Two‐Photon Mediated Cancer Therapy: A Comprehensive Review on Two‐Photon Photodynamic Therapy and Two‐Photon‐Activated Therapeutic Delivery Systems
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(48)
Опубликована: Июль 18, 2024
Abstract
Two‐photon
excitation
(2PE)
represents
substantial
advantages
in
biophotonics
over
traditional
one‐photon
(1PE),
offering
enhanced
spatial
resolution
and
deeper
tissue
penetration
capabilities.
Since
its
introduction
the
1990s,
two‐photon
excited
microscopy
has
spurred
rapid
emergence
of
novel
2PE‐based
applications,
including
photodynamic
therapy
(PDT)
targeted
release
biologically
active
agents.
This
review
first
elucidates
fundamental
principles
2PE
before
comprehensively
examining
evolution
photosensitizers
(PSs)
for
PDT
(2P‐PDT),
covering
both
nanomaterials
small
molecules,
categorized
based
on
their
respective
characteristics.
Additionally,
it
explores
advancements
PS
development
integrating
2P‐PDT
with
other
therapeutic
modalities
(e.g.,
photothermal
therapy,
chemotherapy,
immunotherapy,
gene
etc.).
Subsequent
sections
provide
an
overview
photoactivatable
compounds
absorption
properties
controlled
various
agents
drugs,
genes,
gasotransmitters),
emphasizing
potential
anticancer
applications.
Last,
a
deep
discussion
deciphers
prospects
challenges
2P‐mediated
cancer
treatment,
particularly
concerning
clinical
translation.
Язык: Английский
Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemoresistant Cancer
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
A
series
of
dinuclear
Ir(III)
complexes
have
been
constructed
for
enhanced
photodynamic
and
photothermal
therapy
(PDT
PTT)
cisplatin-resistant
non-small-cell
lung
cancer.
They
enter
cells
via
caveolar
endocytosis,
target
mitochondria
but
not
nuclear,
generate
both
singlet
oxygen
superoxide
anion,
release
heat
when
exposed
to
infrared
(IR)
irradiation,
thus
inducing
reactive
species
(ROS)-associated
cell
disruption
thermal
ablation.
The
IR-generated
ROS
can
further
activate
caspases,
triggering
apoptosis.
Additionally,
the
deplete
intracellular
glutathione,
lead
lipid
peroxidation,
induce
ferroptosis.
selected
complex
Язык: Английский
Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics
Small Methods,
Год журнала:
2024,
Номер
8(11)
Опубликована: Сен. 25, 2024
Abstract
Despite
the
advent
of
various
medical
interventions
for
cancer
treatment,
disease
continues
to
pose
a
formidable
global
health
challenge,
necessitating
development
new
therapeutic
approaches
more
effective
treatment
outcomes.
Photodynamic
therapy
(PDT),
which
utilizes
light
activate
photosensitizer
produce
cytotoxic
reactive
oxygen
species
(ROS)
eradicating
cells,
has
emerged
as
promising
approach
due
its
high
spatiotemporal
precision
and
minimal
invasiveness.
However,
widespread
clinical
use
PDT
faces
several
challenges,
including
inefficient
production
ROS
in
hypoxic
tumor
microenvironment,
limited
penetration
depth
biological
tissues,
inadequate
accumulation
photosensitizers
at
site.
Over
past
decade,
there
been
increasing
interest
utilization
photofunctional
transition
metal
complexes
applications
their
intriguing
photophysical
photochemical
properties.
This
review
provides
an
overview
current
design
strategies
used
innovative
phototherapeutics,
aiming
address
limitations
associated
with
achieve
The
challenges
future
perspectives
on
translation
are
also
discussed.
Язык: Английский
An optical coherence tomography study of a photoactive Pt(iv) prodrug in oesophageal tissue
RSC Advances,
Год журнала:
2025,
Номер
15(5), С. 3168 - 3171
Опубликована: Янв. 1, 2025
Reflected
laser-light
images
show
that
this
photoactive
Pt(
iv
)
complex
penetrates
oesophageal
tissue
and
causes
morphological
damage
only
when
irradiated.
Язык: Английский
Unlocking the potential of iridium-osmium carbolong conjugates: a high-performance photocatalyst for melanoma therapy
Science China Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Язык: Английский
Melittin-loaded gold nanocages camouflaged by anti-MUC18 functionalized lipid bilayers for chemo-photothermal ablation of melanoma cells
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
98, С. 105868 - 105868
Опубликована: Июнь 12, 2024
Язык: Английский
Antitumor Cream: Transdermal Hydrogel Containing Liposome‐Encapsulated Ruthenium Complex for Infrared‐Controlled Multimodal Synergistic Therapy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Abstract
A
transdermal
drug
delivery
cream,
which
is
non‐invasive
and
painless,
containing
a
liposome‐encapsulated
Ru(II)
complex
(
LipoRu
)
created
for
the
treatment
of
skin
cancer.
This
formulation
capitalizes
on
synergistic
antitumor
effects
two‐photon
excited
photodynamic
therapy
(PDT),
photothermal
(PTT),
chemotherapy.
exhibits
effective
tumor
accumulation,
efficient
cellular
uptake,
pH‐sensitive
infrared‐accelerated
release,
dual
localization
to
nucleus
mitochondria.
The
released
complexes
within
cells
exert
multiple
mechanisms,
such
as
DNA
topoisomerase
RNA
polymerase
inhibition,
Type
I
II
PDT,
PTT,
photodamage,
apoptosis
ferroptosis
induction.
biodistribution
therapeutic
efficacy
in
vivo
are
systematically
compared
via
three
distinct
administration
routes:
intratumoral
injection,
intravenous
through
topical
cream
application.
positive
fabricated
here
subcutaneous
tumor‐bearing
mice
offer
optimistic
potential
painless
both
early‐stage
advanced
cancers,
well
superficially
located
solid
tumors.
Язык: Английский
From Intercalation to External Binding: Ru(II) Complexes with a Spiro Ligand for TAR RNA Selective Binding and HIV-1 Reverse Transcriptase Inhibition
Inorganic Chemistry,
Год журнала:
2024,
Номер
63(26), С. 12342 - 12349
Опубликована: Июнь 21, 2024
As
a
typical
RNA
virus,
the
genetic
information
on
HIV-1
is
entirely
stored
in
RNA.
The
reverse
transcription
activity
of
transcriptase
(RT)
plays
crucial
role
replication
and
transmission
virus.
Non-nucleoside
RT
inhibitors
(NNRTIs)
block
function
by
binding
to
site
RT,
with
very
few
targeting
viral
In
this
study,
transforming
planar
conjugated
ligands
into
spiro
structure,
we
convert
classical
Ru(II)
DNA
intercalators
nonintercalator.
This
enables
selective
transactivation
response
(TAR)
outer
side
nucleic
acids
through
dual
interactions
involving
hydrogen
bonds
electrostatic
attraction,
effectively
inhibiting
serving
as
fluorescence
probe
for
TAR
Язык: Английский
Substituent‐Modulated Excited Triplet States and Activities of Ruthenium Complexes for Dual Photodynamic/Sonodynamic Therapy to Cisplatin‐Resistant Non‐Small Cell Lung Cancer
ChemBioChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Six
polypyridyl
Ru(II)
complexes
were
designed
for
single-molecule
photodynamic
and
sonodynamic
therapy
(PDT/SDT)
synergistic
multimodal
anticancer
toward
cisplatin-resistant
NSCLC.
They
demonstrated
lowest
3ES
with
distinct
intraligand
transition
nature,
which
is
beneficial
singlet
oxygen
generation.
Remarkable
quantum
yields
of
both
superoxide
anion
under
either
808
nm
laser
irradiation
or
ultrasonic
treatment
could
induce
apoptosis
ferroptosis
A549R
cells.
Cytotoxicity
experiments
clearly
a
effect
between
PDT
SDT.
The
relationship
the
structures
these
their
cellular
biological
mechanisms
has
been
explored
in
detail.
Using
sensitizer
to
achieve
PDT/SDT
may
provide
valuable
insights
drug-resistant
tumors
that
located
deeply
hypoxic
microenvironment.
Язык: Английский
Thienothiophene‐Benzopyran Derivative and AQ4N‐Assembled Liposomes for Near‐Infrared II Fluorescence Imaging‐Guided Phototherapy, Chemotherapy, and Immune Activation
Yuanyu Tang,
Tangna Pan,
E Pang
и другие.
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Abstract
Phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
attracted
wide
attention
in
tumor
treatment.
However,
the
hypoxic
microenvironment
heat
shock
proteins
produced
by
cells
significantly
reduce
their
efficacy.
Developing
effective
phototherapy
agents
that
have
high
reactive
oxygen
species
generation
efficiency
conversion
(PCE)
while
simultaneously
utilizing
is
of
great
importance.
Here,
a
thienothiophene‐benzopyran
derivative,
BTPIC4F‐C10
designed
synthesized,
with
near‐infrared
(NIR)
absorption
fluorescence.
Then
lipid
nanoparticles
(LipBFCA
NPs)
which
encapsulated
phospholipid
bilayer
together
hypoxia‐activated
prodrug
banoxanthrone
(AQ4N)
are
constructed
for
NIR‐II
fluorescence
imaging‐guided
synergistic
PDT/PTT/chemotherapy
immune
activation.
Under
808
nm
laser
irradiation,
LipBFCA
NPs
singlet
quantum
yield
20.2%
PCE
78.8%.
With
ultra‐high
photon
energy
utilization
99%,
an
excellent
effect.
The
environment
caused
can
further
activate
AQ4N
to
transform
into
chemically
toxic
AQ4
radicals
kill
cells.
Moreover,
induce
immunogenic
cell
death,
release
tumor‐associated
antigens,
responses.
This
work
provides
new
way
clinical
application
imaging
guiding
diagnosis
Язык: Английский