Oxa-π, σ-Methane Rearrangement Approach for Epoxide Synthesis

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

Epoxides are significant chemicals that utilized across various fields. Here, we describe an unprecedented photochemical rearrangement approach for synthesizing a diverse collection of epoxides enabled by energy transfer catalysis under visible light conditions. The process enables the easy preparation α-amino-substituted epoxide derivatives with broad substrate scope, functional group tolerance, and mild reaction Furthermore, this photorearrangement has also been applied in complex architectures, could be easily transferred to amino alcohol derivatives. Overall, oxa-π, σ-methane provides complementary strategy existing methods through catalysis.

Язык: Английский

Facile Construction of Quaternary Carbon Centers via Dinuclear Titanium(III)‐Catalyzed Reductive Coupling of Tertiary Chlorides and Activated Olefins

ChemCatChem, Год журнала: 2024, Номер 16(20)

Опубликована: Июнь 19, 2024

Abstract The establishment of all‐carbon quaternary carbon centers represents a pivotal aspect in the synthesis numerous natural products and pharmaceutical compounds, underscoring its paramount significance synthetic organic chemistry. Herein, we present novel strategy for generation through reductive coupling tertiary halides, catalyzed by dinuclear (salen)titanium catalysts. This catalytic framework demonstrates notable reactivity towards chlorides while maintaining inertness secondary primary chlorides, thereby facilitating exceptional chemoselectivity C−C bond formation. reaction proceeds with remarkable efficiency across diverse range substrates under mild conditions.

Язык: Английский

Development of Organocatalytic Darzens Reactions Exploiting the Cyclopropenimine Superbase

Molecules, Год журнала: 2024, Номер 29(18), С. 4350 - 4350

Опубликована: Сен. 13, 2024

A truly organocatalytic approach to the Darzens reaction affording

Язык: Английский