An aptazyme-based logic gate biosensor for tumor detection in postoperative analysis

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137594 - 137594

Опубликована: Март 1, 2025

Язык: Английский

DNA Nanostructures for Rational Regulation of Cellular Organelles

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

DNA nanotechnology has revolutionized materials science and biomedicine by enabling precise manipulation of matter at the nanoscale. nanostructures (DNs) in particular represent a promising frontier for targeted therapeutics. Engineered DNs offer unprecedented molecular programmability, biocompatibility, structural versatility, making them ideal candidates advanced drug delivery, organelle regulation, cellular function modulation. This Perspective explores emerging role modulating behavior through organelle-targeted interventions. We highlight current advances nuclear, mitochondrial, lysosomal targeting, showcasing applications ranging from gene delivery to cancer For instance, have enabled precision mitochondrial disruption cells, pH modulation enhance silencing, nuclear gene-editing templates. While hold immense promise advancing nanomedicine, outstanding challenges include optimizing biological interactions addressing safety concerns. highlights potential rational control organelles, which could lead novel therapeutic strategies advancement nanomedicines future.

Язык: Английский

Real-Time Imaging and Quantitative Exploration of Lysosomal ATP Regulatory Pathways under Oxidative Stress by a Dual-Channel Fluorescence-On Probe

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137836 - 137836

Опубликована: Апрель 1, 2025

Язык: Английский