Stacking machine learning models for predicting photophysical properties of iridium complexes
Journal of Photochemistry and Photobiology A Chemistry,
Год журнала:
2025,
Номер
unknown, С. 116374 - 116374
Опубликована: Март 1, 2025
Язык: Английский
Gallium‐Magnesium Layered Double Hydroxide for Elevated Tumor Immunotherapy Through Multi‐Network Synergistic Regulation
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Abstract
Immunotherapeutic
efficacy
is
often
limited
by
poor
immunogenicity,
immunosuppressive
tumor
microenvironment
(TME),
and
cytoprotective
mechanisms,
leading
to
low
immune
activation.
To
this
end,
here,
L‐amino
acid
oxidase
(LAAO)
loaded
gallium‐magnesium
layered
double
hydroxide
(MG‐LAAO)
prepared
for
significantly
enhanced
immunotherapy
through
multi‐network
synergistic
regulation.
First,
MG‐LAAO
induces
cell
pyroptosis
initiating
caspase‐1/GSDMD
caspase‐3/GSDME
pathways,
further
triggering
immunogenic
death
(ICD).
Then
the
released
Ga
3+
mitochondrial
iron
overload,
resulting
in
ferroptosis.
In
addition,
also
hinders
autophagy
of
cells,
reshapes
(TME)
neutralizing
H
+
inhibiting
lactic
accumulation,
thus
destroying
mechanism
avoiding
escape.
Furthermore,
synergy
activates
cGAS‐STING
signaling
pathway,
generating
powerful
antitumor
immunotherapy.
This
work
highlights
critical
role
synergies
between
block,
pyroptosis,
ferroptosis,
ICD
immunotherapy,
demonstrating
important
effectively
overcoming
TME
enhancing
immunogenicity.
particular,
gallium‐induced
revealed
first
time,
providing
theoretical
support
design
new
materials
future.
Язык: Английский
Designing novel tridentate iridium(III) complexes comprising functionalized benzothiazole ligands to improve anticancer activity by targeting mitochondria
Bioorganic Chemistry,
Год журнала:
2025,
Номер
unknown, С. 108507 - 108507
Опубликована: Апрель 1, 2025
Язык: Английский
Molecular engineering strategies for fabricating type-I mitochondria-targeted aggregation-induced emission photosensitizers for apoptosis-ferroptosis synergistically boosting photodynamic therapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
694, С. 137680 - 137680
Опубликована: Апрель 23, 2025
Язык: Английский
Pyrazolo[1,5-a]pyrimidine-Based Type-I Photosensitizer as an Efficient Pyroptosis Inducer for Tumor Ablation
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 4, 2025
Pyroptosis
is
a
proinflammatory
and
lytic
programmed
cell
death
form,
which
can
promote
cytotoxic
T
lymphocyte
(CTL)
maturation
tumor
infiltration
through
the
release
of
damage-associated
molecular
patterns
(DAMPs).
Therefore,
induction
pyroptosis
by
small
molecules
promising
strategy
to
activate
antitumor
immunity.
In
this
work,
we
report
design
new
class
pyrazolo[1,5-a]pyrimidine-based
type-I
photosensitizers
(PSs)
as
efficient
inducers
for
cancer
photodynamic
therapy
(PDT).
Among
compounds,
ZS-3
exhibited
most
excellent
reactive
oxygen
species
(ROS)
generation
ability
phototoxicity
in
vitro.
It
was
found
that
induced
caspase-3/gasdermin
E
(GSDME)
pathway
under
light
irradiation,
characterized
bubble
formation
pattern
release.
Furthermore,
lipid
nanoparticles
significantly
inhibited
growth
evoked
immune
responses
vivo.
Язык: Английский
Advances in cancer immunotherapy: historical perspectives, current developments, and future directions
Mei‐Yin Zhang,
Chao-jun Liu,
Jing Tu
и другие.
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Май 7, 2025
Cancer
immunotherapy,
encompassing
both
experimental
and
standard-of-care
therapies,
has
emerged
as
a
promising
approach
to
harnessing
the
immune
system
for
tumor
suppression.
Experimental
strategies,
including
novel
immunotherapies
preclinical
models,
are
actively
being
explored,
while
established
treatments,
such
checkpoint
inhibitors
(ICIs),
widely
implemented
in
clinical
settings.
This
comprehensive
review
examines
historical
evolution,
underlying
mechanisms,
diverse
strategies
of
cancer
highlighting
its
applications
ongoing
advancements.
The
delves
into
essential
components
anticancer
immunity,
dendritic
cell
activation,
T
priming,
surveillance,
addressing
challenges
posed
by
evasion
mechanisms.
Key
immunotherapeutic
vaccines,
oncolytic
viruses,
adoptive
transfer,
ICIs,
discussed
detail.
Additionally,
role
nanotechnology,
cytokines,
chemokines,
adjuvants
enhancing
precision
efficacy
were
explored.
Combination
particularly
those
integrating
immunotherapy
with
radiotherapy
or
chemotherapy,
exhibit
synergistic
potential
but
necessitate
careful
management
reduce
side
effects.
Emerging
factors
influencing
outcomes,
heterogeneity,
gut
microbiota
composition,
genomic
epigenetic
modifications,
also
examined.
Furthermore,
molecular
mechanisms
therapeutic
resistance
analyzed,
focus
on
contributions
noncoding
RNAs
alterations,
along
innovative
intervention
strategies.
emphasizes
recent
advancements,
particular
attention
biomarker-driven
approaches
aimed
at
optimizing
patient
prognosis.
Challenges
immunotherapy-related
toxicity,
limited
solid
tumors,
production
constraints
highlighted
critical
areas
future
research.
Advancements
personalized
therapies
delivery
systems
proposed
avenues
enhance
treatment
effectiveness
accessibility.
By
incorporating
insights
from
multiple
disciplines,
this
aims
deepen
understanding
application
ultimately
fostering
more
effective
accessible
solutions.
Язык: Английский
Microwave‐Responsive AlEu‐MOFs Potentiate NLRP3‐Mediated Pyroptosis via a “Triple Initiating” Tactic for Breast Cancer Microwave‐Immunotherapy
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Abstract
Microwave
thermotherapy
is
favored
in
clinical
practice
for
breast
cancer
conservation
strategies
due
to
its
minimally
invasive
characteristic.
Nevertheless,
the
immunosuppressive
tumor
microenvironment
(TME)
significantly
attenuates
therapeutic
efficacy
of
anti‐tumor
immune
response,
posing
challenges
effectively
preventing
recurrence
and
metastasis.
Pyroptosis,
a
recently
identified
form
programmed
cell
death
triggered
by
inflammasomes,
presents
unique
inflammatory
immunogenic
properties
that
hold
promise
immunotherapy.
Herein,
microwave‐responsive
AlEu‐MOFs
are
designed
synthesized
boost
NLRP3‐mediated
pyroptosis
via
“Triple
Initiating”
tactic
microwave‐immunotherapy.
The
potent
microwave
thermal
effect
AEM
facilitates
up‐regulation
HSP90,
thereby
initiating
NLRP3
expression.
Concurrently,
it
induces
mitochondrial
dysfunction
generate
substantial
quantities
ROS,
further
enhancing
expression
achieve
targeted
amplification
thermotherapy‐induced
pyroptosis.
Simultaneously,
directed
anchoring
release
highly
active
metal
ions
promotes
activation
inflammasome
jointly,
ultimately
inducing
high‐efficiency
This
innovative
“2M”
(materials
methods)
dual‐pronged
strategy
not
only
inhibits
primary
proliferation,
but
also
impedes
distant
progression
lung
work
provides
novel
accurately
offers
new
approach
overcome
obstacles
thermotherapy.
Язык: Английский
Synergistic photoinduction of ferroptosis and apoptosis by a mitochondria-targeted iridium complex for bladder cancer therapy
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
683, С. 420 - 431
Опубликована: Дек. 12, 2024
Bladder
cancer
(BC)
is
one
of
the
most
common
malignant
tumors
urinary
system,
and
has
a
high
recurrence
rate
treatment
resistance.
Recent
results
indicate
that
mitochondrial
metabolism
influences
therapeutic
outcomes
BC.
Mitochondria-targeted
photosensitizer
(PS)
promising
anticancer
approach
may
overcome
limitations
conventional
BC
treatments.
Herein,
two
mitochondria-targeted
iridium(III)
PSs,
Ir-Mito1
Ir-Mito2,
have
been
designed
for
treatment.
Mechanically,
Ir-Mito2
induced
decrease
in
membrane
potential
via
white
light
activation,
further
triggering
reduction
B-cell
lymphoma
2
protein
(Bcl-2)/Bcl-associated
X
(Bax)
ratio
increment
cleaved
caspase3.
Meanwhile,
glutathione,
deactivation
glutathione
peroxidase
4
(GPX4),
increase
acyl-CoA
synthetase
long
chain
family
member
(ACSL4),
accumulation
lipid
peroxide
resulted
synergistically
activating
ferroptosis
apoptosis.
The
demonstrated
exhibited
excellent
antitumor
efficacy
with
superior
biosafety
vivo.
This
work
on
light-activated
mitochondrial-targeted
PS
provides
an
innovative
platform
Язык: Английский