Abstract
Exploiting
single
molecular
species
synchronously
affording
powerful
second
near‐infrared
(NIR‐II)
fluorescence,
superior
photoacoustic
output,
prominent
reactive
oxygen
generation,
and
satisfactory
photothermal
conversion
is
supremely
appealing
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
electron
donor/π‐bridge
engineering
implemented
on
the
basis
of
6,7‐di(thiophen‐2‐yl)‐[1,2,5]thiadiazolo[3,4‐
g
]quinoxaline
moiety.
The
optimal
molecule,
namely
TPATO‐TTQ,
demonstrates
to
exhibit
those
notable
features
requested
by
exceptional
which
are
systematically
elucidated
through
depictions
excited‐state
energy
dissipation
pathways
influence
intramolecular
motion
photophysical
properties,
with
assistances
quantum
chemical
calculation
dynamic
simulation.
By
utilizing
TPATO‐TTQ
nanoparticles,
unprecedented
performance
NIR‐II
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐navigated
type
I
photodynamic‐photothermal
synergistic
therapy
orthotopic
breast
cancer
authenticates
precise
tumor
diagnosis
complete
ablation.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(51)
Опубликована: Авг. 26, 2024
Abstract
Pathogenic
infectious
diseases
have
persistently
posed
significant
threats
to
public
health.
Phototheranostics,
which
combines
the
functions
of
diagnostic
imaging
and
therapy,
presents
an
extremely
promising
solution
block
spread
pathogens
as
well
outbreak
epidemics
owing
its
merits
a
wide‐spectrum
activity,
high
controllability,
non‐invasiveness,
difficult
acquire
resistance.
Among
multifarious
phototheranostic
agents,
second
near‐infrared
(NIR‐II,
1000–1700
nm)
aggregation‐induced
emission
luminogens
(AIEgens)
are
notable
by
virtue
their
deep
penetration
depth,
excellent
biocompatibility,
balanced
radiative
nonradiative
decay
aggregation‐enhanced
theranostic
performance,
making
them
ideal
option
for
combating
pathogens.
This
minireview
provides
systematical
summary
latest
advancements
in
NIR‐II
AIEgens
with
emphasis
on
molecular
design
nanoplatform
formulation
fulfill
high‐efficiency
treating
bacterial
viral
pathogens,
classified
disease
models.
Then,
current
challenges,
potential
opportunities,
future
research
directions
presented
facilitate
further
progress
this
emerging
field.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 23, 2024
Cyanine
dye-containing
nanoparticles
have
widely
been
used
in
"all-in-one"
NIR
fluorescence
imaging
(FI)-guided
photothermal
therapy
(PTT)
because
of
their
intrinsically
large
extinction
coefficient
and
available
physical
chemical
modulation
methods
to
tune
absorption
emission
wavelengths.
The
combination
good
brightness
excellent
tumor-targeting
capacity
is
the
key
realize
efficient
NIR-II
FI-guided
PTT.
In
this
study,
by
covalently
decorating
absorptive
cyanine
dyes
with
bulky
AIE
motify,
we
demonstrate
how
steric
hindrance
suppresses
π-π
stacking-induced
quenching
contributes
FI
subcutaneous
glioblastoma.
resulting
dye
(C12-TPAE)
5
times
brighter
than
original
formulated
liposomal
C12-TPAE-AL
has
a
high
conversion
efficiency
62.4%,
colloidal
light
stability.
Importantly,
ApoE
peptide
absorbed
on
surface,
yielding
lipoprotein-mimicking
nanoparticles,
which
achieve
active
targeting
glioblastoma
PTT
without
tumor
recurrence
any
side
effects
normal
organs
(heart,
kidneys,
liver,
spleen,
or
lung).
This
research
highlights
facile
design
route
for
bright
emissive
indicates
that
biomimetic
theranostic
nanoplatforms
are
promising
candidates
future
precision
therapy.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Triple-negative
breast
cancer
(TNBC)
is
one
of
the
most
aggressive
and
challenging
subtypes
with
limited
treatment
options
poor
prognosis.
To
overcome
these
obstacles,
Ag-doped
SnSe
(ASS)
nanosheets
were
used
as
photonic
hyperthermia
agents
for
treating
TNBC.
ASS
featured
a
high
photothermal-conversion
efficiency
photon
effect.
Additionally,
biosafety
assessments,
including
hemolysis
assays
histopathological
analysis,
confirmed
that
was
biosafety.
These
findings
suggest
ASS,
in
synergy
second
near-infrared
biowindow
(NIR-II)
light
irradiation,
offers
noninvasive,
effective,
safe
therapeutic
strategy
This
innovative
approach
exemplifies
evolving
landscape
TNBC
treatment,
where
technology
biology
converge
to
offer
more
precise
personalized
therapies.
Chemistry of Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
Due
to
the
strong
light
trapping
ability,
good
biocompatibility,
and
easily
regulated
molecular
structure,
conjugated
polymers
are
becoming
a
promising
tool
for
phototheranostics
of
tumors,
which
can
achieve
both
precise
diagnosis
efficient
therapeutics.
Of
particular
interest
is
polymer-based
theranostic
agents
applying
second
near-infrared
(NIR-II)
window
(1000–1700
nm),
exhibit
great
potential
clinical
applications
on
account
extremely
long
wavelength.
Herein,
basic
mechanism,
advances
in
recent
6
years,
perspectives
polymer
NIR-II
toward
tumor
discussed
successively.
First,
mechanisms
most
widely
employed
modalities
presented.
In
view
heat
generation
property
under
photoexcitation,
fluorescence
imaging
(FLI)-guided
photothermal
therapy
(PTT)
photoacoustic
(PAI)-guided
PTT.
Then,
related
FLI-guided
PTT
technology,
PAI-guided
multimodel
theranostics
introduced.
Finally,
development
illustrated
practical
application
simultaneously
situ
tumor.
Near-infrared
(NIR)
phototheranostics
(PTs)
show
higher
tissue
penetration
depth,
signal-to-noise
ratio,
and
better
biosafety
than
PTs
in
the
ultraviolet
visible
regions.
However,
their
further
advancement
is
severely
hindered
by
poor
performances
short-wavelength
absorptions/emissions
of
PT
agents.
Among
reported
agents,
conjugated
small
molecular
nanoparticles
(CSMNs)
prepared
from
D-A-typed
photoactive
molecules
(CSMs)
have
greatly
mediated
this
deadlock
high
photostability,
distinct
chemical
structure,
tunable
absorption,
intrinsic
multifunctionality,
favorable
biocompatibility,
which
endows
CSMNs
with
more
possibilities
biological
applications.
This
review
aims
to
introduce
recent
progress
for
NIR
imaging,
therapy,
synergistic
a
comprehensive
summary
structures,
structure
types,
optical
properties.
Moreover,
working
principles
are
illustrated
photophysical
photochemical
mechanisms
light–tissue
interactions.
In
addition,
engineering
nanomodulation
approaches
CSMs
discussed,
an
emphasis
on
strategies
improving
extending
absorption
emission
wavelengths
range.
Furthermore,
vivo
investigation
solid
examples
imaging
different
scenarios,
therapy
2
modes,
combinational
functionalities.
concludes
brief
conclusion,
current
challenges,
future
outlook
CSMNs.
