An Ultrasound‐Activated Supramolecular Modulator Enhancing Autophagy to Prevent Ventricular Arrythmias Post‐Myocardial Infarction DOI

Yida Pang,

Qian Li,

Jiale Wang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Abstract Ventricular arrhythmias (VAs) triggered by myocardial infarction (MI) are the leading cause of sudden cardiac mortality worldwide. Current therapeutic strategies for managing MI‐induced VAs, such as left stellate ganglion resection and ablation, suboptimal, highlighting need to explore safer more effective intervention strategies. Herein, we rationally designed two supramolecular sonosensitizers RuA RuB , engineered through acceptor modification generate moderate reactive oxygen species (ROS) modulate VAs. Both demonstrated high ultrasound (US)‐activated ROS production efficiency, with singlet ( 1 O 2 ) quantum yield (Φ Δ 0.70 0.88, respectively, surpassing ligand IR1105 conventional sonosensitizer ICG =0.40). In vitro, at a modest concentration under US intensity notably boosts pro‐survival autophagy in microglia BV2 cell. To improve vivo stability biocompatibility, was further encapsulated into DSPE‐PEG 5000 prepare nanoparticles NPs). studies after microinjection NPs paraventricular nucleus (PVN) subsequent exposure, that NPs‐mediated modulation effectively suppresses sympathetic nervous activity (SNA) inflammatory responses, thereby preventing Importantly, no tissue injury observed post modulation. This work pioneers design long‐wave emission sonosensitizers, offering new insights regulating cardiovascular diseases.

Язык: Английский

A novel surface-enhanced Raman based molecular identification platform for multiplexed and highly accurate clinical diagnosis of viral diseases DOI

Yida Pang,

Qihang Ding, Lin Xu

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(31), С. 7461 - 7462

Опубликована: Янв. 1, 2024

Schematic illustration of the E-NoM platform. The workflow for simultaneous detection four viral antigens during infection process.

Язык: Английский

Процитировано

0
An Ultrasound‐Activated Supramolecular Modulator Enhancing Autophagy to Prevent Ventricular Arrythmias Post‐Myocardial Infarction DOI

Yida Pang,

Qian Li,

Jiale Wang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Abstract Ventricular arrhythmias (VAs) triggered by myocardial infarction (MI) are the leading cause of sudden cardiac mortality worldwide. Current therapeutic strategies for managing MI‐induced VAs, such as left stellate ganglion resection and ablation, suboptimal, highlighting need to explore safer more effective intervention strategies. Herein, we rationally designed two supramolecular sonosensitizers RuA RuB , engineered through acceptor modification generate moderate reactive oxygen species (ROS) modulate VAs. Both demonstrated high ultrasound (US)‐activated ROS production efficiency, with singlet ( 1 O 2 ) quantum yield (Φ Δ 0.70 0.88, respectively, surpassing ligand IR1105 conventional sonosensitizer ICG =0.40). In vitro, at a modest concentration under US intensity notably boosts pro‐survival autophagy in microglia BV2 cell. To improve vivo stability biocompatibility, was further encapsulated into DSPE‐PEG 5000 prepare nanoparticles NPs). studies after microinjection NPs paraventricular nucleus (PVN) subsequent exposure, that NPs‐mediated modulation effectively suppresses sympathetic nervous activity (SNA) inflammatory responses, thereby preventing Importantly, no tissue injury observed post modulation. This work pioneers design long‐wave emission sonosensitizers, offering new insights regulating cardiovascular diseases.

Язык: Английский

Процитировано

0