Enantioselective Desymmetrization of Phosphinic Acids via Cu-Catalyzed O-Arylation
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 4719 - 4725
Опубликована: Март 6, 2025
Язык: Английский
Copper-Catalyzed Dynamic Kinetic Asymmetric Arylation of Secondary Phosphine-Boranes for the Synthesis of P(III)-Stereogenic Centers
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 14, 2025
Transition-metal-catalyzed
asymmetric
C-P(III)
bond
formation
is
a
direct
method
for
the
construction
of
P(III)-stereogenic
centers;
however,
achieving
high
enantioselectivity
remains
challenge.
Herein,
an
unprecedented
Cu-catalyzed
dynamic
kinetic
resolution
secondary
phosphine-boranes
was
successfully
developed.
This
C-P(BH3)
coupling
reaction
provided
and
highly
enantioselective
synthesis
centers,
enabling
chiral
medium-sized
benzophosphine-boranes
(7-10-membered
cycles).
A
mechanism
involving
unusual
rapid
racemization
has
been
proposed.
Язык: Английский
Integrating Achiral Brønsted Base and Chiral Bisguanidinium for Enantioselective Phospha-Michael Addition to Chalcones
Zhenghao Wan,
Hongjie Cao,
Chao Wang
и другие.
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 6426 - 6433
Опубликована: Апрель 4, 2025
Язык: Английский
Nickel-Catalyzed Asymmetric Synthesis of Ambiphilic Secondary Phosphine Oxides
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
The
synthesis
of
ambiphilic
compounds,
which
possess
both
strong
nucleophilic
and
electrophilic
functional
groups,
presents
a
significant
challenge
due
to
their
propensity
self-react,
forming
oligomers
or
polymers.
We
have
successfully
achieved
the
nickel-catalyzed
asymmetric
P-stereogenic
alkenyl
secondary
phosphine
oxides
from
tailored
primary
oxide
by
leveraging
controversial
stability
reactivity.
This
method
demonstrates
remarkable
tolerance
toward
wide
range
unactivated
alkynes,
including
those
derived
natural
products
medicinally
relevant
molecules,
thus
providing
universal
synthon
for
phosphines
with
high
enantioselectivity
regioselectivity.
product
exhibits
interesting
orthogonal
reactivities
nucleophiles
electrophiles
can
be
easily
converted
variety
compounds.
Язык: Английский
Dynamic Kinetic Asymmetric P–C Coupling of Secondary Phosphine Oxides with Alkenyl Iodides
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 2, 2025
Transition
metal-catalyzed
enantioselective
P-C
bond-forming
reactions
between
racemic
secondary
phosphine
oxides
(SPOs)
and
various
electrophiles
have
emerged
as
powerful
strategies
for
accessing
P-chiral
compounds.
However,
most
reported
transformations
proceeded
via
kinetic
resolution
of
SPOs,
inherently
limiting
efficiency.
In
contrast,
dynamic
asymmetric
coupling
enables
full
conversion
SPOs─offering
a
more
effective
pathway─yet
such
methods
remain
rare.
Herein,
we
report
the
first
SPOs
with
alkenyl
iodides.
This
transformation,
enabled
by
copper
catalyst
bearing
novel
chiral
1,2-diamine
ligand,
affords
broad
range
tertiary
in
good
yields
high
enantioselectivity.
Язык: Английский
Recent Advances in Transition Metal‐Catalyzed Asymmetric Synthesis of P‐chiral Organophosphorus Compounds (2020–Present)
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
Comprehensive
Summary
P
‐chiral
organophosphorus
compounds
have
demonstrated
unparalleled
application
potential
in
diverse
fields,
including
medicine,
agricultural
science,
material
and
life
science.
Furthermore,
they
serve
as
highly
effective
chiral
ligands
both
transition
metal‐catalyzed
organocatalytic
asymmetric
transformations.
In
recent
years,
significant
advances
been
made
the
catalytic
synthesis
of
compounds,
with
phosphination
hydrophosphination
reactions
emerging
dominant
strategies.
This
review
systematically
summarizes
methodological
developments
from
2020
to
present
for
constructing
compounds.
The
discussion
is
organized
according
different
metals,
aiming
provide
a
valuable
reference
inspiration
researchers
organic
chemistry.
Key
Scientists
Язык: Английский