Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications DOI Creative Commons
Siyuan Wang, Xudong Cui,

Zixuan Zhong

и другие.

Biosensors, Год журнала: 2025, Номер 15(6), С. 336 - 336

Опубликована: Май 24, 2025

Photoactivatable aptamer sensing technology is widely used in various detection fields due to its precise spatiotemporal regulation ability, flexible material compatibility, and excellent performance. By introducing an optical response mechanism regulate the efficient recognition of target by sensor, this strategy further broadens means aptamer. The application photoactivated biosensors point-of-care testing (POCT) can significantly improve selectivity, sensitivity, dynamic ability POCT system. This review systematically explores design principle photoactivatable aptamers, with a focus on reviewing progress them platform. In addition, existing challenges future development trends are also discussed. It expected that biosensor based aptamers will continue drive towards higher intelligence, scene adaptability, providing innovative tools for precision medicine environmental health monitoring.

Язык: Английский

An aptazyme-based logic gate biosensor for tumor detection in postoperative analysis DOI
Guojia Fang, Kai Wen,

Qixuan Zhao

и другие.

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137594 - 137594

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
DNA Nanostructures for Rational Regulation of Cellular Organelles DOI Creative Commons

Petra Elblová,

Judita Anthi, Minghui Liu

и другие.

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

DNA nanotechnology has revolutionized materials science and biomedicine by enabling precise manipulation of matter at the nanoscale. nanostructures (DNs) in particular represent a promising frontier for targeted therapeutics. Engineered DNs offer unprecedented molecular programmability, biocompatibility, structural versatility, making them ideal candidates advanced drug delivery, organelle regulation, cellular function modulation. This Perspective explores emerging role modulating behavior through organelle-targeted interventions. We highlight current advances nuclear, mitochondrial, lysosomal targeting, showcasing applications ranging from gene delivery to cancer For instance, have enabled precision mitochondrial disruption cells, pH modulation enhance silencing, nuclear gene-editing templates. While hold immense promise advancing nanomedicine, outstanding challenges include optimizing biological interactions addressing safety concerns. highlights potential rational control organelles, which could lead novel therapeutic strategies advancement nanomedicines future.

Язык: Английский

Процитировано

0
Real-Time Imaging and Quantitative Exploration of Lysosomal ATP Regulatory Pathways under Oxidative Stress by a Dual-Channel Fluorescence-On Probe DOI
Zhou Wu, Bin Yang, Wangbo Qu

и другие.

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137836 - 137836

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Modular Engineering of Enzyme‐Activatable DNA Nanodevices for Endoplasmic Reticulum‐Targeted Photodynamic Antitumor Therapy DOI

Dejie Lu,

Yanfei Jia, Yaoxuan Chen

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Abstract Endoplasmic reticulum (ER)‐targeted photodynamic therapy (PDT) has garnered wide attention for its potential to improve tumor treatment outcomes. However, achieving spatially selective control over the activation of photosensitizers (PSs) within ER remains a major challenge. In this study, programmable DNA nanodevice, termed EDEP, designed targeted delivery and localized PSs, thereby ER‐specific activatable therapy, is presented. This modular engineered nanodevice comprises an enzyme‐activatable, DNA‐based PS (ED), nanocarrier ER‐targeting ligand, allowing it accumulate specifically lumen. The ED features unique enzyme‐responsive turn‐on mechanism that selectively activates upon interaction with enzyme, facilitating controlled reactive oxygen species (ROS) generation at subcellular site. It demonstrated EDEP enables ROS production in ER, leading significant cytotoxicity cells. Furthermore, induces mitochondrial permeability transition pore opening, resulting dysfunction amplified cell death. work presents enzyme‐controlled, ER‐targeted PDT strategy holds promise precise cancer therapy.

Язык: Английский

Процитировано

0
Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications DOI Creative Commons
Siyuan Wang, Xudong Cui,

Zixuan Zhong

и другие.

Biosensors, Год журнала: 2025, Номер 15(6), С. 336 - 336

Опубликована: Май 24, 2025

Photoactivatable aptamer sensing technology is widely used in various detection fields due to its precise spatiotemporal regulation ability, flexible material compatibility, and excellent performance. By introducing an optical response mechanism regulate the efficient recognition of target by sensor, this strategy further broadens means aptamer. The application photoactivated biosensors point-of-care testing (POCT) can significantly improve selectivity, sensitivity, dynamic ability POCT system. This review systematically explores design principle photoactivatable aptamers, with a focus on reviewing progress them platform. In addition, existing challenges future development trends are also discussed. It expected that biosensor based aptamers will continue drive towards higher intelligence, scene adaptability, providing innovative tools for precision medicine environmental health monitoring.

Язык: Английский

Процитировано

0