Organocatalytic enantioselective construction of Si-stereocenters: recent advances and perspectives

Chemical Society Reviews, Год журнала: 2024, Номер 53(17), С. 8546 - 8562

Опубликована: Янв. 1, 2024

Silicon-stereogenic chiral organosilanes have found increasing applications in synthetic chemistry, medicinal and materials science. In this context, various asymmetric catalytic methods been established for the diverse synthesis of silicon-stereogenic silanes. particular, organocatalysis is emerging as an important complementary tool enantioselective construction silicon-stereocenters, along with rapid development chiral-metal catalyzed protocols. Its advent provides a powerful platform to achieve functionalized structural diversity, should lead great organosilicon chemistry. Tutorial Review, we highlight these latest achievements from two aspects: desymmetrizations prochiral tetraorganosilanes dynamic kinetic transformations racemic by employing five organocatalytic activation modes. The advantages, limitations value each protocol, well opportunities still open further exploration, are also discussed.

Язык: Английский

---

Advances in Palladium-Catalyzed C(sp³)–H Functionalization: The Role of Traceless Directing Groups

ACS Catalysis, Год журнала: 2024, Номер unknown, С. 15356 - 15373

Опубликована: Окт. 3, 2024

Язык: Английский

---

Enantioselective construction of silicon-stereogenic vinylsilanes from simple alkenes

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 18, 2025

The diverse utility of acyclic vinylsilanes has driven the interest in synthesis enantioenriched bearing a Si-stereogenic center. However, predominant approaches for catalytic asymmetric generation have mainly relied on transition metal-catalyzed reactions alkynes with different silicon sources. Here we successfully realize enantioselective linear silicon-stereogenic good yields and enantiomeric ratios from simple alkenes under rhodium catalysis. significance this transformation lies its ability to achieve regioconvergent enantioconvergent conversion, efficiently transforming petroleum-derived isomeric mixtures olefin feedstocks into single regio- stereoisomer product. practicality method is further exemplified by downstream transformations these leveraging functionality leaving group nature aryl substituent as well development chiral π-conjugated double bond systems.

Язык: Английский

---

Construction of axial and point chirality through Ni-catalyzed sila-cycloaddition reaction via desymmetrization and (dynamic) kinetic resolution

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Язык: Английский

---

Construction of Silicon-Stereogenic Center through Desymmetric 1,5-Palladium Migration/C—H Functionalization

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(8), С. 2608 - 2608

Опубликована: Янв. 1, 2024

Язык: Английский

---