Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction DOI Creative Commons

Xin Zhang,

Shuai Shao,

Qiuting Li

и другие.

Reviews in Cardiovascular Medicine, Год журнала: 2025, Номер 26(3)

Опубликована: Март 24, 2025

This review examines the mechanisms of left ventricular dysfunction, focusing on interplay between remodeling, autophagy, and mitochondrial dysfunction following myocardial infarction. Left directly affects heart's pumping efficiency can lead to severe clinical outcomes, including heart failure. After infarction, ventricle may suffer from weakened contractility, diastolic cardiac progressing Thus, this article discusses pathophysiological processes involved in injury repair infarcted non-infarcted myocardia, adaptive changes, specific changes systolic functions. Furthermore, role autophagy maintaining cellular energy homeostasis, clearing dysfunctional mitochondria, key failure is addressed. Finally, therapeutic strategies targeting enhancing mitophagy, providing clinicians researchers with latest insights future research directions.

Язык: Английский

A Review on Perception of Binding Kinetics in Affinity Biosensors: Challenges and Opportunities DOI Creative Commons
Brandy Renee McCann,

Brandon Daniel Tipper,

Sepeedeh Shahbeigi

и другие.

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

There are challenges associated with design and development of affinity biosensors due to the complicated multiphysics nature system. Understanding binding interaction between target molecules immobilized receptors its kinetics is a crucial step develop robust reliable biosensor technologies. Evaluation in becomes more important challenging for clinical samples complex matrix. Despite drastic advancements technologies, having practical perception has remained critical bottleneck limited fundamental understanding. This Review aims provide comprehensive discussion on concepts advances developed so far biosensors. Here, modeling approaches measurement techniques presented characterize interactions while effect fouling secondary factors will be discussed concept kinetics. investigate existing research gaps potential opportunities

Язык: Английский

Процитировано

0
Twin-Tail Tadpole-Shaped Ce6-Peptide Conjugate for Enhanced Photodynamic Cancer Therapy DOI
Mengmeng Jiang,

Shaowen Wu,

Hongxia Zhang

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered RFYFYR-Ce6-RFYFYR (R-Ce6-R), a twin-tail peptide–photosensitizer conjugate that self-assembles into nanostructures for improved cancer treatment. By incorporating arginine-rich peptide sequences, this design not only enhances cellular internalization but also promotes peroxynitrite (ONOO–) formation, amplifying the effect. Our studies revealed R-Ce6-R achieves 33-fold higher potency than unmodified Ce6, with an IC50 of 0.18 μM. The demonstrated selective accumulation tissue, robust ROS generation, complete regression animal models while maintaining favorable safety profile. These results establish as innovative approach advancing

Язык: Английский

Процитировано

0
Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction DOI Creative Commons

Xin Zhang,

Shuai Shao,

Qiuting Li

и другие.

Reviews in Cardiovascular Medicine, Год журнала: 2025, Номер 26(3)

Опубликована: Март 24, 2025

This review examines the mechanisms of left ventricular dysfunction, focusing on interplay between remodeling, autophagy, and mitochondrial dysfunction following myocardial infarction. Left directly affects heart's pumping efficiency can lead to severe clinical outcomes, including heart failure. After infarction, ventricle may suffer from weakened contractility, diastolic cardiac progressing Thus, this article discusses pathophysiological processes involved in injury repair infarcted non-infarcted myocardia, adaptive changes, specific changes systolic functions. Furthermore, role autophagy maintaining cellular energy homeostasis, clearing dysfunctional mitochondria, key failure is addressed. Finally, therapeutic strategies targeting enhancing mitophagy, providing clinicians researchers with latest insights future research directions.

Язык: Английский

Процитировано

0