Abstract
Exploiting
single
molecular
species
synchronously
affording
powerful
second
near‐infrared
(NIR‐II)
fluorescence,
superior
photoacoustic
output,
prominent
reactive
oxygen
generation,
and
satisfactory
photothermal
conversion
is
supremely
appealing
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
electron
donor/π‐bridge
engineering
implemented
on
the
basis
of
6,7‐di(thiophen‐2‐yl)‐[1,2,5]thiadiazolo[3,4‐
g
]quinoxaline
moiety.
The
optimal
molecule,
namely
TPATO‐TTQ,
demonstrates
to
exhibit
those
notable
features
requested
by
exceptional
which
are
systematically
elucidated
through
depictions
excited‐state
energy
dissipation
pathways
influence
intramolecular
motion
photophysical
properties,
with
assistances
quantum
chemical
calculation
dynamic
simulation.
By
utilizing
TPATO‐TTQ
nanoparticles,
unprecedented
performance
NIR‐II
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐navigated
type
I
photodynamic‐photothermal
synergistic
therapy
orthotopic
breast
cancer
authenticates
precise
tumor
diagnosis
complete
ablation.
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Abstract
Cancer
metastasis
remains
a
critical
factor
contributing
to
the
current
limitations
in
cancer
treatment.
Photothermal
immunotherapy
has
emerged
as
safe
and
potent
therapeutic
approach,
demonstrating
capability
suppress
tumor
growth
metastasis.
While
researchers
have
extensively
investigated
various
structural
modifications
enhance
photothermal
conversion
performance,
influence
of
molecular
configuration
received
comparatively
limited
attention.
In
this
study,
we
synthesized
two
isomers,
CZTBT
LVTBT,
which
possessed
distinct
configurations.
characterized
by
flatter
configuration,
exhibited
an
extended
absorption
wavelength
higher
molar
extinction
coefficient.
Its
excited
state
facilitated
stronger
rotation
for
non‐radiative
transitions,
leading
high
efficiency
(PCE)
36.3
%.
When
combined
with
R848,
LVTBT@R848
nanoparticles
(NPs)‐mediated
functioned
situ
vaccine,
promoting
maturation
dendritic
cells
(DCs),
T
cell
infiltration,
differentiation
natural
killer
(NK)
memory
cells,
thereby
activating
strong
immune
response.
Consequently,
it
significantly
inhibited
both
primary
distant
tumors,
while
also
limiting
lung
summary,
study
proposed
configuration‐mediated
transition
strategy
efficient
immunotherapy,
advancing
frontiers
organic
agents
(OPTAs)
design
synthesis.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Cancer
metastasis
remains
a
critical
factor
contributing
to
the
current
limitations
in
cancer
treatment.
Photothermal
immunotherapy
has
emerged
as
safe
and
potent
therapeutic
approach,
demonstrating
capability
suppress
tumor
growth
metastasis.
While
researchers
have
extensively
investigated
various
structural
modifications
enhance
photothermal
conversion
performance,
influence
of
molecular
configuration
received
comparatively
limited
attention.
In
this
study,
we
synthesized
two
isomers,
CZTBT
LVTBT,
which
possessed
distinct
configurations.
characterized
by
flatter
configuration,
exhibited
an
extended
absorption
wavelength
higher
molar
extinction
coefficient.
Its
excited
state
facilitated
stronger
rotation
for
non-radiative
transitions,
leading
high
efficiency
(PCE)
36.3
%.
When
combined
with
R848,
LVTBT@R848
nanoparticles
(NPs)-mediated
functioned
situ
vaccine,
promoting
maturation
dendritic
cells
(DCs),
T
cell
infiltration,
differentiation
natural
killer
(NK)
memory
cells,
thereby
activating
strong
immune
response.
Consequently,
it
significantly
inhibited
both
primary
distant
tumors,
while
also
limiting
lung
summary,
study
proposed
configuration-mediated
transition
strategy
efficient
immunotherapy,
advancing
frontiers
organic
agents
(OPTAs)
design
synthesis.
Abstract
Exploiting
single
molecular
species
synchronously
affording
powerful
second
near‐infrared
(NIR‐II)
fluorescence,
superior
photoacoustic
output,
prominent
reactive
oxygen
generation,
and
satisfactory
photothermal
conversion
is
supremely
appealing
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
electron
donor/π‐bridge
engineering
implemented
on
the
basis
of
6,7‐di(thiophen‐2‐yl)‐[1,2,5]thiadiazolo[3,4‐
g
]quinoxaline
moiety.
The
optimal
molecule,
namely
TPATO‐TTQ,
demonstrates
to
exhibit
those
notable
features
requested
by
exceptional
which
are
systematically
elucidated
through
depictions
excited‐state
energy
dissipation
pathways
influence
intramolecular
motion
photophysical
properties,
with
assistances
quantum
chemical
calculation
dynamic
simulation.
By
utilizing
TPATO‐TTQ
nanoparticles,
unprecedented
performance
NIR‐II
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐navigated
type
I
photodynamic‐photothermal
synergistic
therapy
orthotopic
breast
cancer
authenticates
precise
tumor
diagnosis
complete
ablation.
