders limits SDT effect. Herein, we construct a novel Ir-C3N5 nanocomplex that uses nitrogen-rich carbon nitride (C3N5) nanosheets as nanoligands Ir(tpy)Cl3 precursor. The newly formed exhibits narrowed band gap an enlarged dipole moment, resulting better electron-hole pair separation bending, contributing ROS burst upon ultrasonic activation. In addition, Ir(III) enables C3N5 catalyze degradation H2O2 O2, alleviating tumor hypoxia reinforcing efficacy. Mechanistically, by catalysis, can target lysosomes trigger autophagy inhibition caused lysosome rupture evoke pyroptosis. More importantly, cleaved caspase-1/GSDMD-N pyroptosis pathway activated was associated with ICD, effectively initiating innate adaptive immunity body for suppressing metastasis relapse.

Язык: Английский

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Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges

Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(2)

Опубликована: Май 10, 2025

Язык: Английский

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Amorphous Carbon and Cyano-Group Self-Modified P-Doped g-C3N4 for Boosting Photocatalytic H2 Evolution

Catalysts, Год журнала: 2024, Номер 14(8), С. 523 - 523

Опубликована: Авг. 13, 2024

Designing g-C3N4-based nanostructured photocatalysts is crucial to boosting their application in advancing clean energy and sustainable environmental solutions. In this study, cyano groups amorphous carbon self-modified P-doped g-C3N4 (PCNx) were designed prepared by one-pot calcination. Melamine phosphate was employed as a multifunctional precursor simultaneously achieve P-doping carbon/cyano group self-modification the photocatalyst. The molar ratio of urea melamine regulates content groups, which further enhances conductivity g-C3N4. Due high charge transfer process accelerated. As result, optimized carbon/cyano-group PCN2 photocatalyst led an excellent H2 production rate 157.86 µmol·g−1·h−1 under visible light, approximately 2.4 times 3 higher than those CN PCN. work developed alternative strategy for construction highly efficient photocatalysts.

Язык: Английский

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Donor–Acceptor Viologens with Through‐Space Conjugation for Enhanced Visible‐Light‐Driven Photocatalysis

Advanced Science, Год журнала: 2024, Номер 12(2)

Опубликована: Ноя. 21, 2024

Abstract A series of novel donor–acceptor (D–A) type viologens with through‐space conjugation (TSC) are synthesized. The synergistic effect D–A and TSC endow these compounds a narrower energy gap, excellent redox properties, strong absorption in the visible range (up to 450 nm), high efficiency intramolecular charge transfer (ICT). These also exhibit long‐lived separation state stable radical formation. Considering their impressive photophysical explored for visible‐light‐driven photocatalysis. As catalyst oxidative coupling reactions under light, compound 9 can achieve yield 94%, attributed its ICT effect. Additionally, hybridized into graphitic carbon nitride (g‐C₃N₄), enhances hydrogen production performance achieving an H 2 generation rate 4102 µmol h −1 g . This study highlights potential applications photocatalytic systems.

Язык: Английский

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Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Angewandte Chemie, Год журнала: 2024, Номер 137(1)

Опубликована: Авг. 22, 2024

Abstract Single‐atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)‐mediated cancer therapy. However, the high energy barriers of reaction intermediates on single‐atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi‐enzyme mimetic MoCu dual‐atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme‐like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near‐infrared II bio‐window endows remarkable photothermal conversion performance. Consequently, achieves high‐efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic

Язык: Английский

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