Synthesis and Application of Selenium Nanoparticles for the Modulation of Inflammatory Diseases

Nano Biomedicine and Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Boosting Peroxidase-Mimetic Activity of FeMn-NC_e Dual-Atom Radiosensitizing Nanozymes for Augmented Radiodynamic Immunotherapy

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.

Язык: Английский

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Maintaining cardiac homeostasis by translational selenium nanoparticles with rapid selenoproteins regulation to achieve radiation-induced heart prevention

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160005 - 160005

Опубликована: Янв. 1, 2025

Язык: Английский

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Mn-Specific Recognition of Guanidine Drives Selective Inhibition of Complex I

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Developing structurally well-defined targeted drugs is an effective way to enhance the chemotherapy efficacy. Herein, a target mitochondrial complex I (complex I) inhibitor was developed for key methylation site ARG-85 in subunit NDUFS2. Based on unique :NH═C- group of guanidyl and surrounding environment ARG-85, macrocyclic bulky manganese porphyrin [MnIII(TTPPC2-)]+ selected insert into gap Experimental computational analyses revealed that planar π system TTPPC2- ligand rotatable benzene ring stably bind between metal center, medium-strong Lewis acid. The Mn-specific recognition guanidine drives selective inhibition activity. Further, MnIII(TTPPC2-)]+ modified nanoformulation Mn NPs. In vitro vivo experiments confirmed efficient mechanism activity, offering novel strategy drug development.

Язык: Английский

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Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective personalized cancer treatments. However, requirement doses X-ray irradiation to break chemical bonds for limits application prodrug activation clinics. Recent advances nanomaterials offer a promising approach radiotherapy sensitization well integrating multiple modalities improved therapy outcomes. In particular, catalytic radiosensitization that utilizes electrons energy generated by upon has demonstrated excellent potential enhanced radiotherapy. this Review, we summarize design principles X-ray-responsive controlled release, radiosensitization, recent progress nanoradiosensitizers integration chemotherapy, chemodynamic therapy, photodynamic photothermal gas immunotherapy. Finally, discuss challenges heading toward possible translation. We expect emerging based on radiotherapy-triggered will facilitate frontier accurate near future.

Язык: Английский

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Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 20, 2025

Sepsis-induced acute lung injury (ALI) remains a critical clinical challenge with complex inflammatory pathogenesis. While bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential through anti-inflammatory and cytoprotective effects, their age-related functional decline limits utility. This study developed chitosan-functionalized selenium nanoparticles (SeNPs@CS, 100 nm) to rejuvenate BMSCs miR-20b-mediated selenoprotein biosynthesis. Mechanistic investigations revealed that SeNPs@CS-treated exhibited enhanced mitochondrial transfer capacity, delivering mitochondria damaged alveolar epithelial (AECII) for cellular repair. Concurrently, miR-20b upregulation suppressed the RORγt/STAT3/Th17 axis, reducing pro-inflammatory Th17 cell differentiation in CD4+ T lymphocytes. The dual-target mechanism integrates immunomodulation via pathway inhibition rejuvenation therapy, representing paradigm-shifting approach ALI management. These engineered mitigated markers murine models, demonstrating superior efficacy conventional BMSC therapies. Our findings establish SeNPs@CS-modified as novel platform combining nanotechnology-enhanced engineering precision immunometabolic regulation, providing new avenues treatment of sepsis-induced ALI.

Язык: Английский

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Translational selenium nanoparticles enhance NKG2D-mediated cytotoxicity of NK cells against malignant pleural mesothelioma cells through the TrxR1-pSTAT3 pathway

Nano Today, Год журнала: 2025, Номер 62, С. 102720 - 102720

Опубликована: Март 28, 2025

Язык: Английский

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Light-Responsive Ru–Se Coordinated Nanoreactor Spatiotemporally Relieves Hypoxia for Photodynamic Therapy of Bladder Cancer

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Photodynamic therapy (PDT) has been employed as a noninvasive treatment option for bladder cancer due to its controllability and minimal toxicity. However, the efficacy of PDT is often compromised by hypoxic microenvironment solid tumors. To address this challenge, our research dedicated developing Ru-Se-Ce6 nanoreactor that combines photoresponsiveness Ru-Se coordination bonds reactive oxygen species (ROS) triggered diselenide bonds, achieving dual-controlled release photosensitizer enhance effectiveness. The photoresponsive catalytic characteristics were validated through synchrotron radiation density functional theory calculations. Under laser irradiation, metal-to-ligand charge transfer (MLCT) within ruthenium complex leads cleavage bond, resulting in liberation complex, which significantly improves O2 generation from H2O2 tumor (TME). In vivo assessments demonstrated disrupted mitochondrial membrane potential via excessive ROS production, leading cell cycle arrest apoptosis. Additionally, revealed significant suppression subcutaneous orthotopic models while exhibiting good biocompatibility. These findings propose potent innovative approach therapy.

Язык: Английский

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Traditional Chinese medicine-facilitated redox-labile paclitaxel dimer nanoprodrug for efficient chemoimmunotherapy

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101348 - 101348

Опубликована: Май 1, 2025

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